{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:07:41Z","timestamp":1790647661796,"version":"4.1.0"},"reference-count":59,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Mol Cell Biol"],"published-print":{"date-parts":[[1999,2]]},"DOI":"10.1128\/mcb.19.2.1289","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T06:17:32Z","timestamp":1445840252000},"page":"1289-1300","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":61,"title":["Protective Function of von Hippel-Lindau Protein against Impaired Protein Processing in Renal Carcinoma Cells"],"prefix":"10.1080","volume":"19","author":[{"given":"Myriam","family":"Gorospe","sequence":"first","affiliation":[{"name":"Laboratory of Biological Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine M.","family":"Egan","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Physiology, National Institute on Aging, National Institutes of Health","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berton","family":"Zbar","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lerman","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Geil","sequence":"additional","affiliation":[{"name":"Intramural Research Support Program, SAIC-Frederick, National Cancer Institute, National Institutes of Health","place":["Frederick"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Kuzmin","sequence":"additional","affiliation":[{"name":"Intramural Research Support Program, SAIC-Frederick, National Cancer Institute, National Institutes of Health","place":["Frederick"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki J.","family":"Holbrook","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00940.x"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80929-0"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1989.tb14609.x"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.8.4736-4744.1993"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.7.1991"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90035-6"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7660122"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80404-3"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81255-6"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(89)90279-6"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.16.7172"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(95)00012-5"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10589"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.17.9102"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2849206"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.3.762"},{"key":"e_1_3_2_18_1","first-page":"475","article-title":"Role of p21 in prostaglandin A2-mediated cellular arrest and death","volume":"56","author":"Gorospe M.","year":"1996","unstructured":"Gorospe, M., and J. Holbrook 1996. Role of p21 in prostaglandin A2-mediated cellular arrest and death. Cancer Res. 56:475\u2013479.","journal-title":"Cancer Res."},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930280320"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00812.x"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-6343-3_2"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0895-822"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10595"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401807"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(96)00697-5"},{"key":"e_1_3_2_26_1","first-page":"5328","article-title":"V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression","volume":"57","author":"Jiang B. H.","year":"1997","unstructured":"Jiang, B. H., F. Agani, A. Passaniti, and J. Semenza 1997. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res. 57:5328\u20135335.","journal-title":"Cancer Res."},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7660130"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.1.17"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81267-2"},{"key":"e_1_3_2_30_1","first-page":"4544","article-title":"Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations","volume":"55","author":"Kishida T.","year":"1995","unstructured":"Kishida, T., T. M. Stackhouse, F. Chen, M. I. Lerman, and J. Zbar 1995. Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations. Cancer Res. 55:4544\u20134548.","journal-title":"Cancer Res."},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.4.879.879"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.5.1770"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(87)90011-9"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.41.25492"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.82"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.2.368"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.2.732"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90719-7"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199711000-00001"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/386403a0"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.15.8104"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.24.12926"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.9.5629"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/353071a0"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2156"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.5.692"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.13.9367341"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30104-7"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00172-2"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.173.355"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.768"},{"key":"e_1_3_2_52_1","first-page":"2299","article-title":"Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein","volume":"56","author":"Siemeister G.","year":"1996","unstructured":"Siemeister, G., K. Weindel, K. Mohrs, B. Barleon, G. Martiny-Baron, and J. Marme 1996. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res. 56:2299\u20132301.","journal-title":"Cancer Res."},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.14.9409541"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.10.5363"},{"key":"e_1_3_2_55_1","first-page":"4233","article-title":"Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis","volume":"54","author":"Takahashi A.","year":"1994","unstructured":"Takahashi, A., H. Sasaki, S. J. Kim, K. Tobisu, T. Kakizoe, T. Tsukamoto, Y. Kumamoto, T. Sugimura, and J. Terada 1994. Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res. 54:4233\u20134237.","journal-title":"Cancer Res."},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(87)90258-7"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02222186"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360301105"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.8.1.393-405.1988"},{"key":"e_1_3_2_60_1","first-page":"1358","article-title":"Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas","volume":"55","author":"Wizigmann-Voos S.","year":"1995","unstructured":"Wizigmann-Voos, S., G. Breier, W. Risau, and J. Plate 1995. Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res. 55:1358\u20131364.","journal-title":"Cancer Res."}],"container-title":["Molecular and Cellular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/MCB.19.2.1289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1128\/MCB.19.2.1289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T19:21:33Z","timestamp":1770924093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1128\/MCB.19.2.1289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["10.1128\/MCB.19.2.1289"],"URL":"https:\/\/doi.org\/10.1128\/mcb.19.2.1289","relation":{},"ISSN":["1098-5549"],"issn-type":[{"value":"1098-5549","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2]]},"assertion":[{"value":"1998-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}