{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:23:35Z","timestamp":1789431815740,"version":"build-2803163510"},"reference-count":87,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI127548"],"award-info":[{"award-number":["R01 AI127548"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL122372"],"award-info":[{"award-number":["R01 HL122372"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM008704"],"award-info":[{"award-number":["T32GM008704"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM113132"],"award-info":[{"award-number":["GM113132"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["STANTO19R0"],"award-info":[{"award-number":["STANTO19R0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["ASHARE20P0"],"award-info":[{"award-number":["ASHARE20P0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA023108"],"award-info":[{"award-number":["CA023108"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI133956"],"award-info":[{"award-number":["AI133956"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["MRI-1429826"],"award-info":[{"award-number":["MRI-1429826"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"HHS | NIH | NIH Office of the Director","doi-asserted-by":"publisher","award":["1S10OD016290-01A1"],"award-info":[{"award-number":["1S10OD016290-01A1"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK117469"],"award-info":[{"award-number":["DK117469"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2021,4,27]]},"abstract":"<jats:p>\n                    Understanding microbial evolution within patients is critical for managing chronic infections and understanding host-pathogen interactions. Here, our analysis of multiple\n                    <jats:italic>MRR1<\/jats:italic>\n                    alleles in isolates from a single\n                    <jats:italic>Clavispora<\/jats:italic>\n                    (\n                    <jats:italic>Candida<\/jats:italic>\n                    )\n                    <jats:italic>lusitaniae<\/jats:italic>\n                    infection revealed the selection for both high and low Mrr1 activity.\n                  <\/jats:p>","DOI":"10.1128\/mbio.03328-20","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T08:35:53Z","timestamp":1616834153000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Balancing Positive and Negative Selection:\n                    <i>In Vivo<\/i>\n                    Evolution of Candida lusitaniae\n                    <i>MRR1<\/i>"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-7430","authenticated-orcid":true,"given":"Elora G.","family":"Demers","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-0020","authenticated-orcid":true,"given":"Jason E.","family":"Stajich","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Plant Pathology and Institute for Integrative Genome Biology, University of California\u2014Riverside, Riverside, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2413-5845","authenticated-orcid":true,"given":"Alix","family":"Ashare","sequence":"additional","affiliation":[{"name":"Dartmouth-Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, Lebanon, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Occhipinti","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-2971","authenticated-orcid":true,"given":"Deborah A.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2019.06.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00473-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.1035"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.11.095"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12954"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.01.008"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.997"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2848"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/010421-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1807698115"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02821.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(03)00094-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02204-15"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-3-7611"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A077"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00325-11"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/344651"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780801968571"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.10.019"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1534\/g3.116.034744"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03364-19"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008921"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.12.3065"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030164"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00740-08"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06309.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1086-6"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00842-15"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02512-19"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20183-3"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(88)90559-8"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01343-10"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.29277-0"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.05100-11"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.8.3064-3079.2004"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2017.10.003"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14604"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-146-11-2743"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006655"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1879-1881.2001"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx270"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00584-17"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-23"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2015-0271"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.7.1819"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.3.617"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.38.5.1123"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0740-0020(90)90036-H"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2019.01.001"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr9005074"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104554"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01129205"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13807"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00146a011"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-2836(61)80004-1"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.166.3906.755"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00351735"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64562-4"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/15.11.2421"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01846-15"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150859"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.48.5.1600-1613.2004"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00218-17"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-08-0546"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-06-0501"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01001-20"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00199"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0322-2"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.3427"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07779-6"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01344-17"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01467-10"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.6.557"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199410000-00013"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.03.004"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149998"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.2.1239-1242.2005"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00130-16"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.1813"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(92)90454-w"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00682-06"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08064"},{"key":"e_1_3_2_84_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts; CLSI document M27-S4.","author":"CLSI","year":"2012","unstructured":"CLSI. 2012. Reference method for broth dilution antifungal susceptibility testing of yeasts; CLSI document M27-S4. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3578-9_15"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_3_2_88_2","unstructured":"Kolde R 2019. pheatmap: Pretty heatmaps. R package version 1.0.12. https:\/\/rdrr.io\/cran\/pheatmap\/."}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.03328-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.03328-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T22:26:52Z","timestamp":1646692012000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.03328-20"}},"subtitle":[],"editor":[{"given":"James W.","family":"Kronstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,27]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4,27]]}},"alternative-id":["10.1128\/mBio.03328-20"],"URL":"https:\/\/doi.org\/10.1128\/mbio.03328-20","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.11.30.405712","asserted-by":"object"}]},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,27]]},"assertion":[{"value":"2020-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03328-20"}}