{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:41:07Z","timestamp":1792543267271,"version":"4.5.0"},"reference-count":30,"publisher":"Informa UK Limited","issue":"4","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Biology"],"published-print":{"date-parts":[[2001,2,1]]},"DOI":"10.1128\/mcb.21.4.1058-1065.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:03:53Z","timestamp":1027764233000},"page":"1058-1065","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":146,"title":["Targeted Disruption of the Methionine Synthase Gene in Mice"],"prefix":"10.1080","volume":"21","author":[{"given":"Deborah A.","family":"Swanson","sequence":"first","affiliation":[{"name":"Genetics and Molecular Biology Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Lan","family":"Liu","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, Bethesda, Maryland 20892; Department of Nutritional Sciences and Toxicology, University of California\u2014Berkeley, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla J.","family":"Baker","sequence":"additional","affiliation":[{"name":"Genetics and Molecular Biology Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Garrett","sequence":"additional","affiliation":[{"name":"Genetic Disease Research Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stitzel","sequence":"additional","affiliation":[{"name":"Genetics and Molecular Biology Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Nebraska\u2014Lincoln, Lincoln, Nebraska 68588"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Harris","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, Bethesda, Maryland 20892; Department of Nutritional Sciences and Toxicology, University of California\u2014Berkeley, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruma","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Nebraska\u2014Lincoln, Lincoln, Nebraska 68588"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Shane","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, Bethesda, Maryland 20892; Department of Nutritional Sciences and Toxicology, University of California\u2014Berkeley, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence C.","family":"Brody","sequence":"additional","affiliation":[{"name":"Genetics and Molecular Biology Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.7.14.7901104"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(87)80438-3"},{"key":"B3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0076-6879(97)81025-7","volume":"281","author":"Banerjee R.","year":"1997","journal-title":"Methods Enzymol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.6.3628"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.40.26248"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1021\/bi9705164"},{"key":"B8","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1093\/hmg\/5.12.1859","volume":"5","author":"Gulati S.","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"B9","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/0002-9378(68)90406-7","volume":"102","author":"Hayashi T. T.","year":"1968","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.12.1442"},{"key":"B11","first-page":"703","volume":"86","author":"Kirke P. N.","year":"1993","journal-title":"Q. J. Med."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6275.1509"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.12.1867"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3059"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.12.1851"},{"key":"B16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2527\/1993.711151x","volume":"71","author":"Matte J. J.","year":"1993","journal-title":"J. Anim. Sci."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90165-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90133-A"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/13861"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.49.1.31"},{"key":"B21","volume-title":"The mouse: its reproduction and development.","author":"Rugh R.","year":"1990"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.05.070185.000555"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.12.944"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92654-5"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90474-3"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(94)90004-3"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.39.25179"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90011-M"},{"key":"B29","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/jn\/118.9.1089","volume":"118","author":"Walzem R. L.","year":"1988","journal-title":"J. Nutr."},{"key":"B30","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1086\/301976","volume":"63","author":"Wilson A.","year":"1998","journal-title":"Am. J. Hum. Genet."}],"container-title":["Molecular and Cellular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/MCB.21.4.1058-1065.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1128\/MCB.21.4.1058-1065.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T13:30:24Z","timestamp":1680010224000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1128\/MCB.21.4.1058-1065.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,1]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,2,1]]}},"alternative-id":["10.1128\/MCB.21.4.1058-1065.2001"],"URL":"https:\/\/doi.org\/10.1128\/mcb.21.4.1058-1065.2001","relation":{},"ISSN":["1098-5549"],"issn-type":[{"value":"1098-5549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2,1]]},"assertion":[{"value":"2000-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}