{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:57:33Z","timestamp":1787615853837,"version":"build-2736575974"},"reference-count":68,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070130"],"award-info":[{"award-number":["32070130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772148"],"award-info":[{"award-number":["81772148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31820103002"],"award-info":[{"award-number":["31820103002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770144"],"award-info":[{"award-number":["31770144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871624"],"award-info":[{"award-number":["81871624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Distinguished Young Scholar of Tianjin","award":["20JCJQJC00180"],"award-info":[{"award-number":["20JCJQJC00180"]}]},{"name":"the Natural Science Foundation (Key Project) of Tianjin","award":["20JCZDJC00820"],"award-info":[{"award-number":["20JCZDJC00820"]}]},{"name":"National Key Programs for Infectious Diseases of China","award":["2017ZX10303405-001"],"award-info":[{"award-number":["2017ZX10303405-001"]}]},{"name":"National Key Programs for Infectious Diseases of China","award":["2018ZX10714002-001-006"],"award-info":[{"award-number":["2018ZX10714002-001-006"]}]},{"name":"National Key Programs for Infectious Diseases of China","award":["2017ZX10303405-001"],"award-info":[{"award-number":["2017ZX10303405-001"]}]},{"name":"National Key Programs for Infectious Diseases of China","award":["2018ZX10714002-001-006"],"award-info":[{"award-number":["2018ZX10714002-001-006"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2021,4,27]]},"abstract":"<jats:p>The process by which bacteria sense environmental cues to regulate their virulence is complex. Several studies have focused on regulating the expression of the locus of enterocyte effacement pathogenicity island in the typical gut pathogenic bacterium, O157.<\/jats:p>","DOI":"10.1128\/mbio.03605-20","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T13:31:50Z","timestamp":1615815110000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["A Novel Small RNA Promotes Motility and Virulence of Enterohemorrhagic\n            <i>Escherichia coli<\/i>\n            O157:H7 in Response to Ammonium"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7868-8517","authenticated-orcid":true,"given":"Tianyuan","family":"Jia","sequence":"first","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"},{"name":"Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqian","family":"Mu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqian","family":"Qian","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxing","family":"Li","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gege","family":"Lu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Guo","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"},{"name":"Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"},{"name":"Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Huang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"},{"name":"Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Feng","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"},{"name":"Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People\u2019s Republic of China"},{"name":"Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Tianjin, People\u2019s Republic of China"},{"name":"Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198303243081203"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.091101p2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304978110"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11623"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01429-18"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.19182"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1537100100"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1051\/vetres\/2010029"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.10.032"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.EHEC-0003-2013"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00464-07"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01244.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00336-12"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161737"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1887"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00208"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15071-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.02.068"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.ESP-0030-2019"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7100422"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003798"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902725116"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00274"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnw262"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.04.002"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.004"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky096"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02918-14"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.08.003"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-020518-115931"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.03.002"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.05.004"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.11.005"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-20215-0_12"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7592"},{"key":"e_1_3_2_38_2","first-page":"1090","article-title":"Using RNAFOLD to predict the activity of small catalytic RNAs","volume":"15","author":"Denman RB","year":"1993","unstructured":"Denman RB. 1993. Using RNAFOLD to predict the activity of small catalytic RNAs. Biotechniques 15:1090\u20131095.","journal-title":"Biotechniques"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201061109"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.229"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-420120-0.00004-9"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.05.006"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2019.1672514"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku317"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134884"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.633677"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068384"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-809633-8.20680-8"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90553-2"},{"key":"e_1_3_2_50_2","first-page":"94","article-title":"Comparative study on caecal fermentation pattern in adult domestic rabbits and wild hares","volume":"15","author":"Marounek M","year":"2013","unstructured":"Marounek M, Mi\u015bta D, Volek Z, Savka O, Kalachnyuk L, Kalachnyuk GI. 2013. Comparative study on caecal fermentation pattern in adult domestic rabbits and wild hares. Anim Biol 15:94\u2013101.","journal-title":"Anim Biol"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.150.1.202-213.1982"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00568"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00881-13"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1134\/S000629791511005X"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1836-1846.2005"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2012.12.003"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.26.14674"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.12272"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.074773-0"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00773"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06875.x"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04637-3"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.57.4.1290-1298.1989"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12651"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006429"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-949-5_15"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0721-2"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst010"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.03605-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.03605-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:30:27Z","timestamp":1646710227000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.03605-20"}},"subtitle":[],"editor":[{"given":"Melissa M.","family":"Kendall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Gerald B.","family":"Pier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,27]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4,27]]}},"alternative-id":["10.1128\/mBio.03605-20"],"URL":"https:\/\/doi.org\/10.1128\/mbio.03605-20","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,27]]},"assertion":[{"value":"2020-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03605-20"}}