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The disease is caused by protozoan parasites of the genus\n            <jats:italic>Plasmodium<\/jats:italic>\n            , and of the five species capable of infecting humans, infections with\n            <jats:named-content content-type=\"genus-species\">P. falciparum<\/jats:named-content>\n            are the most severe. In addition to the parasites that infect people, there are hundreds of additional species that infect birds, reptiles, and other mammals, each exquisitely evolved to meet the specific challenges inherent to survival within their respective hosts. By comparing the unique strategies that each species has evolved, key insights into host-parasite interactions can be gained, including discoveries regarding the pathogenesis of human disease. Here, we describe the surprising observation that closely related parasites with different hosts have evolved remarkably different methods for repairing their genomes. This observation has important implications for the ability of parasites to maintain chronic infections and for the development of host immunity.\n          <\/jats:p>","DOI":"10.1128\/mbio.03272-19","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T12:01:10Z","timestamp":1584360070000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3600-9483","authenticated-orcid":false,"given":"Michelle C.","family":"Siao","sequence":"first","affiliation":[{"name":"Tri-Institutional MD-PhD Program, Weill Cornell Medical College, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janus","family":"Borner","sequence":"additional","affiliation":[{"name":"Sackler Institute for Comparative Genomics &amp; Division of Invertebrate Zoology, American Museum of Natural History, New York, New York, USA"},{"name":"Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Sackler Institute for Comparative Genomics &amp; Division of Invertebrate Zoology, American Museum of Natural History, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9183-2480","authenticated-orcid":false,"given":"Kirk W.","family":"Deitsch","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4085-5540","authenticated-orcid":false,"given":"Laura A.","family":"Kirkman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA"},{"name":"Department of Internal Medicine, Division of Infectious Diseases, Weill Cornell Medical College, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","volume-title":"Through the looking-glass and what Alice found there","author":"Carroll L","year":"1900","unstructured":"Carroll L. 1900. 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