{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:15:37Z","timestamp":1790655337475,"version":"4.1.0"},"reference-count":75,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2021R1A2B5B03086596, 2021M3A9I4021434, 2018R1A5A1025077"],"award-info":[{"award-number":["2021R1A2B5B03086596, 2021M3A9I4021434, 2018R1A5A1025077"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Yonsei Signature Research Cluster Program","award":["2023-22-0012"],"award-info":[{"award-number":["2023-22-0012"]}]},{"name":"National Institute of Health (NIH)\/National Institute of Allergy and Infectious Disease","award":["AI039115-26, AI050113-19"],"award-info":[{"award-number":["AI039115-26, AI050113-19"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2024,2,14]]},"abstract":"<jats:p>\n                    The casein kinase 2 (CK2) complex, crucial for eukaryotic growth, differentiation, and metabolic regulation, presents a promising therapeutic target for various human diseases, including cancer, diabetes, and obesity. Its potential as an antifungal target is further highlighted in this study, which explores CK2\u2019s functions in\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    , a key fungal meningitis pathogen. The CK2 complex in\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    , comprising the Cka1 catalytic subunit and Ckb1\/2 regulatory subunits, is integral to processes like growth, cell cycle, morphogenesis, stress response, drug resistance, and virulence. Our findings of CK2\u2019s role in regulating critical signaling pathways, including Hog1, Mpk1 MAPKs, cAMP\/PKA, and calcium\/calcineurin, underscore its importance in\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    pathogenicity. This study provides valuable insights into the fungal CK2 complex, reinforcing its potential as a target for novel antifungal drug development and pointing out a promising direction for creating new antifungal agents.\n                  <\/jats:p>","DOI":"10.1128\/mbio.03275-23","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T09:01:51Z","timestamp":1704790911000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Casein kinase 2 complex: a central regulator of multiple pathobiological signaling pathways in\n                    <i>Cryptococcus neoformans<\/i>"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-902X","authenticated-orcid":false,"given":"Yeseul","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0025-3860","authenticated-orcid":false,"given":"Seong-Ryong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6991-0967","authenticated-orcid":false,"given":"Yujin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0089-3817","authenticated-orcid":false,"given":"Ann-Yae","family":"Na","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University, Suwon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-701X","authenticated-orcid":false,"given":"Sangkyu","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University, Suwon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-5995","authenticated-orcid":false,"given":"Joseph","family":"Heitman","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1737-686X","authenticated-orcid":false,"given":"Ran","family":"Seo","sequence":"additional","affiliation":[{"name":"AmtixBio Co., Ltd., Hanam-si, Gyeonggi-do, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-9160","authenticated-orcid":false,"given":"Han-Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"AmtixBio Co., Ltd., Hanam-si, Gyeonggi-do, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6257-331X","authenticated-orcid":false,"given":"Jong-Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"AmtixBio Co., Ltd., Hanam-si, Gyeonggi-do, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9573-5752","authenticated-orcid":false,"given":"Yong-Sun","family":"Bahn","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2005.07.008"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20021469"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.19.5320"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep03460"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2017.00097"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00567-7"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.034"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01076770"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013188101465"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008583200"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi962885q"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802065105"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-005-3111-3"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-9150-2"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37471-9"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.2016-064"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.10"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210924"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000780"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-020-00566-w"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-1356(03)00110-7"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.3.521"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013189629207"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03836.x"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002562"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-017-3068-z"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof8070734"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00511-0"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12766"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50678-z"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.037770.108"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13302"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.1.190-201.2005"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.7.3842-3850.2005"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15329-2"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-02-0113"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2012.02.001"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005113"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-11-0987"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00218-13"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26405-5"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058956"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005873"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof9020252"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0079-6603(08)61030-2"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00784.x"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1628"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058008"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24887"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.43.25905"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.10.5869"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.11.089"},{"key":"e_1_3_6_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13736"},{"key":"e_1_3_6_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9101361"},{"key":"e_1_3_6_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja103954u"},{"key":"e_1_3_6_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54934-6"},{"key":"e_1_3_6_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01563-08"},{"key":"e_1_3_6_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.30.19183"},{"key":"e_1_3_6_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00025a019"},{"key":"e_1_3_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.02.011"},{"key":"e_1_3_6_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2165"},{"key":"e_1_3_6_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2008.07.002"},{"key":"e_1_3_6_64_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.20.12961"},{"key":"e_1_3_6_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04562.x"},{"key":"e_1_3_6_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1867-1"},{"key":"e_1_3_6_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-539-8_5"},{"key":"e_1_3_6_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpmc.59"},{"key":"e_1_3_6_69_2","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2017.0096"},{"key":"e_1_3_6_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.095"},{"key":"e_1_3_6_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_6_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-5362-x"},{"key":"e_1_3_6_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_6_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz247"},{"key":"e_1_3_6_75_2","unstructured":"Blighe K Rana S Lewis M. 2019. EnhancedVolcano: publication-ready volcano plots with enhanced colouring and labeling. R package version 1."},{"key":"e_1_3_6_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1038"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.03275-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.03275-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T14:25:34Z","timestamp":1723386334000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.03275-23"}},"subtitle":[],"editor":[{"given":"Gustavo H.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,2,14]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,14]]}},"alternative-id":["10.1128\/mbio.03275-23"],"URL":"https:\/\/doi.org\/10.1128\/mbio.03275-23","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,14]]},"assertion":[{"value":"2023-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03275-23"}}