{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:08:27Z","timestamp":1787314107559,"version":"build-2736575974"},"reference-count":43,"publisher":"Informa UK Limited","issue":"6","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Mol Cell Biol"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1128\/mcb.22.6.1704-1713.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:56:57Z","timestamp":1027749417000},"page":"1704-1713","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":84,"title":["The Endothelial Receptor Tyrosine Kinase Tie1 Activates Phosphatidylinositol 3-Kinase and Akt To Inhibit Apoptosis"],"prefix":"10.1080","volume":"22","author":[{"given":"Christopher D.","family":"Kontos","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology"},{"name":"Department of Pharmacology and Cancer Biology, Duke University Medical Center","place":["Durham"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene H.","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"York","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Cancer Biology, Duke University Medical Center","place":["Durham"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Peters","sequence":"additional","affiliation":[{"name":"Procter & Gamble Health Care Research Center","place":["Mason"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(96)80060-3"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81812-7"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.9.7.2890-2896.1989"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80149-X"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(91)90265-V"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030109"},{"key":"e_1_3_2_8_1","first-page":"1293","article-title":"The endothelial-specific receptor tyrosine kinase, TEK, is a member of a new subfamily of receptors.","volume":"8","author":"Dumont D. J.","year":"1993","unstructured":"Dumont, D. J., G. J. Gradwohl, G. H. Fong, R. Auerbach, and M. L. Breitman. 1993. The endothelial-specific receptor tyrosine kinase, TEK, is a member of a new subfamily of receptors. Oncogene 8: 1293\u20131302.","journal-title":"Oncogene"},{"key":"e_1_3_2_9_1","first-page":"1471","article-title":"tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.","volume":"7","author":"Dumont D. J.","year":"1992","unstructured":"Dumont, D. J., T. P. Yamaguchi, R. A. Conlon, J. Rossant, and M. L. Breitman. 1992. tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene 7: 1471\u20131480.","journal-title":"Oncogene"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/70928"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80108-7"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003920050477"},{"key":"e_1_3_2_13_1","first-page":"2097","article-title":"GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK receptor tyrosine kinase.","volume":"11","author":"Huang L.","year":"1995","unstructured":"Huang, L., C. W. Turck, P. Rao, and K. G. Peters. 1995. GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK receptor tyrosine kinase. Oncogene 11: 2097\u20132103.","journal-title":"Oncogene"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.43.30896"},{"key":"e_1_3_2_15_1","first-page":"6571","article-title":"Enhanced expression of the tie receptor tyrosine kinase messenger RNA in the vascular endothelium of metastatic melanomas.","volume":"54","author":"Kaipainen A.","year":"1994","unstructured":"Kaipainen, A., T. Vlaykova, E. Hatva, T. Bohling, A. Jekunen, S. Pyrhonen, and K. Alitalo. 1994. Enhanced expression of the tie receptor tyrosine kinase messenger RNA in the vascular endothelium of metastatic melanomas. Cancer Res. 54: 6571\u20136577.","journal-title":"Cancer Res."},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.9.952"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.1.24"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.38.22208"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70205-2"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.7.4131"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.10.2548.2548"},{"key":"e_1_3_2_22_1","first-page":"395","article-title":"The mouse tie receptor tyrosine kinase gene: expression during embryonic development.","volume":"9","author":"Korhonen J.","year":"1994","unstructured":"Korhonen, J., A. Polvi, J. Partanen, and K. Alitalo. 1994. The mouse tie receptor tyrosine kinase gene: expression during embryonic development. Oncogene 9: 395\u2013403.","journal-title":"Oncogene"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.3.1595"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00171-X"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5322.55"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007189200"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4221-6_3"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.13.9102"},{"key":"e_1_3_2_29_1","first-page":"213","article-title":"Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.","volume":"79","author":"Papapetropoulos A.","year":"1999","unstructured":"Papapetropoulos, A., G. Garcia-Cardena, T. J. Dengler, P. C. Maisonpierre, G. D. Yancopoulos, and W. C. Sessa. 1999. Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. Lab. Investig. 79: 213\u2013223.","journal-title":"Lab. Investig."},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.12.4.1698-1707.1992"},{"key":"e_1_3_2_31_1","first-page":"159","article-title":"Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development.","volume":"237","author":"Partanen J.","year":"1999","unstructured":"Partanen, J., and D. J. Dumont. 1999. Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development. Curr. Top. Microbiol. Immunol. 237: 159\u2013172.","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.10.3013"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.20.4569"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb00276.x"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.13.8347"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.20.9355"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/376070a0"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00114-8"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90404-E"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.1904"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.29.18514"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.6.1969.406k14_1969_1979"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.2.706"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/35025215"}],"container-title":["Molecular and Cellular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/MCB.22.6.1704-1713.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1128\/MCB.22.6.1704-1713.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T19:04:15Z","timestamp":1770404655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1128\/MCB.22.6.1704-1713.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1128\/MCB.22.6.1704-1713.2002"],"URL":"https:\/\/doi.org\/10.1128\/mcb.22.6.1704-1713.2002","relation":{},"ISSN":["1098-5549"],"issn-type":[{"value":"1098-5549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]},"assertion":[{"value":"2001-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-12-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}