{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:15:39Z","timestamp":1789107339780,"version":"build-2803163510"},"reference-count":73,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI33537"],"award-info":[{"award-number":["AI33537"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI151313"],"award-info":[{"award-number":["AI151313"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI55449"],"award-info":[{"award-number":["AI55449"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:p>\n                    Infection with\n                    <jats:named-content content-type=\"genus-species\">B. anthracis<\/jats:named-content>\n                    can result in systemic disease with large numbers of the bacterium in multiple tissues. We found that branched-chain amino acid (BCAA) synthesis is insufficient for the robust growth of\n                    <jats:named-content content-type=\"genus-species\">B. anthracis<\/jats:named-content>\n                    ; access to BCAAs is necessary for the proliferation of the pathogen during culture and during infection in a murine model for anthrax.\n                    <jats:named-content content-type=\"genus-species\">B. anthracis<\/jats:named-content>\n                    produces an unusually large repertoire of BCAA-related transporters.\n                  <\/jats:p>","DOI":"10.1128\/mbio.03640-21","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T04:30:51Z","timestamp":1643085051000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["BrnQ-Type Branched-Chain Amino Acid Transporters Influence Bacillus anthracis Growth and Virulence"],"prefix":"10.1128","volume":"13","author":[{"given":"Soumita","family":"Dutta","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana D.","family":"Corsi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA"},{"name":"MD Anderson UTHealth Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Bier","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA"},{"name":"MD Anderson UTHealth Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa M.","family":"Koehler","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA"},{"name":"MD Anderson UTHealth Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05469.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-091014-104523"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2011.08.016"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.610036"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14413"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00690-13"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2018.06.024"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-011-9413-x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8030069"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.39.1.483-486.1983"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(88)65019-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01586"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01347-08"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.15.4288-4295.2002"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13961"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13495"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2011.00812.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01188-18"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.042358-0"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-017-0931-0"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02542-14"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01543-08"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00849"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.05.006"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.304311"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.619163"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007159"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418038"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.02563-14"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002030050576"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.9.3280-3289.2006"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.793"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00073-15"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftv061"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.17.5329-5338.1993"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.tb02340.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.2.307-315.2004"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00776-12"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00569-19"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07843.x"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01656-09"},{"key":"e_1_3_3_43_2","first-page":"189","article-title":"Inter-relationships between amino-acids in the nutrition of B. anthracis","volume":"20","author":"Gladstone GP","year":"1939","unstructured":"Gladstone GP. 1939. Inter-relationships between amino-acids in the nutrition of B. anthracis. Br J Exp Pathol 20:189\u2013200.","journal-title":"Br J Exp Pathol"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/010355-0"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-17-2-505"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.79.3.450-455.1960"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04634.x"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-146-8-1775"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00983"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01333-06"},{"key":"e_1_3_3_51_2","first-page":"166","article-title":"TMBASE\u2014a database of membrane spanning protein segments","volume":"374","author":"Hofmann K","year":"1993","unstructured":"Hofmann K. 1993. TMBASE\u2014a database of membrane spanning protein segments. Biol Chem Hoppe Seyler 374:166.","journal-title":"Biol Chem Hoppe Seyler"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.3.586-595.1994"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.6.2627-2630.2000"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-018-0095-9"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13020098"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/insects5010062"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007283"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.tb02378.x"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.02041-12"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00716-09"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-330"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00671-09"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1089"},{"key":"e_1_3_3_64_2","doi-asserted-by":"crossref","unstructured":"Passalacqua KD Zhou T Washington TA Abuaita BH Sonenshein AL O\u2019Riordan MXD. 2020. The branched chain aminotransferase IlvE promotes growth stress resistance and pathogenesis of Listeria monocytogenes . bioRxiv https:\/\/doi.org\/10.1101\/2020.01.31.929828.","DOI":"10.1101\/2020.01.31.929828"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00415-21"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)00647-b"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.62.3.293-300.1951"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00482"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(89)90359-4"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/br.32.4_pt_1.358-361.1968"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00917-13"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-147-6-1677"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(89)90358-2"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.03640-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.03640-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T23:09:14Z","timestamp":1646694554000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.03640-21"}},"subtitle":[],"editor":[{"given":"Jimmy D.","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,22]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2,22]]}},"alternative-id":["10.1128\/mbio.03640-21"],"URL":"https:\/\/doi.org\/10.1128\/mbio.03640-21","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.09.472043","asserted-by":"object"}]},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,22]]},"assertion":[{"value":"2021-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03640-21"}}