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However, the role of bacterial population diversity within the context of chronic infection is still poorly understood. In this study, we found that hypermutator strains of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    in the CF lung undergoing treatment with tobramycin evolved increased sensitivity to tobramycin relative to non-hypermutators within the same population. This finding suggests that antimicrobial treatment may only exert weak selection pressure on\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    populations in the CF lung. We further found no evidence for collateral sensitivity in these clinical populations, suggesting that collateral sensitivity may not be a robust, naturally occurring phenomenon for this microbe.\n                  <\/jats:p>","DOI":"10.1128\/mbio.03109-23","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T17:48:17Z","timestamp":1704304097000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    populations in cystic fibrosis lung infection"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4520-2867","authenticated-orcid":false,"given":"Jelly","family":"Vanderwoude","sequence":"first","affiliation":[{"name":"Center for Microbial Dynamics and Infection, School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-6087","authenticated-orcid":false,"given":"Sheyda","family":"Azimi","sequence":"additional","affiliation":[{"name":"Center for Microbial Dynamics and Infection, School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA"},{"name":"Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8966-9680","authenticated-orcid":false,"given":"Timothy D.","family":"Read","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3093-0412","authenticated-orcid":false,"given":"Stephen P.","family":"Diggle","sequence":"additional","affiliation":[{"name":"Center for Microbial Dynamics and Infection, School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-0550(02)00003-3"},{"key":"e_1_3_5_3_2","unstructured":"Cystic Fibrosis Foundation. 2021. 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