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The pathogen causes bacillary dysentery, a bloody diarrheal disease characterized by damage to the colonic mucosa and is usually spread through the fecal-oral route. Small animal models of shigellosis that rely on the oral route of infection are lacking. Here, we found that orogastric inoculation of infant rabbits with\n                    <jats:named-content content-type=\"genus-species\">S. flexneri<\/jats:named-content>\n                    led to a diarrheal disease and colonic pathology reminiscent of human shigellosis. Diarrhea, intestinal colonization, and pathology in this model were dependent on the\n                    <jats:named-content content-type=\"genus-species\">S. flexneri<\/jats:named-content>\n                    type III secretion system and IcsA, canonical\n                    <jats:italic>Shigella<\/jats:italic>\n                    virulence factors. Thus, oral infection of infant rabbits offers a feasible model to study the pathogenesis of shigellosis and to develop and test new therapeutics.\n                  <\/jats:p>","DOI":"10.1128\/mbio.03105-19","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T04:38:05Z","timestamp":1579495085000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["An Oral Inoculation Infant Rabbit Model for\n                    <i>Shigella<\/i>\n                    Infection"],"prefix":"10.1128","volume":"11","author":[{"given":"Carole J.","family":"Kuehl","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Brigham &amp; Women\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"D\u2019Gama","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham &amp; Women\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson R.","family":"Warr","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham &amp; Women\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew K.","family":"Waldor","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham &amp; Women\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Howard Hughes Medical Institute, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Guidelines for the control of shigellosis, including epidemics due to Shigella dysenteriae type 1","author":"Legros D","year":"2005","unstructured":"Legros D, Pierce N. 2005. 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