{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:26:24Z","timestamp":1791973584852,"version":"4.4.0"},"reference-count":85,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["BSCGIO 157841"],"award-info":[{"award-number":["BSCGIO 157841"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["TL1TR001447"],"award-info":[{"award-number":["TL1TR001447"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI22285"],"award-info":[{"award-number":["U01AI22285"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR00144"],"award-info":[{"award-number":["UL1 TR00144"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR002386-02"],"award-info":[{"award-number":["TL1TR002386-02"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2021,2,23]]},"abstract":"<jats:p>The assembly of microbial communities that populate all mucosal surfaces of the human body begins right after birth. This process is prone to disruption as newborns and young infants are increasingly exposed to antibiotics, both deliberately for therapeutic purposes, and as a consequence of transmaternal exposure.<\/jats:p>","DOI":"10.1128\/mbio.03335-20","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T01:35:01Z","timestamp":1612143301000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":66,"title":["An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses"],"prefix":"10.1128","volume":"12","author":[{"given":"Xiaozhou","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Borbet","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Fallegger","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Wipperman","sequence":"additional","affiliation":[{"name":"Immunology Program, Sloan Kettering Institute, New York, USA"},{"name":"Clinical and Translational Science Center, Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-2443","authenticated-orcid":false,"given":"Martin J.","family":"Blaser","sequence":"additional","affiliation":[{"name":"Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.017"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06245"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4142"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317503"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.50"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155725"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124234"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3282f2b0e8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002533"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058709"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00426"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02820-19"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1898-4"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.022"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1865-0"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay0618"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0617-x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36521"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.01.011"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad7121"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.04.011"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091334"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0308-z"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.10.022"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02573-2"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1182293"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.06.009"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.052"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-019-0349-4"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0297-9"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.140"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37816"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.2905"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502322"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00984-19"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1560-1"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3542"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.03.005"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32470-5"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix654"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00201.x"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0075-5"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120822"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa9420"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.01.016"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.61.6.2486-2492.1993"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3315"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.033"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198469"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.021"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007866"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25500"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.013"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008051"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080414"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070590"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.54"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001672"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06423-7"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12726"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12721"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.08.012"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.26"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0193"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12079"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10434"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.092"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241165"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01995"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4263"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0461-z"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0031-y"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2020.12.1.137"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.32"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1731"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22360"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00531-6"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8486"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00009-15"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10346-6"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31827f520f"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12356"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.03335-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.03335-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T22:21:57Z","timestamp":1646691717000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.03335-20"}},"subtitle":[],"editor":[{"given":"Jacques","family":"Ravel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2,23]]}},"alternative-id":["10.1128\/mBio.03335-20"],"URL":"https:\/\/doi.org\/10.1128\/mbio.03335-20","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]},"assertion":[{"value":"2020-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03335-20"}}