{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:41:37Z","timestamp":1792503697494,"version":"4.5.0"},"reference-count":89,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA059952, R01AI187175, R01DA055488, R01DA051889, 5P30AI042853, U54AI170660"],"award-info":[{"award-number":["R01DA059952, R01AI187175, R01DA055488, R01DA051889, 5P30AI042853, U54AI170660"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Suppressive antiretroviral therapy (ART) in people with HIV (PWH) arrests progression to AIDS and onward viral transmission. However, viral transcription from integrated HIV-1 proviruses persists on treatment and is linked to markers of chronic immune activation, contributing to the accelerated development of comorbidities in PWH. Of particular interest are persistent responses in long-lived tissue-resident myeloid cells, which direct tissue-level inflammatory processes through cytokine secretion and interactions with other immune cell populations. Here, we review recent findings on viral nucleic acid sensing events in HIV-infected myeloid cells to shed light on possible mechanisms of persistent inflammation resulting from chronic HIV-1 transcription in myeloid cells in PWH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.03340-25","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:02:38Z","timestamp":1792501358000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["mGem: Innate immune sensing of HIV-1 transcription in myeloid cells\u2014a tale of two transcription start sites"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8769-4011","authenticated-orcid":true,"given":"Ivy K.","family":"Hughes","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05qwgg493","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Virology, Immunology, & Microbiology, 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