{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:45:57Z","timestamp":1791049557727,"version":"4.1.0"},"reference-count":57,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Biology"],"published-print":{"date-parts":[[2008,1,1]]},"DOI":"10.1128\/mcb.01404-07","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T23:00:12Z","timestamp":1193698812000},"page":"248-257","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":193,"title":["Conditional Deletion of <i>Smad1<\/i> and <i>Smad5<\/i> in Somatic Cells of Male and Female Gonads Leads to Metastatic Tumor Development in Mice"],"prefix":"10.1080","volume":"28","author":[{"given":"Stephanie A.","family":"Pangas","sequence":"first","affiliation":[{"name":"Departments of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieve","family":"Umans","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology (VIB7), Flanders Interuniversity Institute for Biotechnology (VIB), and Laboratory of Molecular Biology (CELGEN), Division of Molecular and Developmental Genetics, Department of Human Genetics (DME), Leuven-VIB, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Zwijsen","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology (VIB7), Flanders Interuniversity Institute for Biotechnology (VIB), and Laboratory of Molecular Biology (CELGEN), Division of Molecular and Developmental Genetics, Department of Human Genetics (DME), Leuven-VIB, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Huylebroeck","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology (VIB7), Flanders Interuniversity Institute for Biotechnology (VIB), and Laboratory of Molecular Biology (CELGEN), Division of Molecular and Developmental Genetics, Department of Human Genetics (DME), Leuven-VIB, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Departments of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Degang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Martin","sequence":"additional","affiliation":[{"name":"Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soazik P.","family":"Jamin","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Behringer","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin M.","family":"Matzuk","sequence":"additional","affiliation":[{"name":"Departments of Pathology"},{"name":"Molecular and Cellular Biology"},{"name":"Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ydbio.2006.04.442","volume":"296","author":"Arnold S. J.","year":"2006","journal-title":"Dev. Biol."},{"key":"R2","doi-asserted-by":"crossref","first-page":"G135","DOI":"10.1152\/ajpgi.00482.2005","volume":"291","author":"Beck S. E.","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"R3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/gut.45.3.406","volume":"45","author":"Bevan S.","year":"1999","journal-title":"Gut"},{"key":"R4","doi-asserted-by":"crossref","first-page":"9206","DOI":"10.1158\/0008-5472.CAN-05-1024","volume":"65","author":"Boerboom D.","year":"2005","journal-title":"Cancer Res."},{"key":"R5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/jcb.10679","volume":"91","author":"Brubaker K. D.","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"R6","first-page":"6996","volume":"61","author":"Buckhaults P.","year":"2001","journal-title":"Cancer Res."},{"key":"R7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/er.2002-0003","volume":"23","author":"Chang H.","year":"2002","journal-title":"Endocr. Rev."},{"key":"R8","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1242\/dev.126.8.1631","volume":"126","author":"Chang H.","year":"1999","journal-title":"Development"},{"key":"R9","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1158\/0008-5472.CAN-03-2688","volume":"64","author":"Cheng K. H.","year":"2004","journal-title":"Cancer Res."},{"key":"R10","first-page":"534","volume":"10","author":"Coerver K. A.","year":"1996","journal-title":"Mol. Endocrinol."},{"key":"R11","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1182\/blood-2006-07-034124","volume":"109","author":"David L.","year":"2007","journal-title":"Blood"},{"key":"R12","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","volume":"4","author":"Dennis G.","year":"2003","journal-title":"Genome Biol."},{"key":"R13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ng1001-117","volume":"29","author":"Derynck R.","year":"2001","journal-title":"Nat. Genet."},{"key":"R14","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1210\/endo.140.12.7204","volume":"140","author":"Durlinger A. L.","year":"1999","journal-title":"Endocrinology"},{"key":"R15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev.cellbio.21.022404.142018","volume":"21","author":"Feng X. H.","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"R16","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/sj.onc.1201614","volume":"16","author":"Gemma A.","year":"1998","journal-title":"Oncogene"},{"key":"R17","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/emboj\/21.7.1743","volume":"21","author":"Goumans M. J.","year":"2002","journal-title":"EMBO J."},{"key":"R18","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/ng1430","volume":"36","author":"He X. C.","year":"2004","journal-title":"Nat. Genet."},{"key":"R19","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/pros.10361","volume":"59","author":"Horvath L. G.","year":"2004","journal-title":"Prostate"},{"key":"R20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/88919","volume":"28","author":"Howe J. R.","year":"2001","journal-title":"Nat. Genet."},{"key":"R21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/gene.10059","volume":"32","author":"Huang S.","year":"2002","journal-title":"Genesis"},{"key":"R22","first-page":"7","volume":"7","author":"Jamin S. P.","year":"2002","journal-title":"Nat. Genet."},{"key":"R23","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1136\/gut.25.7.792","volume":"25","author":"Jarvinen H.","year":"1984","journal-title":"Gut"},{"key":"R24","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1210\/me.2003-0404","volume":"18","author":"Jeyasuria P.","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"R25","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1210\/me.2003-0301","volume":"18","author":"Jorgez C. J.","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"R26","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1128\/MCB.24.10.4241-4254.2004","volume":"24","author":"Kowanetz M.","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"R27","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1210\/me.2007-0147","volume":"21","author":"Li Q.","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"R28","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1210\/me.2006-0402","volume":"21","author":"Looyenga B. D.","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"R29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)00121-5","volume":"103","author":"Massague J.","year":"2000","journal-title":"Cell"},{"key":"R30","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1101\/gad.1350705","volume":"19","author":"Massague J.","year":"2005","journal-title":"Genes Dev."},{"key":"R31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/360313a0","volume":"360","author":"Matzuk M.","year":"1992","journal-title":"Nature"},{"key":"R32","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature03799","volume":"436","author":"Minn A. J.","year":"2005","journal-title":"Nature"},{"key":"R33","doi-asserted-by":"crossref","first-page":"9326","DOI":"10.1038\/sj.onc.1208127","volume":"23","author":"Miyazaki H.","year":"2004","journal-title":"Oncogene"},{"key":"R34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cytogfr.2005.01.009","volume":"16","author":"Miyazono K.","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"R35","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrc1611","volume":"5","author":"Naora H.","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"R36","doi-asserted-by":"crossref","first-page":"32281","DOI":"10.1074\/jbc.M403212200","volume":"279","author":"Pangas S. A.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"R37","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1210\/me.2007-0146","volume":"21","author":"Pangas S. A.","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"R38","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1210\/me.2005-0462","volume":"20","author":"Pangas S. A.","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"R39","author":"Pangas S. A.","year":"2007","journal-title":"The TGFB family."},{"key":"R40","first-page":"21","volume":"1775","author":"Pardali K.","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"R41","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nature05349","volume":"444","author":"Piccirillo S.","year":"2006","journal-title":"Nature"},{"key":"R42","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1677\/joe.0.1720187","volume":"172","author":"Pouliot F.","year":"2002","journal-title":"J. Endocrinol."},{"key":"R43","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1073\/pnas.92.5.1322","volume":"92","author":"Risma K.","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"R44","doi-asserted-by":"crossref","first-page":"8621","DOI":"10.1073\/pnas.1633291100","volume":"100","author":"Roberts A. B.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"R45","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/1097-0142(19891001)64:7<1508::AID-CNCR2820640725>3.0.CO;2-V","volume":"64","author":"Rose P. G.","year":"1989","journal-title":"Cancer"},{"key":"R46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0925-4439(02)00052-2","volume":"1588","author":"Schneider D.","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"R47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.febslet.2004.08.013","volume":"574","author":"Sgarra R.","year":"2004","journal-title":"FEBS Lett."},{"key":"R48","first-page":"3045","volume":"4","author":"Shim C.","year":"1998","journal-title":"Clin. Cancer Res."},{"key":"R49","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1182\/blood-2006-02-003384","volume":"108","author":"Singbrant S.","year":"2006","journal-title":"Blood"},{"key":"R50","doi-asserted-by":"crossref","first-page":"14842","DOI":"10.1073\/pnas.0606857103","volume":"103","author":"Sneddon J. B.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"R51","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm1469","volume":"12","author":"Steeg P. S.","year":"2006","journal-title":"Nat. Med."},{"key":"R52","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"Subramanian A.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"R53","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1242\/dev.128.18.3609","volume":"128","author":"Tremblay K. D.","year":"2001","journal-title":"Development"},{"key":"R54","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/gene.10219","volume":"37","author":"Umans L.","year":"2003","journal-title":"Genesis"},{"key":"R55","doi-asserted-by":"crossref","first-page":"7453","DOI":"10.1158\/0008-5472.CAN-06-0931","volume":"66","author":"Zaidi M. R.","year":"2006","journal-title":"Cancer Res."},{"key":"R56","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","volume":"9","author":"Zeisberg M.","year":"2003","journal-title":"Nat. Med."},{"key":"R57","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1242\/dev.02383","volume":"133","author":"Zhan Y.","year":"2006","journal-title":"Development"}],"container-title":["Molecular and Cellular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/MCB.01404-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1128\/MCB.01404-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T14:57:23Z","timestamp":1679929043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1128\/MCB.01404-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1,1]]}},"alternative-id":["10.1128\/MCB.01404-07"],"URL":"https:\/\/doi.org\/10.1128\/mcb.01404-07","relation":{},"ISSN":["1098-5549"],"issn-type":[{"value":"1098-5549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,1]]},"assertion":[{"value":"2007-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}