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Here we propose the Guild Model for Cystic Fibrosis Airway Microbial Ecology, which considers the ecological function and wider role of each microbe in the ecosystem. This model consists of four functional guilds: (i) \u201cBrewers\u201d metabolize host-derived substrates (e.g., mucins) and produce fermentation products; (ii) \u201cDrunkards\u201d exploit the metabolic niche built by Brewers, consuming fermentation products and secreting exopolysaccharides to build biofilms; (iii) \u201cPutrifiers\u201d produce toxic compounds causing inflammation and tissue necrosis; and (iv) \u201cNihilists\u201d are specialist pathogens characterized by intracellular or lytic life cycles and cytotoxin production. By focusing on microbial function and the broader community context, this model offers a refined framework for interpreting cystic fibrosis airway ecology. Although developed for CF, the Guild Model is adaptable to other diseases influenced by microbial ecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.03668-25","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:00:28Z","timestamp":1777554028000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["The Guild Model of CF Airway Microbial Ecology"],"prefix":"10.1128","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6338-5038","authenticated-orcid":true,"given":"Sage J. 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