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Imprinting has been implicated in both protective effects as well as blunting of the immune response to vaccines. Despite the fact that this phenomenon was already described almost 60\u2009years ago, we have very little detailed knowledge of the characteristics and breadth of the immune response to the first exposure(s) to influenza virus in life and how this compares to later exposure as adults. Here, we investigate these immune responses in detail using an influenza virus protein microarray. While our findings are mostly descriptive in nature and based on a small sample size, they provide a strong basis for future large-scale studies to better understand imprinting effects.<\/jats:p>","DOI":"10.1128\/mbio.03243-19","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T09:38:05Z","timestamp":1579513085000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":65,"title":["Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults"],"prefix":"10.1128","volume":"11","author":[{"given":"Philip","family":"Meade","sequence":"first","affiliation":[{"name":"Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA"},{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"},{"name":"Centers of Excellence for Influenza Research and Surveillance 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Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihito","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics, Hokkaido University Research Center for Zoonosis Control, Kitaku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ericka","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA"},{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"},{"name":"Centers of Excellence for Influenza Research and Surveillance (CEIRS)"},{"name":"Center for Research on Influenza Pathogenesis (CRIP), New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Javier","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, 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Michigan, Ann Arbor, Michigan, USA"},{"name":"St. Jude Center of Excellence for Influenza Research and Surveillance, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-776X","authenticated-orcid":false,"given":"Florian","family":"Krammer","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"},{"name":"Centers of Excellence for Influenza Research and Surveillance (CEIRS)"},{"name":"Center for Research on Influenza Pathogenesis (CRIP), New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0143-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0463-x"},{"key":"e_1_3_2_4_2","first-page":"572","article-title":"On the doctrine of original antigenic 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