{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:50:29Z","timestamp":1779231029534,"version":"3.51.4"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017M2A2A7A01070813"],"award-info":[{"award-number":["NRF-2017M2A2A7A01070813"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1D1A1B03032322"],"award-info":[{"award-number":["NRF-2017R1D1A1B03032322"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1A2C1012207"],"award-info":[{"award-number":["NRF-2020R1A2C1012207"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,4,28]]},"abstract":"<jats:p>Abuse of antibiotics often leads to increase of multidrug-resistant (MDR) bacteria, which threatens the life of human beings. To overcome threat of antibiotic resistance, scientists are developing a novel class of antibiotics, antimicrobial peptides, that can eradicate MDR bacteria. Unfortunately, these antibiotics have mainly been developed to cure bacterial skin infections rather than others, such as life-threatening sepsis. Major pharmaceutical companies have tried to develop antiseptic drugs; however, they have not been successful. Here, we report that AMPR-11, the antimicrobial peptide (AMP) derived from mitochondrial nonselective channel Romo1, has antimicrobial activity against Gram-positive and Gram-negative bacteria comprising many clinically isolated MDR strains. Moreover, AMPR-11 increased the survival rate in a murine model of sepsis caused by MDR bacteria. We propose that AMPR-11 could be a novel antiseptic drug candidate with a broad antimicrobial spectrum to overcome MDR bacterial infection.<\/jats:p>","DOI":"10.1128\/mbio.03258-19","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T13:41:03Z","timestamp":1586785263000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Romo1-Derived Antimicrobial Peptide Is a New Antimicrobial Agent against Multidrug-Resistant Bacteria in a Murine Model of Sepsis"],"prefix":"10.1128","volume":"11","author":[{"given":"Hye-Ra","family":"Lee","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Cell Biology, Graduate School of Medicines, Korea University College of Medicine, Korea University, Seoul, Republic of Korea"},{"name":"Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deok-gyun","family":"You","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology, Graduate School of Medicines, Korea University College of Medicine, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang Wook","family":"Sohn","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2125-7521","authenticated-orcid":false,"given":"Min Ja","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Kuk","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gi Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology, Graduate School of Medicines, Korea University College of Medicine, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Do","family":"Yoo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology, Graduate School of Medicines, Korea University College of Medicine, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/9781555817886"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.06.009"},{"key":"e_1_3_2_4_2","first-page":"1","article-title":"Antimicrobial resistance: tackling a crisis for the health and wealth of nations","volume":"20","author":"O\u2019Neill J","year":"2014","unstructured":"O\u2019Neill J. 2014. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. Rev Antimicrob Resist 20:1\u201316.","journal-title":"Rev Antimicrob Resist"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.13.12"},{"key":"e_1_3_2_6_2","volume-title":"Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics","author":"Tacconelli E","year":"2017","unstructured":"Tacconelli E, Magrini N, Kahlmeter G, Singh N. 2017. Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit070"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2017.03.014"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu296"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/497143"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.embor748"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2017.1315402"},{"key":"e_1_3_2_13_2","volume-title":"Antimicrobial cationic peptides\u2014advances in research and application, 2013 edition","author":"Acton QA","year":"2013","unstructured":"Acton QA, ed. 2013. Antimicrobial cationic peptides\u2014advances in research and application, 2013 edition. ScholarlyEditions, Atlanta, Georgia."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040319"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8153620"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb020574"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441001"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200301000-00002"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5085-0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0934-2"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181e96b91"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules171012276"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.19"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.06.140"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.02.098"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201709001"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.13.4443"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000041107"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1994.0015"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.05.015"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja991829k"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12831"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm253"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000799"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.26083"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.09.004"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3208-3216.2005"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00404"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117147109"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.32.22445"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/5.2.101"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.12.3.7873202"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/167572"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/809283"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.31.2.164"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470600122"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1086\/593185"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.Supplement_1.S151"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S55778"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00168"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00369-11"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516679973"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.76.528"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2002.129.pl6"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.10.014"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.03258-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.03258-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T02:51:48Z","timestamp":1646707908000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.03258-19"}},"subtitle":[],"editor":[{"given":"Sang Yup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,28]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4,28]]}},"alternative-id":["10.1128\/mBio.03258-19"],"URL":"https:\/\/doi.org\/10.1128\/mbio.03258-19","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,28]]},"assertion":[{"value":"2019-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03258-19"}}