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This pathogen is unusually resistant to antifungals, threatening to overwhelm current management options. By screening a library of structurally diverse molecules, we found that\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            is surprisingly sensitive to translation inhibition by a class of compounds known as rocaglates (also known as flavaglines). Despite the high level of conservation across fungi in their protein synthesis machinery, these compounds inhibited translation initiation and activated a cell death program in\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            but not in its relative\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            . Our findings highlight a surprising divergence across the cell death programs operating in\n            <jats:italic>Candida<\/jats:italic>\n            species and underscore the need to understand the specific biology of a pathogen in attempting to develop more-effective treatments against it.\n          <\/jats:p>","DOI":"10.1128\/mbio.03329-19","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T09:55:17Z","timestamp":1583747717000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris"],"prefix":"10.1128","volume":"11","author":[{"given":"Kali R.","family":"Iyer","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Whitesell","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John A.","family":"Porco","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Henkel","sequence":"additional","affiliation":[{"name":"IMAX Discovery GmbH, Dortmund, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah E.","family":"Cowen","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00083.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2019.103243"},{"key":"e_1_3_2_4_2","unstructured":"Centers for Disease Control and Prevention. 2019. 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