{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:07:45Z","timestamp":1792642065350,"version":"4.5.0"},"reference-count":65,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-19-CE44-0018"],"award-info":[{"award-number":["ANR-19-CE44-0018"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-EURE-0003"],"award-info":[{"award-number":["ANR-17-EURE-0003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010076","name":"Conseil R\u00e9gional Provence-Alpes-C\u00f4te d'Azur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM122506"],"award-info":[{"award-number":["GM122506"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1537\/18"],"award-info":[{"award-number":["1537\/18"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1765\/13"],"award-info":[{"award-number":["1765\/13"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013349","name":"LABoratoires d'EXcellence ARCANE","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2022,4,26]]},"abstract":"<jats:p>With the increase of antibiotic drug resistance, alternative antibacterial treatment strategies are needed. Copper is a well-known antimicrobial and antiviral agent; however, the underlying molecular mechanisms by which copper causes cell death are not yet fully understood.<\/jats:p>","DOI":"10.1128\/mbio.03251-21","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T08:35:41Z","timestamp":1647333341000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":118,"title":["Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones"],"prefix":"10.1128","volume":"13","author":[{"given":"Lisa","family":"Zuily","sequence":"first","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS, BIP, UMR 7281, IMM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Lahrach","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS, BIP, UMR 7281, IMM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosi","family":"Fassler","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-2827","authenticated-orcid":true,"given":"Olivier","family":"Genest","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS, BIP, UMR 7281, IMM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8013-0806","authenticated-orcid":true,"given":"Peter","family":"Faller","sequence":"additional","affiliation":[{"name":"Biometals and Biology Chemistry, Institut de Chimie (CNRS UMR7177), Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-5528","authenticated-orcid":true,"given":"Olivier","family":"S\u00e9n\u00e8que","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, CNRS, CEA, IRIG\/DIESE, LCBM (UMR 5249), Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Denis","sequence":"additional","affiliation":[{"name":"Plateforme Transcriptome, Aix-Marseille Universit\u00e9, CNRS, IMM-FR3479, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9889-1101","authenticated-orcid":true,"given":"Marie-Pierre","family":"Castani\u00e9-Cornet","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie et G\u00e9n\u00e9tique Mol\u00e9culaires, Centre de Biologie Int\u00e9grative, Universit\u00e9 de Toulouse, CNRS, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7539-3126","authenticated-orcid":true,"given":"Pierre","family":"Genevaux","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie et G\u00e9n\u00e9tique Mol\u00e9culaires, Centre de Biologie Int\u00e9grative, Universit\u00e9 de Toulouse, CNRS, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4020-4572","authenticated-orcid":true,"given":"Ursula","family":"Jakob","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0315-5334","authenticated-orcid":true,"given":"Dana","family":"Reichmann","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Th\u00e9r\u00e8se","family":"Giudici-Orticoni","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS, BIP, UMR 7281, IMM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9070-2334","authenticated-orcid":true,"given":"Marianne","family":"Ilbert","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS, BIP, UMR 7281, IMM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867054637617"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3028"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14623"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.186"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7123"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.817452"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1068"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1579-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ampbs.2017.01.007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.07068-11"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b11561"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01357-06"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812808106"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01742-17"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00867-17"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1039\/c8mt00239h"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.0c00900"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/c5mt00011d"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007052"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3447-3"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1039\/c8mt00182k"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22344"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2015.08.005"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(98)90029-5"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1511"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku399"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep24554"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2004.06.008"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1039\/C0MT00044B"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux015"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/membranes10090242"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14522"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2011.02406.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.23.6842-6844.2000"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505742200"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05961.x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.694012"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0133-3"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.01.009"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014442"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.024"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01289-15"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00778-21"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00905a001"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02842-14"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01393-12"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-94439-5"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02804-20"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00543-13"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104122200"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.22.7815-7817.2004"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.01.084"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27650-0"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.010023"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00490-16"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-017-0748-x"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.10.558"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4MT00345D"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2009.09.021"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic001447b"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80547-4"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37623"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(82)90515-0"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/4.2.155"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.03251-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.03251-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T09:37:42Z","timestamp":1650965862000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.03251-21"}},"subtitle":[],"editor":[{"given":"Michael David Leslie","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4,26]]}},"alternative-id":["10.1128\/mbio.03251-21"],"URL":"https:\/\/doi.org\/10.1128\/mbio.03251-21","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"assertion":[{"value":"2022-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03251-21"}}