{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:03:47Z","timestamp":1792029827149,"version":"4.4.0"},"reference-count":173,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2017,5,19]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bifidobacteria are members of the intestinal microbiota of mammals and other animals, and some strains are able to exert health-promoting effects. The genus\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    belongs to the\n                    <jats:italic>Actinobacteria<\/jats:italic>\n                    phylum.\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    ,\n                    <jats:italic>Bacteroidetes<\/jats:italic>\n                    , and\n                    <jats:italic>Actinobacteria<\/jats:italic>\n                    constitute the most abundant phyla in the human intestinal microbiota,\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    and\n                    <jats:italic>Bacteroidetes<\/jats:italic>\n                    being predominant in adults, and\n                    <jats:italic>Actinobacteria<\/jats:italic>\n                    in breast-fed infants, where bifidobacteria can reach levels higher than 90% of the total bacterial population. They are among the first microbial colonizers of the intestines of newborns, and play key roles in the development of their physiology, including maturation of the immune system and use of dietary components. Indeed, some nutrients, such as human milk oligosaccharides, are important drivers of bifidobacterial development. Some\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    strains are considered probiotic microorganisms because of their beneficial effects, and they have been included as bioactive ingredients in functional foods, mainly dairy products, as well as in food supplements and pharma products, alone, or together with, other microbes or microbial substrates. Well-documented scientific evidence of their activities is currently available for bifidobacteria-containing preparations in some intestinal and extraintestinal pathologies. In this review, we focus on the role of bifidobacteria as members of the human intestinal microbiota and their use as probiotics in the prevention and treatment of disease.\n                  <\/jats:p>","DOI":"10.1128\/microbiolspec.bad-0010-2016","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T08:45:19Z","timestamp":1498207519000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":396,"title":["Bifidobacteria and Their Health-Promoting Effects"],"prefix":"10.1128","volume":"5","author":[{"given":"Claudio","family":"Hidalgo-Cantabrana","sequence":"first","affiliation":[{"name":"Department of Microbiology and Biochemistry of Dairy Products, Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Paseo R\u00edo Linares s\/n 33300, Villaviciosa, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry of Dairy Products, Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Paseo R\u00edo Linares s\/n 33300, Villaviciosa, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry of Dairy Products, Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Paseo R\u00edo Linares s\/n 33300, Villaviciosa, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ruas-Madiedo","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry of Dairy Products, Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Paseo R\u00edo Linares s\/n 33300, Villaviciosa, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry of Dairy Products, Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Paseo R\u00edo Linares s\/n 33300, Villaviciosa, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abelardo","family":"Margolles","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry of Dairy Products, Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Paseo R\u00edo Linares s\/n 33300, Villaviciosa, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Rodr\u00edguez I Gaspar P S\u00e1nchez B Gueimonde M Margolles A Neves AR. 2013. 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