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Differences between murine and human immunity and the low level of complexity of traditional cell cultures, however, highlight the demand for alternative models that combine the\n            <jats:italic>in vivo<\/jats:italic>\n            -like properties of the human system with straightforward experimental perturbation. Here, we introduce a 3D tissue model comprising multiple cell types of the human intestinal barrier, a primary site of pathogen attack. During infection with the foodborne pathogen\n            <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n            serovar Typhimurium, our model recapitulates human disease aspects, including pathogen restriction to the epithelial compartment, thereby deviating from the systemic infection in mice. Combination of our model with state-of-the-art genetics revealed\n            <jats:italic>Salmonella<\/jats:italic>\n            -mediated local manipulations of human immune responses, likely contributing to the establishment of the pathogen\u2019s infection niche. We propose the adoption of similar 3D tissue models to infection biology, to advance our understanding of molecular infection strategies employed by bacterial pathogens in their human host.\n          <\/jats:p>","DOI":"10.1128\/mbio.03348-19","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T13:09:17Z","timestamp":1581944957000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["An Advanced Human Intestinal Coculture Model Reveals Compartmentalized Host and Pathogen Strategies during\n            <i>Salmonella<\/i>\n            Infection"],"prefix":"10.1128","volume":"11","author":[{"given":"Leon N.","family":"Schulte","sequence":"first","affiliation":[{"name":"Institute of Molecular Infection Biology (IMIB), University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Institute for Lung Research, Philipps University, Marburg, 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