{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:39:20Z","timestamp":1778647160914,"version":"3.51.4"},"reference-count":83,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2022,4,26]]},"abstract":"<jats:p>\n            The single-cell parasite\n            <jats:named-content content-type=\"genus-species\">Trypanosoma brucei<\/jats:named-content>\n            causes the fatal disease human African trypanosomiasis and is able to colonize the blood, fat, skin, and central nervous system. Trypanosomes survive in the mammalian host owing to a dense protective protein coat that consists of a single-variant surface glycoprotein species.\n          <\/jats:p>","DOI":"10.1128\/mbio.03847-21","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T11:45:04Z","timestamp":1646135104000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei"],"prefix":"10.1128","volume":"13","author":[{"given":"Emilia Jane","family":"McLaughlin","sequence":"first","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris, Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, Paris, France"},{"name":"Universit\u00e9 de Paris, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karinna","family":"Rubio-Pena","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris, Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annick","family":"Dujeancourt-Henry","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris, Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-6890","authenticated-orcid":true,"given":"Lucy","family":"Glover","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris, Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.17716"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04224.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112642"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2014.06.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0619-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003527"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Marcello L Barry JD. 2007. Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure 1344\u20131352. doi:10.1101\/gr.6421207.","DOI":"10.1101\/gr.6421207"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/414759a"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.3.542-551.2003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2018.02.013"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.21.12328"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200607174"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00281-09"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00282-09"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004545"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1469"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1905120116"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600344113"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10823-8"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00833-4"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01975.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-6851(96)02794-6"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01383.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07982"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003260"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.9.5839"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(83)80034-5"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007729"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky928"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01352-21"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.049"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.602956"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12765"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025313"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000992"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(88)90079-5"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002900"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.60"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001287"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13838"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1905552116"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5269.1795"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-6851(97)02853-3"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007532"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00959-w"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2690-2697.2005"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02324"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(02)00003-8"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501886102"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/319602a0"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.10.2332"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-1-2"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005994"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1265"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1100"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.111"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1309"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4502"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.24.7422"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90094-2"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3961"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.04.009"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3152"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.265"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-6851(98)00099-1"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.1.198"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.7.1491"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00547-17"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000992"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12093"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku942"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.2307\/3282883"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.11.2902"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.02.008"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.95.1.49"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.100998"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr703"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.03847-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.03847-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T13:42:09Z","timestamp":1650980529000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.03847-21"}},"subtitle":[],"editor":[{"given":"Stephen L.","family":"Hajduk","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":83,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4,26]]}},"alternative-id":["10.1128\/mbio.03847-21"],"URL":"https:\/\/doi.org\/10.1128\/mbio.03847-21","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"assertion":[{"value":"2022-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03847-21"}}