{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:01:07Z","timestamp":1791500467111,"version":"4.3.4"},"reference-count":68,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Biology"],"published-print":{"date-parts":[[2013,1,1]]},"DOI":"10.1128\/mcb.01036-12","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T01:20:17Z","timestamp":1351560017000},"page":"194-212","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":260,"title":["Genomic and Proteomic Profiling Reveals Reduced Mitochondrial Function and Disruption of the Neuromuscular Junction Driving Rat Sarcopenia"],"prefix":"10.1080","volume":"33","author":[{"given":"Chikwendu","family":"Ibebunjo","sequence":"first","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Chick","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracee","family":"Kendall","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Eash","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Li","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Diseases, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Vickers","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Wu","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shi","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Cruz","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Fournier","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Brachat","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Gutzwiller","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QiCheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Markovits","sequence":"additional","affiliation":[{"name":"Preclinical Safety Sciences, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Broome","sequence":"additional","affiliation":[{"name":"Preclinical Safety Sciences, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Steinkrauss","sequence":"additional","affiliation":[{"name":"Preclinical Safety Sciences, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Skuba","sequence":"additional","affiliation":[{"name":"Preclinical Safety Sciences, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Rene","family":"Galarneau","sequence":"additional","affiliation":[{"name":"Preclinical Safety Sciences, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Gygi","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Glass","sequence":"additional","affiliation":[{"name":"Muscle Diseases Group, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh058"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.10.B359"},{"key":"B3","doi-asserted-by":"crossref","first-page":"E790","DOI":"10.1152\/ajpcell.1997.273.3.C790","volume":"273","author":"Balagopal P","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.clnu.2010.07.012","volume":"30","author":"Gray C","year":"2011","journal-title":"Clin. Nutr."},{"key":"B5","first-page":"11","volume":"50","author":"Lexell J","year":"1995","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B6","first-page":"545","volume":"25","author":"Nikolic M","year":"2001","journal-title":"Coll. Antropol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2009.01084.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05809.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.05.005"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0007-1"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-005-4808-0"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.11.1099"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.2.B108"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3084fje"},{"key":"B15","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1532-5415.2007.01228.x","volume":"55","author":"Arts IM","year":"2007","journal-title":"J. Am. Geriatr. Soc."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90332.2008"},{"key":"B17","first-page":"239","volume":"174","author":"Lexell J","year":"1991","journal-title":"J. Anat."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010778"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1040-7"},{"key":"B20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ddmec.2006.02.012","volume":"3","author":"Murphy CT","year":"2006","journal-title":"Drug Discov. Today Dis. Mechanisms"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3109\/10520298709107961"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9120(96)00003-6"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-1281(11)80344-2"},{"key":"B24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/01.ATV.0000251504.61247.d5","volume":"27","author":"Inoue N","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1177\/12.3.219"},{"key":"B26","volume-title":"Muscle biopsy: a practical approach","author":"Dubowitz V","year":"2007","edition":"3"},{"key":"B27","volume-title":"A language and environment for statistical computing","author":"Team RDC","year":"2004"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1080\/10618600.1996.10474713"},{"key":"B29","volume-title":"Guide to probe logarithmic intensity error (PLIER) estimation","author":"Affymetrix","year":"2005"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-10-r80"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800297"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1021\/ac0348625"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1021\/ac026117i"},{"key":"B37","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","volume":"5","author":"McCormack AL","year":"1994","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth1019"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.078873"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)64044-0"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(01)65006-4"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065874"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251541198"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00211-4"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163119"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/03610738008258359"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00299.2006"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150323"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1139\/H08-058"},{"key":"B50","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physiolgenomics.00249.2004","volume":"21","author":"Giresi PG","year":"2005","journal-title":"Physiol. Genomics"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081061898"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5432.1390"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00049.2003"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020115"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nature07206"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911570106"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607795103"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000068965.34812.62"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.178319"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp073"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00535.2003"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003686"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018090"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-630"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6604com"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/810619"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013984"},{"key":"B68","unstructured":"National Research Council. 1996. Guide for the care and use of laboratory animals. National Academies Press, Washington, DC."}],"container-title":["Molecular and Cellular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/MCB.01036-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1128\/MCB.01036-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T21:51:38Z","timestamp":1679349098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1128\/MCB.01036-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1,1]]}},"alternative-id":["10.1128\/MCB.01036-12"],"URL":"https:\/\/doi.org\/10.1128\/mcb.01036-12","relation":{},"ISSN":["1098-5549"],"issn-type":[{"value":"1098-5549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,1]]},"assertion":[{"value":"2012-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}