{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:33:53Z","timestamp":1792409633584,"version":"4.4.0"},"reference-count":56,"publisher":"Informa UK Limited","issue":"12","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Biology"],"published-print":{"date-parts":[[2008,6,1]]},"DOI":"10.1128\/mcb.00289-08","type":"journal-article","created":{"date-parts":[[2008,4,14]],"date-time":"2008-04-14T20:45:16Z","timestamp":1208205916000},"page":"4104-4115","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":457,"title":["The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2"],"prefix":"10.1080","volume":"28","author":[{"given":"Jingxiang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C.","family":"Dibble","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan D.","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","volume":"15","author":"Alessi D. R.","year":"1996","journal-title":"EMBO J."},{"key":"R2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0065-230X(05)94002-5","volume":"94","author":"Bellacosa A.","year":"2005","journal-title":"Adv. Cancer Res."},{"key":"R3","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1038\/sj.onc.1204009","volume":"19","author":"Benvenuto G.","year":"2000","journal-title":"Oncogene"},{"key":"R4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.devcel.2007.03.020","volume":"12","author":"Bhaskar P. T.","year":"2007","journal-title":"Dev. Cell"},{"key":"R5","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1073\/pnas.97.11.6085","volume":"97","author":"Carsillo T.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"R6","doi-asserted-by":"crossref","first-page":"8313","DOI":"10.1074\/jbc.C500451200","volume":"281","author":"Chong-Kopera H.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"R7","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMra055323","volume":"355","author":"Crino P. B.","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"R8","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.cub.2006.08.001","volume":"16","author":"Frias M. A.","year":"2006","journal-title":"Curr. Biol."},{"key":"R9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ncb847","volume":"4","author":"Gao X.","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"R10","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S1097-2765(03)00220-X","volume":"11","author":"Garami A.","year":"2003","journal-title":"Mol. Cell"},{"key":"R11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","volume":"12","author":"Guertin D. A.","year":"2007","journal-title":"Cancer Cell"},{"key":"R12","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.devcel.2006.10.007","volume":"11","author":"Guertin D. A.","year":"2006","journal-title":"Dev. Cell"},{"key":"R13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0092-8674(02)00833-4","volume":"110","author":"Hara K.","year":"2002","journal-title":"Cell"},{"key":"R14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1083\/jcb.200403069","volume":"166","author":"Harrington L. S.","year":"2004","journal-title":"J. Cell Biol."},{"key":"R15","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cell.2005.10.024","volume":"123","author":"Holz M. K.","year":"2005","journal-title":"Cell"},{"key":"R16","doi-asserted-by":"crossref","first-page":"40406","DOI":"10.1074\/jbc.M508361200","volume":"280","author":"Hresko R. C.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"R17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng1494","volume":"37","author":"Inoki K.","year":"2005","journal-title":"Nat. Genet."},{"key":"R18","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","volume":"17","author":"Inoki K.","year":"2003","journal-title":"Genes Dev."},{"key":"R19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cell.2006.08.033","volume":"127","author":"Jacinto E.","year":"2006","journal-title":"Cell"},{"key":"R20","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.humpath.2007.01.028","volume":"38","author":"Kenerson H.","year":"2007","journal-title":"Hum. Pathol."},{"key":"R21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","volume":"110","author":"Kim D. H.","year":"2002","journal-title":"Cell"},{"key":"R22","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S1097-2765(03)00114-X","volume":"11","author":"Kim D. H.","year":"2003","journal-title":"Mol. Cell"},{"key":"R23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/hmg\/11.5.525","volume":"11","author":"Kwiatkowski D. J.","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"R24","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1073\/pnas.0511342103","volume":"103","author":"Liu H.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"R25","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1097-2765(02)00636-6","volume":"10","author":"Loewith R.","year":"2002","journal-title":"Mol. Cell"},{"key":"R26","doi-asserted-by":"crossref","first-page":"23433","DOI":"10.1074\/jbc.C500169200","volume":"280","author":"Long X.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"R27","doi-asserted-by":"crossref","first-page":"6416","DOI":"10.1038\/sj.onc.1209888","volume":"25","author":"Mamane Y.","year":"2006","journal-title":"Oncogene"},{"key":"R28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1083\/jcb.200408161","volume":"167","author":"Manning B. D.","year":"2004","journal-title":"J. Cell Biol."},{"key":"R29","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","volume":"129","author":"Manning B. D.","year":"2007","journal-title":"Cell"},{"key":"R30","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1101\/gad.1314605","volume":"19","author":"Manning B. D.","year":"2005","journal-title":"Genes Dev."},{"key":"R31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1097-2765(02)00568-3","volume":"10","author":"Manning B. D.","year":"2002","journal-title":"Mol. Cell"},{"key":"R32","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1038\/sj.emboj.7600218","volume":"23","author":"McManus E. J.","year":"2004","journal-title":"EMBO J."},{"key":"R33","doi-asserted-by":"crossref","first-page":"15461","DOI":"10.1074\/jbc.C200665200","volume":"278","author":"Nojima H.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"R34","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/BJ20070540","volume":"405","author":"Pearce L. R.","year":"2007","journal-title":"Biochem. J."},{"key":"R35","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.molcel.2007.03.003","volume":"25","author":"Sancak Y.","year":"2007","journal-title":"Mol. Cell"},{"key":"R36","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cub.2004.06.054","volume":"14","author":"Sarbassov D. D.","year":"2004","journal-title":"Curr. Biol."},{"key":"R37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molcel.2006.03.029","volume":"22","author":"Sarbassov D. D.","year":"2006","journal-title":"Mol. Cell"},{"key":"R38","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.1106148","volume":"307","author":"Sarbassov D. D.","year":"2005","journal-title":"Science"},{"key":"R39","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/ncb996","volume":"5","author":"Saucedo L. J.","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"R40","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0960-9822(02)00762-5","volume":"12","author":"Schalm S. S.","year":"2002","journal-title":"Curr. Biol."},{"key":"R41","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1128\/MCB.01254-05","volume":"26","author":"Shah O. J.","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"R42","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.cub.2004.08.026","volume":"14","author":"Shah O. J.","year":"2004","journal-title":"Curr. Biol."},{"key":"R43","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.devcel.2006.08.013","volume":"11","author":"Shiota C.","year":"2006","journal-title":"Dev. Cell"},{"key":"R44","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/ncb995","volume":"5","author":"Stocker H.","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"R45","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","volume":"13","author":"Tee A. R.","year":"2003","journal-title":"Curr. Biol."},{"key":"R46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1128\/MCB.26.1.63-76.2006","volume":"26","author":"Tzatsos A.","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"R47","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nature02866","volume":"431","author":"Um S. H.","year":"2004","journal-title":"Nature"},{"key":"R48","doi-asserted-by":"crossref","first-page":"25604","DOI":"10.1074\/jbc.M704343200","volume":"282","author":"Woo S. Y.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"R49","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","volume":"124","author":"Wullschleger S.","year":"2006","journal-title":"Cell"},{"key":"R50","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1101\/gad.1461206","volume":"20","author":"Yang Q.","year":"2006","journal-title":"Genes Dev."},{"key":"R51","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1073\/pnas.0602282103","volume":"103","author":"Yang Q.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"R52","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1172\/JCI28984","volume":"117","author":"Zhang H.","year":"2007","journal-title":"J. Clin. Investig."},{"key":"R53","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1172\/JCI200317222","volume":"112","author":"Zhang H.","year":"2003","journal-title":"J. Clin. Investig."},{"key":"R54","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molcel.2006.09.019","volume":"24","author":"Zhang H. H.","year":"2006","journal-title":"Mol. Cell"},{"key":"R55","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","volume":"5","author":"Zhang Y.","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"R56","doi-asserted-by":"crossref","first-page":"18443","DOI":"10.1073\/pnas.0508988102","volume":"102","author":"Zhao J. J.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Molecular and Cellular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/MCB.00289-08","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1128\/MCB.00289-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T10:30:51Z","timestamp":1679913051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1128\/MCB.00289-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,1]]},"references-count":56,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,6,1]]}},"alternative-id":["10.1128\/MCB.00289-08"],"URL":"https:\/\/doi.org\/10.1128\/mcb.00289-08","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1115144.571132","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1115144.793496372","asserted-by":"object"}]},"ISSN":["1098-5549"],"issn-type":[{"value":"1098-5549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,1]]},"assertion":[{"value":"2008-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}