{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:55:29Z","timestamp":1793332529866,"version":"4.5.0"},"reference-count":195,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Members of the highly heterogeneous family\n                    <jats:italic>Pasteurellaceae<\/jats:italic>\n                    cause a wide variety of diseases in humans and animals. Antimicrobial agents are the most powerful tools to control such infections. However, the acquisition of resistance genes, as well as the development of resistance-mediating mutations, significantly reduces the efficacy of the antimicrobial agents. This article gives a brief description of the role of selected members of the family\n                    <jats:italic>Pasteurellaceae<\/jats:italic>\n                    in animal infections and of the most recent data on the susceptibility status of such members. Moreover, a review of the current knowledge of the genetic basis of resistance to antimicrobial agents is included, with particular reference to resistance to tetracyclines, \u03b2-lactam antibiotics, aminoglycosides\/aminocyclitols, folate pathway inhibitors, macrolides, lincosamides, phenicols, and quinolones. This article focusses on the genera of veterinary importance for which sufficient data on antimicrobial susceptibility and the detection of resistance genes are currently available (\n                    <jats:italic>Pasteurella<\/jats:italic>\n                    ,\n                    <jats:italic>Mannheimia<\/jats:italic>\n                    ,\n                    <jats:italic>Actinobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Haemophilus<\/jats:italic>\n                    , and\n                    <jats:italic>Histophilus<\/jats:italic>\n                    ). Additionally, the role of plasmids, transposons, and integrative and conjugative elements in the spread of the resistance genes within and beyond the aforementioned genera is highlighted to provide insight into horizontal dissemination, coselection, and persistence of antimicrobial resistance genes. The article discusses the acquisition of diverse resistance genes by the selected\n                    <jats:italic>Pasteurellaceae<\/jats:italic>\n                    members from other Gram-negative or maybe even Gram-positive bacteria. Although the susceptibility status of these members still looks rather favorable, monitoring of their antimicrobial susceptibility is required for early detection of changes in the susceptibility status and the newly acquired\/developed resistance mechanisms.\n                  <\/jats:p>","DOI":"10.1128\/microbiolspec.arba-0022-2017","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T08:45:13Z","timestamp":1529397913000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":74,"title":["Antimicrobial Resistance in\n                    <i>Pasteurellaceae<\/i>\n                    of Veterinary Origin"],"prefix":"10.1128","volume":"6","author":[{"given":"Geovana B.","family":"Michael","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Epizootics, Freie Universit\u00e4t Berlin, Berlin, D-14163 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine T.","family":"Boss\u00e9","sequence":"additional","affiliation":[{"name":"Section of Pediatrics, Department of Medicine London, Imperial College London, London W2 1PG, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epizootics, Freie Universit\u00e4t Berlin, Berlin, D-14163 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Christensen H Kuhnert P Busse HJ Frederiksen WC Bisgaard M. 2007. 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Rodentibacter rarus sp. nov. Rodentibacter mrazii and two genomospecies. Int J Syst Evol Microbiol 67: 1793\u20131806 http:\/\/dx.doi.org\/10.1099\/ijsem.0.001866.","DOI":"10.1099\/ijsem.0.001866"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Christensen H Kuhnert P Bisgaard M Mutters R Dziva F Olsen JE. 2005. Emended description of porcine [ Pasteurella ] aerogenes [ Pasteurella ] mairii and [ Actinobacillus ] rossii . Int J Syst Evol Microbiol 55: 209\u2013223 http:\/\/dx.doi.org\/10.1099\/ijs.0.63119-0. [PubMed]","DOI":"10.1099\/ijs.0.63119-0"},{"key":"e_1_3_2_6_2","unstructured":"Christensen H Bisgaard M. 2008. Taxonomy and biodiversity of members of Pasteurellaceae p 1\u201325. In Kuhnert P Christensen H (ed) Pasteurellaceae: Biology Genomics and Molecular Aspects . Caister Academic Press Norfolk United Kingdom."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Bonaventura MP Lee EK Desalle R Planet PJ. 2010. A whole-genome phylogeny of the family Pasteurellaceae . Mol Phylogenet Evol 54: 950\u2013956 http:\/\/dx.doi.org\/10.1016\/j.ympev.2009.08.010. [PubMed]","DOI":"10.1016\/j.ympev.2009.08.010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","unstructured":"Moustafa AM Seemann T Gladman S Adler B Harper M Boyce JD Bennett MD. 2015. Comparative genomic analysis of Asian haemorrhagic septicaemia-associated strains of Pasteurella multocida identifies more than 90 haemorrhagic septicaemia-specific genes. PLoS One 10: e0130296 http:\/\/dx.doi.org\/10.1371\/journal.pone.0130296. [PubMed]","DOI":"10.1371\/journal.pone.0130296"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Clawson ML Murray RW Sweeney MT Apley MD DeDonder KD Capik SF Larson RL Lubbers BV White BJ Kalbfleisch TS Schuller G Dickey AM Harhay GP Heaton MP Chitko-McKown CG Brichta-Harhay DM Bono JL Smith TP. 2016. Genomic signatures of Mannheimia haemolytica that associate with the lungs of cattle with respiratory disease an integrative conjugative element and antibiotic resistance genes. BMC Genomics 17: 982 http:\/\/dx.doi.org\/10.1186\/s12864-016-3316-8. [PubMed]","DOI":"10.1186\/s12864-016-3316-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"Boss\u00e9 JT Li Y Rogers J Fernandez Crespo R Li Y Chaudhuri RR Holden MT Maskell DJ Tucker AW Wren BW Rycroft AN Langford PR. 2017. Whole genome sequencing for surveillance of antimicrobial resistance in Actinobacillus pleuropneumoniae . Front Microbiol 8: 311 http:\/\/dx.doi.org\/10.3389\/fmicb.2017.00311. [PubMed]","DOI":"10.3389\/fmicb.2017.00311"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"Kehrenberg C Walker RD Wu CC Schwarz S. 2006. Antimicrobial resistance in members of the family Pasteurellaceae p 167\u2013186. In Aarestrup FM (ed) Antimicrobial Resistance in Bacteria of Animal Origin . 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