{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:46:42Z","timestamp":1793404002682,"version":"4.5.0"},"reference-count":39,"publisher":"Informa UK Limited","issue":"21","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Mol Cell Biol"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1128\/mcb.00112-09","type":"journal-article","created":{"date-parts":[[2009,8,24]],"date-time":"2009-08-24T21:41:14Z","timestamp":1251150074000},"page":"5872-5888","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":218,"title":["The Small Molecule GMX1778 Is a Potent Inhibitor of NAD\n                    <sup>+<\/sup>\n                    Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors"],"prefix":"10.1080","volume":"29","author":[{"given":"Mark","family":"Watson","sequence":"first","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Roulston","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Be\u0301lec","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Billot","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Marcellus","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Be\u0301dard","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Bernier","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ste\u0301phane","family":"Branchaud","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Chan","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenza","family":"Dairi","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Goulet","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel-Olivier","family":"Gratton","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henady","family":"Isakau","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Jang","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkrim","family":"Khadir","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Koch","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lawless","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Goodman Cancer Center, McGill University, Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Paquette","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E\u0301milie","family":"Turcotte","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin","family":"Berger","sequence":"additional","affiliation":[{"name":"Metabolon Inc.","place":["Durham, North Carolina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Metabolon Inc.","place":["Durham, North Carolina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon C.","family":"Shore","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]},{"name":"Department of Biochemistry and Goodman Cancer Center, McGill University, Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Beauparlant","sequence":"additional","affiliation":[{"name":"Gemin X Pharmaceuticals Canada Inc., Montre\u0301al","place":["Que\u0301bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200111000-00005"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e3283287c20"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1983.244.3.C288"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2005.3.533"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.073651"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112088"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986708783885282"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.318.5850.565b"},{"key":"e_1_3_2_10_1","first-page":"7436","article-title":"FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.","volume":"63","author":"Hasmann M.","year":"2003","unstructured":"Hasmann, M., and I. Schemainda. 2003. FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res. 63:7436\u20137442.","journal-title":"Cancer Res."},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00040-05"},{"key":"e_1_3_2_12_1","first-page":"5751","article-title":"CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo.","volume":"59","author":"Hjarnaa P. J.","year":"1999","unstructured":"Hjarnaa, P. J., E. Jonsson, S. Latini, S. Dhar, R. Larsson, E. Bramm, T. Skov, and L. Binderup. 1999. CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Res. 59:5751\u20135757.","journal-title":"Cancer Res."},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)01578-1"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006960126369"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.11.5.695"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1105"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.06.082"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.41.1.317"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5487.2126"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)00890-0"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.3.6.842"},{"key":"e_1_3_2_22_1","first-page":"4206","article-title":"Action of a novel anticancer agent, CHS 828, on mouse fibroblasts: increased sensitivity of cells lacking poly (ADP-Ribose) polymerase-1.","volume":"62","author":"L\u00f6vborg H.","year":"2002","unstructured":"L\u00f6vborg, H., J. Wojciechowski, R. Larsson, and J. Wesierska-Gadek. 2002. Action of a novel anticancer agent, CHS 828, on mouse fibroblasts: increased sensitivity of cells lacking poly (ADP-Ribose) polymerase-1. Cancer Res. 62:4206\u20134211.","journal-title":"Cancer Res."},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3161-1"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.019"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20255"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061638"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.7.5.5663"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408388200"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.09.003"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.2.1431-1437.1994"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210296200"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/73439"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1963"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10584"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1114"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.2.463"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2005000300006"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.2741\/2038"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1199904"}],"container-title":["Molecular and Cellular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/MCB.00112-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1128\/MCB.00112-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T21:03:16Z","timestamp":1770930196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1128\/MCB.00112-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":39,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1128\/MCB.00112-09"],"URL":"https:\/\/doi.org\/10.1128\/mcb.00112-09","relation":{},"ISSN":["1098-5549"],"issn-type":[{"value":"1098-5549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"2009-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-08-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}