{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:34:38Z","timestamp":1787016878764,"version":"build-2736575974"},"reference-count":81,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Broad Institute TB Gift Donors"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2024,2,14]]},"abstract":"<jats:p>\n                    Tuberculosis is a global threat, with ~10 million yearly active cases. Many more people, however, live with \u201clatent\u201d infection, where\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    survives in a non-replicative form. When latent bacteria activate and regrow, they elicit immune responses and result in significant host damage. Replicating and non-growing bacilli can co-exist; however, non-growing bacteria are considerably less sensitive to antibiotics, thus complicating treatment by necessitating long treatment durations. Here, we sought to identify genes important for bacterial survival in this non-growing state using a carbon starvation model. We found that a previously uncharacterized gene,\n                    <jats:italic>omamC<\/jats:italic>\n                    , is involved in storing and utilizing fatty acids as bacteria transition between these two states. Importantly, inhibiting lipid metabolism using a lipase inhibitor eradicates non-growing bacteria. Thus, targeting lipid metabolism may be a viable strategy for treating the non-growing population in strategies to shorten treatment durations of tuberculosis.\n                  <\/jats:p>","DOI":"10.1128\/mbio.03208-23","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T09:01:37Z","timestamp":1705568497000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Genetic factors affecting storage and utilization of lipids during dormancy in\n                    <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-0428","authenticated-orcid":false,"given":"Alexander","family":"Sturm","sequence":"first","affiliation":[{"name":"Infectious Disease and Microbiome Program, Broad Institute, Cambridge, Massachusetts, USA"},{"name":"Department of Molecular Biology and Center for Computational and Integrative 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