{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:42:02Z","timestamp":1794350522583,"version":"4.9.0"},"reference-count":133,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2019,4,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:italic>Wolbachia<\/jats:italic>\n            endosymbionts encompass a large group of intracellular bacteria of biomedical and veterinary relevance, closely related to\n            <jats:italic>Anaplasma<\/jats:italic>\n            ,\n            <jats:italic>Ehrlichia<\/jats:italic>\n            , and\n            <jats:italic>Rickettsia<\/jats:italic>\n            . This genus of Gram-negative members of the\n            <jats:italic>Alphaproteobacteria<\/jats:italic>\n            does not infect vertebrates but is instead restricted to ecdysozoan species, including terrestrial arthropods and a family of parasitic filarial nematodes, the Onchocercidae. The\n            <jats:italic>Wolbachia<\/jats:italic>\n            profoundly impact not only the ecology and evolution but also the reproductive biology of their hosts, through a wide range of symbiotic interactions. Because they are essential to the survival and reproduction of their filarial nematode hosts, they represent an attractive target to fight filariasis. Their abilities to spread through insect populations and to affect vector competence through pathogen protection have made\n            <jats:italic>Wolbachia<\/jats:italic>\n            a staple for controlling vector-borne diseases. Estimated to be present in up to 66% of insect species, the\n            <jats:italic>Wolbachia<\/jats:italic>\n            are probably the most abundant endosymbionts on earth. Their success resides in their unique capacity to infect and manipulate the host germ line to favor their vertical transmission through the maternal lineage. Because the\n            <jats:italic>Wolbachia<\/jats:italic>\n            resist genetic manipulation and growth in axenic culture, our understanding of their biology is still in its infancy. Despite these limitations, the \u201c-omics\u201d revolution combined with the use of well-established and emerging experimental host models is accelerating our comprehension of the host phenotypes caused by\n            <jats:italic>Wolbachia<\/jats:italic>\n            , and the identification of\n            <jats:italic>Wolbachia<\/jats:italic>\n            effectors is ongoing.\n          <\/jats:p>","DOI":"10.1128\/microbiolspec.bai-0018-2019","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T12:30:17Z","timestamp":1554553817000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":141,"title":["The\n            <i>Wolbachia<\/i>\n            Endosymbionts"],"prefix":"10.1128","volume":"7","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Landmann","sequence":"first","affiliation":[{"name":"CRBM, University of Montpellier, CNRS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Hilgenboecker K Hammerstein P Schlattmann P Telschow A Werren JH. 2008. How many species are infected with Wolbachia ? A statistical analysis of current data. FEMS Microbiol Lett 281: 215\u2013220 http:\/\/dx.doi.org\/10.1111\/j.1574-6968.2008.01110.x.","DOI":"10.1111\/j.1574-6968.2008.01110.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Slatko BE Luck AN Dobson SL Foster JM. 2014. Wolbachia endosymbionts and human disease control. Mol Biochem Parasitol 195: 88\u201395 http:\/\/dx.doi.org\/10.1016\/j.molbiopara.2014.07.004.","DOI":"10.1016\/j.molbiopara.2014.07.004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Werren JH Baldo L Clark ME. 2008. Wolbachia : master manipulators of invertebrate biology. Nat Rev Microbiol 6: 741\u2013751 http:\/\/dx.doi.org\/10.1038\/nrmicro1969.","DOI":"10.1038\/nrmicro1969"},{"key":"e_1_3_2_5_2","unstructured":"Hertig M Wolbach SB. 1924. Studies on Rickettsia -like micro-organisms in insects. J Med Res 44: 329\u2013374.7."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Baldo L Dunning Hotopp JC Jolley KA Bordenstein SR Biber SA Choudhury RR Hayashi C Maiden MCJ Tettelin H Werren JH. 2006.Multilocus sequence typing system for the endosymbiont Wolbachia pipientis . Appl Environ Microbiol 72: 7098\u20137110 http:\/\/dx.doi.org\/10.1128\/AEM.00731-06.","DOI":"10.1128\/AEM.00731-06"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Bandi C Anderson TJC Genchi C Blaxter ML. 1998. Phylogeny of Wolbachia in filarial nematodes. Proc Biol Sci 265: 2407\u20132413 http:\/\/dx.doi.org\/10.1098\/rspb.1998.0591. [PubMed]","DOI":"10.1098\/rspb.1998.0591"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","unstructured":"Kozek WJ. 1977. Transovarially-transmitted intracellular microorganisms in adult and larval stages of Brugia malayi . J Parasitol 63: 992\u20131000 http:\/\/dx.doi.org\/10.2307\/3279832. [PubMed]","DOI":"10.2307\/3279832"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Lefoulon E Bain O Makepeace BL d\u2019Haese C Uni S Martin C Gavotte L. 2016. Breakdown of coevolution between symbiotic bacteria Wolbachia and their filarial hosts. PeerJ 4: e1840 http:\/\/dx.doi.org\/10.7717\/peerj.1840. [PubMed]","DOI":"10.7717\/peerj.1840"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"Glowska E Dragun-Damian A Dabert M Gerth M. 2015. New Wolbachia supergroups detected in quill mites (Acari: Syringophilidae). Infect Genet Evol 30: 140\u2013146 http:\/\/dx.doi.org\/10.1016\/j.meegid.2014.12.019. [PubMed]","DOI":"10.1016\/j.meegid.2014.12.019"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"Wang G-H Jia L-Y Xiao J-H Huang D-W. 2016. Discovery of a new Wolbachia supergroup in cave spider species and the lateral transfer of phage WO among distant hosts. Infect Genet Evol 41: 1\u20137 http:\/\/dx.doi.org\/10.1016\/j.meegid.2016.03.015. [PubMed]","DOI":"10.1016\/j.meegid.2016.03.015"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"Casiraghi M Anderson TJC Bandi C Bazzocchi C Genchi C. 2001. A phylogenetic analysis of filarial nematodes: comparison with the phylogeny of Wolbachia endosymbionts. Parasitology 122: 93\u2013103 http:\/\/dx.doi.org\/10.1017\/S0031182000007149. [PubMed]","DOI":"10.1017\/S0031182000007149"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","unstructured":"Lo N Casiraghi M Salati E Bazzocchi C Bandi C. 2002. How many Wolbachia supergroups exist? Mol Biol Evol 19: 341\u2013346 http:\/\/dx.doi.org\/10.1093\/oxfordjournals.molbev.a004087. [PubMed]","DOI":"10.1093\/oxfordjournals.molbev.a004087"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"Haegeman A Vanholme B Jacob J Vandekerckhove TTM Claeys M Borgonie G Gheysen G. 2009. An endosymbiotic bacterium in a plant-parasitic nematode: member of a new Wolbachia supergroup. Int J Parasitol 39: 1045\u20131054 http:\/\/dx.doi.org\/10.1016\/j.ijpara.2009.01.006. [PubMed]","DOI":"10.1016\/j.ijpara.2009.01.006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","unstructured":"Brown AMV Wasala SK Howe DK Peetz AB Zasada IA Denver DR. 2016. Genomic evidence for plant-parasitic nematodes as the earliest Wolbachia hosts. Sci Rep 6: 34955 http:\/\/dx.doi.org\/10.1038\/srep34955. [PubMed]","DOI":"10.1038\/srep34955"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","unstructured":"Foster J Ganatra M Kamal I Ware J Makarova K Ivanova N Bhattacharyya A Kapatral V Kumar S Posfai J Vincze T Ingram J Moran L Lapidus A Omelchenko M Kyrpides N Ghedin E Wang S Goltsman E Joukov V Ostrovskaya O Tsukerman K Mazur M Comb D Koonin E Slatko B. 2005. The Wolbachia genome of Brugia malayi : endosymbiont evolution within a human pathogenic nematode. PLoS Biol 3: e121 http:\/\/dx.doi.org\/10.1371\/journal.pbio.0030121. [PubMed]","DOI":"10.1371\/journal.pbio.0030121"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","unstructured":"Wu M Sun LV Vamathevan J Riegler M Deboy R Brownlie JC McGraw EA Martin W Esser C Ahmadinejad N Wiegand C Madupu R Beanan MJ Brinkac LM Daugherty SC Durkin AS Kolonay JF Nelson WC Mohamoud Y Lee P Berry K Young MB Utterback T Weidman J Nierman WC Paulsen IT Nelson KE Tettelin H O\u2019Neill SL Eisen JA. 2004. Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements. PLoS Biol 2: e69 http:\/\/dx.doi.org\/10.1371\/journal.pbio.0020069. [PubMed]","DOI":"10.1371\/journal.pbio.0020069"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"Masui S Kamoda S Sasaki T Ishikawa H. 2000. Distribution and evolution of bacteriophage WO in Wolbachia the endosymbiont causing sexual alterations in arthropods. J Mol Evol 51: 491\u2013497 http:\/\/dx.doi.org\/10.1007\/s002390010112. [PubMed]","DOI":"10.1007\/s002390010112"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","unstructured":"LePage DP Metcalf JA Bordenstein SR On J Perlmutter JI Shropshire JD Layton EM Funkhouser-Jones LJ Beckmann JF Bordenstein SR. 2017. Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature 543: 243\u2013247 http:\/\/dx.doi.org\/10.1038\/nature21391. [PubMed]","DOI":"10.1038\/nature21391"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","unstructured":"Pichon S Bouchon D Cordaux R Chen L Garrett RA Gr\u00e8ve P. 2009. Conservation of the type IV secretion system throughout Wolbachia evolution. Biochem Biophys Res Commun 385: 557\u2013562 http:\/\/dx.doi.org\/10.1016\/j.bbrc.2009.05.118. [PubMed]","DOI":"10.1016\/j.bbrc.2009.05.118"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","unstructured":"Li Z Carlow CKS. 2012. Characterization of transcription factors that regulate the type IV secretion system and riboflavin biosynthesis in Wolbachia of Brugia malayi . PLoS One 7: e51597 http:\/\/dx.doi.org\/10.1371\/journal.pone.0051597. [PubMed]","DOI":"10.1371\/journal.pone.0051597"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","unstructured":"Masui S Sasaki T Ishikawa H. 2000. Genes for the type IV secretion system in an intracellular symbiont Wolbachia a causative agent of various sexual alterations in arthropods. J Bacteriol 182: 6529\u20136531 http:\/\/dx.doi.org\/10.1128\/JB.182.22.6529-6531.2000. [PubMed]","DOI":"10.1128\/JB.182.22.6529-6531.2000"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","unstructured":"Ranc\u00e8s E Voronin D Tran-Van V Mavingui P. 2008. Genetic and functional characterization of the type IV secretion system in Wolbachia . J Bacteriol 190: 5020\u20135030 http:\/\/dx.doi.org\/10.1128\/JB.00377-08. [PubMed]","DOI":"10.1128\/JB.00377-08"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","unstructured":"F\u00e9lix C Pichon S Braquart-Varnier C Braig H Chen L Garrett RA Martin G Gr\u00e8ve P. 2008. Characterization and transcriptional analysis of two gene clusters for type IV secretion machinery in Wolbachia of Armadillidium vulgare . Res Microbiol 159: 481\u2013485 http:\/\/dx.doi.org\/10.1016\/j.resmic.2008.05.007. [PubMed]","DOI":"10.1016\/j.resmic.2008.05.007"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","unstructured":"Ote M Ueyama M Yamamoto D. 2016. Wolbachia protein TomO targets nanos mRNA and restores germ stem cells in Drosophila sex-lethal mutants. Curr Biol 26: 2223\u20132232 http:\/\/dx.doi.org\/10.1016\/j.cub.2016.06.054. [PubMed]","DOI":"10.1016\/j.cub.2016.06.054"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","unstructured":"Sheehan KB Martin M Lesser CF Isberg RR Newton ILG. 2016. Identification and characterization of a candidate Wolbachia pipientis type IV effector that interacts with the actin cytoskeleton. mBio 7: e00622-16 http:\/\/dx.doi.org\/10.1128\/mBio.00622-16. [PubMed]","DOI":"10.1128\/mBio.00622-16"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","unstructured":"Beckmann JF Fallon AM. 2013. Detection of the Wolbachia protein WPIP0282 in mosquito spermathecae: implications for cytoplasmic incompatibility. Insect Biochem Mol Biol 43: 867\u2013878 http:\/\/dx.doi.org\/10.1016\/j.ibmb.2013.07.002. [PubMed]","DOI":"10.1016\/j.ibmb.2013.07.002"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","unstructured":"Beckmann JF Ronau JA Hochstrasser M. 2017. A Wolbachia deubiquitylating enzyme induces cytoplasmic incompatibility. Nat Microbiol 2: 17007 http:\/\/dx.doi.org\/10.1038\/nmicrobiol.2017.7. [PubMed]","DOI":"10.1038\/nmicrobiol.2017.7"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","unstructured":"Shropshire JD On J Layton EM Zhou H Bordenstein SR. 2018. One prophage WO gene rescues cytoplasmic incompatibility in Drosophila melanogaster . Proc Natl Acad Sci USA 115: 4987\u20134991 http:\/\/dx.doi.org\/10.1073\/pnas.1800650115. [PubMed]","DOI":"10.1073\/pnas.1800650115"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","unstructured":"Rice DW Sheehan KB Newton ILG. 2017. Large-scale identification of Wolbachia pipientis effectors. Genome Biol Evol 9: 1925\u20131937 http:\/\/dx.doi.org\/10.1093\/gbe\/evx139. [PubMed]","DOI":"10.1093\/gbe\/evx139"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","unstructured":"Carpinone EM Li Z Mills MK Foltz C Brannon ER Carlow CKS Starai VJ. 2018. Identification of putative effectors of the type IV secretion system from the Wolbachia endosymbiont of Brugia malayi . PLoS One 13: e0204736 http:\/\/dx.doi.org\/10.1371\/journal.pone.0204736. [PubMed]","DOI":"10.1371\/journal.pone.0204736"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","unstructured":"Pietri JE DeBruhl H Sullivan W. 2016. The rich somatic life of Wolbachia . MicrobiologyOpen 5: 923\u2013936 http:\/\/dx.doi.org\/10.1002\/mbo3.390. [PubMed]","DOI":"10.1002\/mbo3.390"},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","unstructured":"Rasgon JL Gamston CE Ren X. 2006. Survival of Wolbachia pipientis in cell-free medium. Appl Environ Microbiol 72: 6934\u20136937 http:\/\/dx.doi.org\/10.1128\/AEM.01673-06. [PubMed]","DOI":"10.1128\/AEM.01673-06"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","unstructured":"Serbus LR Casper-Lindley C Landmann F Sullivan W. 2008. The genetics and cell biology of Wolbachia -host interactions. Annu Rev Genet 42: 683\u2013707 http:\/\/dx.doi.org\/10.1146\/annurev.genet.41.110306.130354. [PubMed]","DOI":"10.1146\/annurev.genet.41.110306.130354"},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","unstructured":"Weeks AR Breeuwer JAJ. 2001. Wolbachia -induced parthenogenesis in a genus of phytophagous mites. Proc Biol Sci 268: 2245\u20132251 http:\/\/dx.doi.org\/10.1098\/rspb.2001.1797. [PubMed]","DOI":"10.1098\/rspb.2001.1797"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","unstructured":"Gottlieb Y Zchori-Fein E. 2001. Irreversible thelytokous reproduction in Muscidifurax uniraptor . Entomol Exp Appl 100: 271\u2013278 http:\/\/dx.doi.org\/10.1046\/j.1570-7458.2001.00874.x.","DOI":"10.1046\/j.1570-7458.2001.00874.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","unstructured":"Stouthamer R Kazmer DJ. 1994. Cytogenetics of microbe-associated parthenogenesis and its consequences for gene flow in Trichogramma wasps. Hered Edinb 73: 317\u2013327 http:\/\/dx.doi.org\/10.1038\/hdy.1994.139.","DOI":"10.1038\/hdy.1994.139"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","unstructured":"Adachi-Hagimori T Miura K Stouthamer R. 2008. A new cytogenetic mechanism for bacterial endosymbiont-induced parthenogenesis in Hymenoptera . Proc Biol Sci 275: 2667\u20132673 http:\/\/dx.doi.org\/10.1098\/rspb.2008.0792. [PubMed]","DOI":"10.1098\/rspb.2008.0792"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","unstructured":"Cordaux R Bouchon D Gr\u00e8ve P. 2011. The impact of endosymbionts on the evolution of host sex-determination mechanisms. Trends Genet 27: 332\u2013341 http:\/\/dx.doi.org\/10.1016\/j.tig.2011.05.002. [PubMed]","DOI":"10.1016\/j.tig.2011.05.002"},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","unstructured":"Bouchon D Cordaux R Gr\u00e8ve P. 2008. Feminizing Wolbachia and the evolution of sex determination in isopods p 273\u2013294. In Bourtzis K Miller T (ed) Insect Symbiosis vol 3. CRC Press Boca Raton FL.","DOI":"10.1201\/9781420064117.ch12"},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","unstructured":"Ferdy JB Liu N Sicard M. 2016. Transmission modes and the evolution of feminizing symbionts. J Evol Biol 29: 2395\u20132409 http:\/\/dx.doi.org\/10.1111\/jeb.12963. [PubMed]","DOI":"10.1111\/jeb.12963"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","unstructured":"Hurst GDD Majerus MEN. 1993. Why do maternally inherited microorganisms kill males? Hered Edinb 71: 81\u201395 http:\/\/dx.doi.org\/10.1038\/hdy.1993.110.","DOI":"10.1038\/hdy.1993.110"},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","unstructured":"Hurst GDD Jiggins FM Majerus MEN. 2003. Inherited microorganisms that selectively kill male hosts: the hidden players of insect evolution? p 177\u2013199. In Bourtzis K Miller T (ed) Insect Symbiosis vol 1. CRC Press Boca Raton FL.","DOI":"10.1201\/9780203009918.ch12"},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","unstructured":"Riparbelli MG Giordano R Ueyama M Callaini G. 2012. Wolbachia -mediated male killing is associated with defective chromatin remodeling. PLoS One 7: e30045 http:\/\/dx.doi.org\/10.1371\/journal.pone.0030045. [PubMed]","DOI":"10.1371\/journal.pone.0030045"},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","unstructured":"Harumoto T Lemaitre B. 2018. Male-killing toxin in a bacterial symbiont of Drosophila . Nature 557: 252\u2013255 http:\/\/dx.doi.org\/10.1038\/s41586-018-0086-2. [PubMed]","DOI":"10.1038\/s41586-018-0086-2"},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","unstructured":"Veneti Z. 2005. A functional dosage compensation complex required for male killing in Drosophila . Science 307: 1461\u20131463. [PubMed]","DOI":"10.1126\/science.1107182"},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","unstructured":"Bordenstein SR Werren JH. 2007. Bidirectional incompatibility among divergent Wolbachia and incompatibility level differences among closely related Wolbachia in Nasonia . Hered Edinb 99: 278\u2013287 http:\/\/dx.doi.org\/10.1038\/sj.hdy.6800994. [PubMed]","DOI":"10.1038\/sj.hdy.6800994"},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","unstructured":"Yen JH Barr AR. 1971. New hypothesis of the cause of cytoplasmic incompatibility in Culex pipiens L. Nature 232: 657\u2013658 http:\/\/dx.doi.org\/10.1038\/232657a0. [PubMed]","DOI":"10.1038\/232657a0"},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","unstructured":"Clark ME Veneti Z Bourtzis K Karr TL. 2002. The distribution and proliferation of the intracellular bacteria Wolbachia during spermatogenesis in Drosophila . Mech Dev 111: 3\u201315 http:\/\/dx.doi.org\/10.1016\/S0925-4773(01)00594-9.","DOI":"10.1016\/S0925-4773(01)00594-9"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","unstructured":"Callaini G Dallai R Riparbelli MG. 1997. Wolbachia -induced delay of paternal chromatin condensation does not prevent maternal chromosomes from entering anaphase in incompatible crosses of Drosophila simulans . J Cell Sci 110: 271\u2013280. [PubMed]","DOI":"10.1242\/jcs.110.2.271"},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","unstructured":"Landmann F Orsi GA Loppin B Sullivan W. 2009. Wolbachia -mediated cytoplasmic incompatibility is associated with impaired histone deposition in the male pronucleus. PLoS Pathog 5: e1000343 http:\/\/dx.doi.org\/10.1371\/journal.ppat.1000343. [PubMed]","DOI":"10.1371\/journal.ppat.1000343"},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","unstructured":"Zabalou S Apostolaki A Pattas S Veneti Z Paraskevopoulos C Livadaras I Markakis G Brissac T Mer\u00e7ot H Bourtzis K. 2008. Multiple rescue factors within a Wolbachia strain. Genetics 178: 2145\u20132160 http:\/\/dx.doi.org\/10.1534\/genetics.107.086488.","DOI":"10.1534\/genetics.107.086488"},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","unstructured":"Atyame CM Labb\u00e9 P Dumas E Milesi P Charlat S Fort P Weill M. 2014. Wolbachia divergence and the evolution of cytoplasmic incompatibility in Culex pipiens . PLoS One 9: e87336 http:\/\/dx.doi.org\/10.1371\/journal.pone.0087336.","DOI":"10.1371\/journal.pone.0087336"},{"key":"e_1_3_2_54_2","doi-asserted-by":"crossref","unstructured":"Atyame CM Duron O Tortosa P Pasteur N Fort P Weill M. 2011. Multiple Wolbachia determinants control the evolution of cytoplasmic incompatibilities in Culex pipiens mosquito populations. Mol Ecol 20: 286\u2013298 http:\/\/dx.doi.org\/10.1111\/j.1365-294X.2010.04937.x.","DOI":"10.1111\/j.1365-294X.2010.04937.x"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","unstructured":"Beckmann JF Bonneau M Chen H Hochstrasser M Poinsot D Mer\u00e7ot H Weill M Sicard M Charlat S. 2019. The toxin-antidote model of cytoplasmic incompatibility: genetics and evolutionary implications. Trends Genet 35: 175\u2013185.","DOI":"10.1016\/j.tig.2018.12.004"},{"key":"e_1_3_2_56_2","doi-asserted-by":"crossref","unstructured":"Atyame CM Delsuc F Pasteur N Weill M Duron O. 2011. Diversification of Wolbachia endosymbiont in the Culex pipiens mosquito. Mol Biol Evol 28: 2761\u20132772 http:\/\/dx.doi.org\/10.1093\/molbev\/msr083.","DOI":"10.1093\/molbev\/msr083"},{"key":"e_1_3_2_57_2","doi-asserted-by":"crossref","unstructured":"Bonneau M Atyame C Beji M Justy F Cohen-Gonsaud M Sicard M Weill M. 2018. Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia . Nat Commun 9: 319.","DOI":"10.1038\/s41467-017-02749-w"},{"key":"e_1_3_2_58_2","doi-asserted-by":"crossref","unstructured":"Choe KN Moldovan GL. 2017. Forging ahead through darkness: PCNA still the principal conductor at the replication fork. Mol Cell 65: 380\u2013392.","DOI":"10.1016\/j.molcel.2016.12.020"},{"key":"e_1_3_2_59_2","doi-asserted-by":"crossref","unstructured":"Jaenike J. 2007. Spontaneous emergence of a new Wolbachia phenotype. Evolution 61: 2244\u20132252 http:\/\/dx.doi.org\/10.1111\/j.1558-5646.2007.00180.x.","DOI":"10.1111\/j.1558-5646.2007.00180.x"},{"key":"e_1_3_2_60_2","doi-asserted-by":"crossref","unstructured":"Sasaki T Massaki N Kubo T. 2005. Wolbachia variant that induces two distinct reproductive phenotypes in different hosts. Hered Edinb 95: 389\u2013393 http:\/\/dx.doi.org\/10.1038\/sj.hdy.6800737.","DOI":"10.1038\/sj.hdy.6800737"},{"key":"e_1_3_2_61_2","doi-asserted-by":"crossref","unstructured":"Moran NA McCutcheon JP Nakabachi A. 2008. Genomics and evolution of heritable bacterial symbionts. Annu Rev Genet 42: 165\u2013190 http:\/\/dx.doi.org\/10.1146\/annurev.genet.41.110306.130119.","DOI":"10.1146\/annurev.genet.41.110306.130119"},{"key":"e_1_3_2_62_2","doi-asserted-by":"crossref","unstructured":"Telschow A Flor M Kobayashi Y Hammerstein P Werren JH. 2007. Wolbachia -induced unidirectional cytoplasmic incompatibility and speciation: mainland-island model. PLoS One 2: e701 http:\/\/dx.doi.org\/10.1371\/journal.pone.0000701.","DOI":"10.1371\/journal.pone.0000701"},{"key":"e_1_3_2_63_2","doi-asserted-by":"crossref","unstructured":"Rokas A. 2000. Wolbachia as a speciation agent. Trends Ecol Evol 15: 44\u201345.","DOI":"10.1016\/S0169-5347(99)01783-8"},{"key":"e_1_3_2_64_2","doi-asserted-by":"crossref","unstructured":"Karr TL Ballard B. 2006. Speciation and Wolbachia p 245\u2013260. In Encyclopedia of Life Sciences . John Wiley & Sons Ltd Chichester United Kingdom. http:\/\/dx.doi.org\/10.1038\/npg.els.0001758.","DOI":"10.1038\/npg.els.0001758"},{"key":"e_1_3_2_65_2","doi-asserted-by":"crossref","unstructured":"Chang C-W Nashchekin D Wheatley L Irion U Dahlgaard K Montague TG Hall J St Johnston D. 2011. Anterior-posterior axis specification in Drosophila oocytes: identification of novel bicoid and oskar mRNA localization factors. Genetics 188: 883\u2013896 http:\/\/dx.doi.org\/10.1534\/genetics.111.129312.","DOI":"10.1534\/genetics.111.129312"},{"key":"e_1_3_2_66_2","doi-asserted-by":"crossref","unstructured":"Frydman HM Li JM Robson DN Wieschaus E. 2006. Somatic stem cell niche tropism in Wolbachia . Nature 441: 509\u2013512 http:\/\/dx.doi.org\/10.1038\/nature04756.","DOI":"10.1038\/nature04756"},{"key":"e_1_3_2_67_2","doi-asserted-by":"crossref","unstructured":"Toomey ME Panaram K Fast EM Beatty C Frydman HM. 2013. Evolutionarily conserved Wolbachia -encoded factors control pattern of stem-cell niche tropism in Drosophila ovaries and favor infection. Proc Natl Acad Sci USA 110: 10788\u201310793 http:\/\/dx.doi.org\/10.1073\/pnas.1301524110.","DOI":"10.1073\/pnas.1301524110"},{"key":"e_1_3_2_68_2","doi-asserted-by":"crossref","unstructured":"Kamath AD Deehan MA Frydman HM. 2018. Polar cell fate stimulates Wolbachia intracellular growth. Development 145: 158097.","DOI":"10.1242\/dev.158097"},{"key":"e_1_3_2_69_2","doi-asserted-by":"crossref","unstructured":"Steinhauer J Kalderon D. 2006. Microtubule polarity and axis formation in the Drosophila oocyte. Dev Dyn 235: 1455\u20131468 http:\/\/dx.doi.org\/10.1002\/dvdy.20770.","DOI":"10.1002\/dvdy.20770"},{"key":"e_1_3_2_70_2","doi-asserted-by":"crossref","unstructured":"Ferree PM Frydman HM Li JM Cao J Wieschaus E Sullivan W. 2005. Wolbachia utilizes host microtubules and dynein for anterior localization in the Drosophila oocyte. PLoS Pathog 1: e14.","DOI":"10.1371\/journal.ppat.0010014"},{"key":"e_1_3_2_71_2","doi-asserted-by":"crossref","unstructured":"Serbus LR Sullivan W. 2007. A cellular basis for Wolbachia recruitment to the host germline. PLoS Pathog 3: 1930\u20131937 http:\/\/dx.doi.org\/10.1371\/journal.ppat.0030190.","DOI":"10.1371\/journal.ppat.0030190"},{"key":"e_1_3_2_72_2","doi-asserted-by":"crossref","unstructured":"Newton ILG Savytskyy O Sheehan KB. 2015. Wolbachia utilize host actin for efficient maternal transmission in Drosophila melanogaster . PLoS Pathog 11: e1004798 http:\/\/dx.doi.org\/10.1371\/journal.ppat.1004798.","DOI":"10.1371\/journal.ppat.1004798"},{"key":"e_1_3_2_73_2","doi-asserted-by":"crossref","unstructured":"Melnikow E Xu S Liu J Bell AJ Ghedin E Unnasch TR Lustigman S. 2013. A potential role for the interaction of Wolbachia surface proteins with the Brugia malayi glycolytic enzymes and cytoskeleton in maintenance of endosymbiosis. PLoS Negl Trop Dis 7: e2151 http:\/\/dx.doi.org\/10.1371\/journal.pntd.0002151.","DOI":"10.1371\/journal.pntd.0002151"},{"key":"e_1_3_2_74_2","unstructured":"Fattouh N Cazevieille C Landmann F. Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress. PLoS Negl Trop Dis in press."},{"key":"e_1_3_2_75_2","doi-asserted-by":"crossref","unstructured":"Albertson R Casper-Lindley C Cao J Tram U Sullivan W. 2009. Symmetric and asymmetric mitotic segregation patterns influence Wolbachia distribution in host somatic tissue. J Cell Sci 122: 4570\u20134583 http:\/\/dx.doi.org\/10.1242\/jcs.054981.","DOI":"10.1242\/jcs.054981"},{"key":"e_1_3_2_76_2","doi-asserted-by":"crossref","unstructured":"Foster JM Hoerauf A Slatko BE Taylor MJ. 2013. The Wolbachia bacterial endosymbionts of filarial nematodes p 308\u2013336. In Kennedy MW Harnett W (ed) Parasitic Nematodes: Molecular Biology Biochemistry and Immunology 2nd ed. CABI Wallingford United Kingdom.","DOI":"10.1079\/9781845937591.0308"},{"key":"e_1_3_2_77_2","doi-asserted-by":"crossref","unstructured":"Howells RE Mendis AM Bray PG. 1983. The mechanisms of amino acid uptake by Brugia pahangi in vitro. Z Parasitenkd 69: 247\u2013253.","DOI":"10.1007\/BF00926960"},{"key":"e_1_3_2_78_2","doi-asserted-by":"crossref","unstructured":"Landmann F Foster JM Slatko B Sullivan W. 2010. Asymmetric Wolbachia segregation during early Brugia malayi embryogenesis determines its distribution in adult host tissues. PLoS Negl Trop Dis 4: e758 http:\/\/dx.doi.org\/10.1371\/journal.pntd.0000758.","DOI":"10.1371\/journal.pntd.0000758"},{"key":"e_1_3_2_79_2","doi-asserted-by":"crossref","unstructured":"Lefoulon E Gavotte L Junker K Barbuto M Uni S Landmann F Laaksonen S Saari S Nikander S de Souza Lima S Casiraghi M Bain O Martin C. 2012. A new type F Wolbachia from Splendidofilariinae (Onchocercidae) supports the recent emergence of this supergroup. Int J Parasitol 42: 1025\u20131036 http:\/\/dx.doi.org\/10.1016\/j.ijpara.2012.09.004.","DOI":"10.1016\/j.ijpara.2012.09.004"},{"key":"e_1_3_2_80_2","doi-asserted-by":"crossref","unstructured":"Landmann F Foster JM Michalski ML Slatko BE Sullivan W. 2014. Co-evolution between an endosymbiont and its nematode host: Wolbachia asymmetric posterior localization and AP polarity establishment. PLoS Negl Trop Dis 8: e3096 http:\/\/dx.doi.org\/10.1371\/journal.pntd.0003096.","DOI":"10.1371\/journal.pntd.0003096"},{"key":"e_1_3_2_81_2","doi-asserted-by":"crossref","unstructured":"Landmann F Bain O Martin C Uni S Taylor MJ Sullivan W. 2012. Both asymmetric mitotic segregation and cell-to-cell invasion are required for stable germline transmission of Wolbachia in filarial nematodes. Biol Open 1: 536\u2013547 http:\/\/dx.doi.org\/10.1242\/bio.2012737.","DOI":"10.1242\/bio.2012737"},{"key":"e_1_3_2_82_2","doi-asserted-by":"crossref","unstructured":"Fast EM Toomey ME Panaram K Desjardins D Kolaczyk ED Frydman HM. 2011. Wolbachia enhance Drosophila stem cell proliferation and target the germline stem cell niche. Science 334: 990\u2013992 http:\/\/dx.doi.org\/10.1126\/science.1209609.","DOI":"10.1126\/science.1209609"},{"key":"e_1_3_2_83_2","doi-asserted-by":"crossref","unstructured":"Landmann F Voronin D Sullivan W Taylor MJ. 2011. Anti-filarial activity of antibiotic therapy is due to extensive apoptosis after Wolbachia depletion from filarial nematodes. PLoS Pathog 7: e1002351 http:\/\/dx.doi.org\/10.1371\/journal.ppat.1002351.","DOI":"10.1371\/journal.ppat.1002351"},{"key":"e_1_3_2_84_2","doi-asserted-by":"crossref","unstructured":"Foray V P\u00e9rez-Jim\u00e9nez MM Fattouh N Landmann F. 2018. Wolbachia control stem cell behavior and stimulate germline proliferation in filarial nematodes. Dev Cell 45: 198\u2013211.e3 http:\/\/dx.doi.org\/10.1016\/j.devcel.2018.03.017.","DOI":"10.1016\/j.devcel.2018.03.017"},{"key":"e_1_3_2_85_2","doi-asserted-by":"crossref","unstructured":"Flores HA Bubnell JE Aquadro CF Barbash DA. 2015. The Drosophila bag of marbles gene interacts genetically with Wolbachia and shows female-specific effects of divergence. PLoS Genet 11: e1005453 http:\/\/dx.doi.org\/10.1371\/journal.pgen.1005453.","DOI":"10.1371\/journal.pgen.1005453"},{"key":"e_1_3_2_86_2","doi-asserted-by":"crossref","unstructured":"Starr DJ Cline TW. 2002. A host parasite interaction rescues Drosophila oogenesis defects. Nature 418: 76\u201379 http:\/\/dx.doi.org\/10.1038\/nature00843.","DOI":"10.1038\/nature00843"},{"key":"e_1_3_2_87_2","doi-asserted-by":"crossref","unstructured":"Sun S Cline TW. 2009. Effects of Wolbachia infection and ovarian tumor mutations on sex-lethal germline functioning in Drosophila . Genetics 181: 1291\u20131301 http:\/\/dx.doi.org\/10.1534\/genetics.108.099374.","DOI":"10.1534\/genetics.108.099374"},{"key":"e_1_3_2_88_2","doi-asserted-by":"crossref","unstructured":"Hashiyama K Hayashi Y Kobayashi S. 2011. Drosophila Sex lethal gene initiates female development in germline progenitors. Science 333: 885\u2013888.","DOI":"10.1126\/science.1208146"},{"key":"e_1_3_2_89_2","doi-asserted-by":"crossref","unstructured":"Slaidina M Lehmann R. 2014. Translational control in germline stem cell development. J Cell Biol 207: 13\u201321 http:\/\/dx.doi.org\/10.1083\/jcb.201407102.","DOI":"10.1083\/jcb.201407102"},{"key":"e_1_3_2_90_2","doi-asserted-by":"crossref","unstructured":"Ote M Yamamoto D. 2018. Enhancing Nanos expression via the bacterial TomO protein is a conserved strategy used by the symbiont Wolbachia to fuel germ stem cell maintenance in infected Drosophila females. Arch Insect Biochem Physiol 98: e21471 http:\/\/dx.doi.org\/10.1002\/arch.21471.","DOI":"10.1002\/arch.21471"},{"key":"e_1_3_2_91_2","doi-asserted-by":"crossref","unstructured":"Dedeine F Vavre F Fleury F Loppin B Hochberg ME Bouletreau M. 2001. Removing symbiotic Wolbachia bacteria specifically inhibits oogenesis in a parasitic wasp. Proc Natl Acad Sci USA 98: 6247\u20136252 http:\/\/dx.doi.org\/10.1073\/pnas.101304298.","DOI":"10.1073\/pnas.101304298"},{"key":"e_1_3_2_92_2","doi-asserted-by":"crossref","unstructured":"Peterson JS Timmons AK Mondragon AA McCall K. 2015. The end of the beginning; cell death in the germline. Curr Top Dev Biol 114: 93\u2013119.","DOI":"10.1016\/bs.ctdb.2015.07.025"},{"key":"e_1_3_2_93_2","doi-asserted-by":"crossref","unstructured":"Gumienny TL Lambie E Hartwieg E Horvitz HR Hengartner MO. 1999. Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. Development 126: 1011\u20131022.","DOI":"10.1242\/dev.126.5.1011"},{"key":"e_1_3_2_94_2","doi-asserted-by":"crossref","unstructured":"Pannebakker BA Loppin B Elemans CPH Humblot L Vavre F. 2007. Parasitic inhibition of cell death facilitates symbiosis. Proc Natl Acad Sci USA 104: 213\u2013215 http:\/\/dx.doi.org\/10.1073\/pnas.0607845104.","DOI":"10.1073\/pnas.0607845104"},{"key":"e_1_3_2_95_2","doi-asserted-by":"crossref","unstructured":"Desjardins CA Cerqueira GC Goldberg JM Dunning Hotopp JC Haas BJ Zucker J Ribeiro JM Saif S Levin JZ Fan L Zeng Q Russ C Wortman JR Fink DL Birren BW Nutman TB. 2013. Genomics of Loa loa a Wolbachia -free filarial parasite of humans. Nat Genet 45: 495\u2013500 http:\/\/dx.doi.org\/10.1038\/ng.2585.","DOI":"10.1038\/ng.2585"},{"key":"e_1_3_2_96_2","doi-asserted-by":"crossref","unstructured":"Voronin D Bachu S Shlossman M Unnasch TR Ghedin E Lustigman S. 2016. Glucose and glycogen metabolism in brugia malayi is associated with Wolbachia symbiont fitness. PLoS One 11: e0153812 http:\/\/dx.doi.org\/10.1371\/journal.pone.0153812.","DOI":"10.1371\/journal.pone.0153812"},{"key":"e_1_3_2_97_2","doi-asserted-by":"crossref","unstructured":"Sullivan W. 2017. Wolbachia bottled water and the dark side of symbiosis. Mol Biol Cell 28: 2343\u20132346 http:\/\/dx.doi.org\/10.1091\/mbc.e17-02-0132.","DOI":"10.1091\/mbc.e17-02-0132"},{"key":"e_1_3_2_98_2","doi-asserted-by":"crossref","unstructured":"Fry AJ Palmer MR Rand DM. 2004. Variable fitness effects of Wolbachia infection in Drosophila melanogaster . Hered Edinb 93: 379\u2013389 http:\/\/dx.doi.org\/10.1038\/sj.hdy.6800514.","DOI":"10.1038\/sj.hdy.6800514"},{"key":"e_1_3_2_99_2","doi-asserted-by":"crossref","unstructured":"Fraser JE De Bruyne JT Iturbe-Ormaetxe I Stepnell J Burns RL Flores HA O\u2019Neill SL. 2017. Novel Wolbachia -transinfected Aedes aegypti mosquitoes possess diverse fitness and vector competence phenotypes. PLoS Pathog 13: e1006751 http:\/\/dx.doi.org\/10.1371\/journal.ppat.1006751.","DOI":"10.1371\/journal.ppat.1006751"},{"key":"e_1_3_2_100_2","doi-asserted-by":"crossref","unstructured":"Maistrenko OM Serga SV Vaiserman AM Kozeretska IA. 2016. Longevity-modulating effects of symbiosis: insights from Drosophila - Wolbachia interaction. Biogerontology 17: 785\u2013803 http:\/\/dx.doi.org\/10.1007\/s10522-016-9653-9.","DOI":"10.1007\/s10522-016-9653-9"},{"key":"e_1_3_2_101_2","doi-asserted-by":"crossref","unstructured":"Alexandrov ID Alexandrova MV Goryacheva II Rochina NV Shaikevich EV Zakharov IA. 2007. Removing endosymbiotic Wolbachia specifically decreases lifespan of females and competitiveness in a laboratory strain of Drosophila melanogaster . Russ J Genet 43: 1147\u20131152 http:\/\/dx.doi.org\/10.1134\/S1022795407100080.","DOI":"10.1134\/S1022795407100080"},{"key":"e_1_3_2_102_2","doi-asserted-by":"crossref","unstructured":"Kremer N Voronin D Charif D Mavingui P Mollereau B Vavre F. 2009. Wolbachia interferes with ferritin expression and iron metabolism in insects. PLoS Pathog 5: e1000630 http:\/\/dx.doi.org\/10.1371\/journal.ppat.1000630.","DOI":"10.1371\/journal.ppat.1000630"},{"key":"e_1_3_2_103_2","doi-asserted-by":"crossref","unstructured":"Hosokawa T Koga R Kikuchi Y Meng X-Y Fukatsu T. 2010. Wolbachia as a bacteriocyte-associated nutritional mutualist. Proc Natl Acad Sci USA 107: 769\u2013774 http:\/\/dx.doi.org\/10.1073\/pnas.0911476107.","DOI":"10.1073\/pnas.0911476107"},{"key":"e_1_3_2_104_2","doi-asserted-by":"crossref","unstructured":"Moriyama M Nikoh N Hosokawa T Fukatsu T. 2015. Riboflavin provisioning underlies Wolbachia \u2019s fitness contribution to its insect host. mBio 6: e01732-15.","DOI":"10.1128\/mBio.01732-15"},{"key":"e_1_3_2_105_2","doi-asserted-by":"crossref","unstructured":"Ikeya T Broughton S Alic N Grandison R Partridge L. 2009. The endosymbiont Wolbachia increases insulin\/IGF-like signalling in Drosophila . Proc Biol Sci 276: 3799\u20133807 http:\/\/dx.doi.org\/10.1098\/rspb.2009.0778.","DOI":"10.1098\/rspb.2009.0778"},{"key":"e_1_3_2_106_2","doi-asserted-by":"crossref","unstructured":"Eleftherianos I Atri J Accetta J Castillo JC. 2013. Endosymbiotic bacteria in insects: guardians of the immune system? Front Physiol 4: 46 http:\/\/dx.doi.org\/10.3389\/fphys.2013.00046.","DOI":"10.3389\/fphys.2013.00046"},{"key":"e_1_3_2_107_2","doi-asserted-by":"crossref","unstructured":"Hoffmann AA Iturbe-Ormaetxe I Callahan AG Phillips BL Billington K Axford JK Montgomery B Turley AP O\u2019Neill SL. 2014. Stability of the wMel Wolbachia infection following invasion into Aedes aegypti populations. PLoS Negl Trop Dis 8: e3115 http:\/\/dx.doi.org\/10.1371\/journal.pntd.0003115.","DOI":"10.1371\/journal.pntd.0003115"},{"key":"e_1_3_2_108_2","doi-asserted-by":"crossref","unstructured":"Hoffmann AA Montgomery BL Popovici J Iturbe-Ormaetxe I Johnson PH Muzzi F Greenfield M Durkan M Leong YS Dong Y Cook H Axford J Callahan AG Kenny N Omodei C McGraw EA Ryan PA Ritchie SA Turelli M O\u2019Neill SL. 2011. Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature 476: 454\u2013457 http:\/\/dx.doi.org\/10.1038\/nature10356.","DOI":"10.1038\/nature10356"},{"key":"e_1_3_2_109_2","doi-asserted-by":"crossref","unstructured":"Teixeira L Ferreira A Ashburner M. 2008. The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster . PLoS Biol 6: 2753\u20132763 http:\/\/dx.doi.org\/10.1371\/journal.pbio.1000002.","DOI":"10.1371\/journal.pbio.1000002"},{"key":"e_1_3_2_110_2","doi-asserted-by":"crossref","unstructured":"Moreira LA Iturbe-Ormaetxe I Jeffery JA Lu G Pyke AT Hedges LM Rocha BC Hall-Mendelin S Day A Riegler M Hugo LE Johnson KN Kay BH McGraw EA van den Hurk AF Ryan PA O\u2019Neill SL. 2009. A Wolbachia symbiont in Aedes aegypti limits infection with dengue Chikungunya and Plasmodium . Cell 139: 1268\u20131278 http:\/\/dx.doi.org\/10.1016\/j.cell.2009.11.042.","DOI":"10.1016\/j.cell.2009.11.042"},{"key":"e_1_3_2_111_2","doi-asserted-by":"crossref","unstructured":"Caragata EP Dutra HL O\u2019Neill SL Moreira LA. 2016. Zika control through the bacterium Wolbachia pipientis . Future Microbiol 11: 1499\u20131502 http:\/\/dx.doi.org\/10.2217\/fmb-2016-0177.","DOI":"10.2217\/fmb-2016-0177"},{"key":"e_1_3_2_112_2","doi-asserted-by":"crossref","unstructured":"Bian G Xu Y Lu P Xie Y Xi Z. 2010. The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti . PLoS Pathog 6: e1000833 http:\/\/dx.doi.org\/10.1371\/journal.ppat.1000833.","DOI":"10.1371\/journal.ppat.1000833"},{"key":"e_1_3_2_113_2","doi-asserted-by":"crossref","unstructured":"Frentiu FD Zakir T Walker T Popovici J Pyke AT van den Hurk A McGraw EA O\u2019Neill SL. 2014. Limited dengue virus replication in field-collected Aedes aegypti mosquitoes infected with Wolbachia . PLoS Negl Trop Dis 8: e2688 http:\/\/dx.doi.org\/10.1371\/journal.pntd.0002688.","DOI":"10.1371\/journal.pntd.0002688"},{"key":"e_1_3_2_114_2","doi-asserted-by":"crossref","unstructured":"Jiggins FM. 2017. The spread of Wolbachia through mosquito populations. PLoS Biol 15: e2002780 http:\/\/dx.doi.org\/10.1371\/journal.pbio.2002780.","DOI":"10.1371\/journal.pbio.2002780"},{"key":"e_1_3_2_115_2","doi-asserted-by":"crossref","unstructured":"Lin M Rikihisa Y. 2003. Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival. Infect Immun 71: 5324\u20135331 http:\/\/dx.doi.org\/10.1128\/IAI.71.9.5324-5331.2003.","DOI":"10.1128\/IAI.71.9.5324-5331.2003"},{"key":"e_1_3_2_116_2","doi-asserted-by":"crossref","unstructured":"Geoghegan V Stainton K Rainey SM Ant TH Dowle AA Larson T Hester S Charles PD Thomas B Sinkins SP. 2017. Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia -infected Aedes aegypti cells. Nat Commun 8: 526 http:\/\/dx.doi.org\/10.1038\/s41467-017-00610-8.","DOI":"10.1038\/s41467-017-00610-8"},{"key":"e_1_3_2_117_2","doi-asserted-by":"crossref","unstructured":"Taylor MJ Hoerauf A Bockarie M. 2010. Lymphatic filariasis and onchocerciasis. Lancet 376: 1175\u20131185 http:\/\/dx.doi.org\/10.1016\/S0140-6736(10)60586-7.","DOI":"10.1016\/S0140-6736(10)60586-7"},{"key":"e_1_3_2_118_2","doi-asserted-by":"crossref","unstructured":"McCall JW Genchi C Kramer LH Guerrero J Venco L. 2008. Heartworm disease in animals and humans. Adv Parasitol 66: 193\u2013285 http:\/\/dx.doi.org\/10.1016\/S0065-308X(08)00204-2.","DOI":"10.1016\/S0065-308X(08)00204-2"},{"key":"e_1_3_2_119_2","doi-asserted-by":"crossref","unstructured":"Hildebrandt JC Eisenbarth A Renz A Streit A. 2014. Reproductive biology of Onchocerca ochengi a nodule forming filarial nematode in zebu cattle. Vet Parasitol 205: 318\u2013329 http:\/\/dx.doi.org\/10.1016\/j.vetpar.2014.06.006.","DOI":"10.1016\/j.vetpar.2014.06.006"},{"key":"e_1_3_2_120_2","doi-asserted-by":"crossref","unstructured":"Taylor MJ Makunde WH McGarry HF Turner JD Mand S Hoerauf A. 2005. Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti : a double-blind randomised placebo-controlled trial. Lancet 365: 2116\u20132121 http:\/\/dx.doi.org\/10.1016\/S0140-6736(05)66591-9.","DOI":"10.1016\/S0140-6736(05)66591-9"},{"key":"e_1_3_2_121_2","doi-asserted-by":"crossref","unstructured":"Slatko BE Taylor MJ Foster JM. 2010. The Wolbachia endosymbiont as an anti-filarial nematode target. Symbiosis 51: 55\u201365 http:\/\/dx.doi.org\/10.1007\/s13199-010-0067-1.","DOI":"10.1007\/s13199-010-0067-1"},{"key":"e_1_3_2_122_2","doi-asserted-by":"crossref","unstructured":"Turner JD Sharma R Al Jayoussi G Tyrer HE Gamble J Hayward L Priestley RS Murphy EA Davies J Waterhouse D Cook DAN Clare RH Cassidy A Steven A Johnston KL McCall J Ford L Hemingway J Ward SA Taylor MJ. 2017. Albendazole and antibiotics synergize to deliver short-course anti- Wolbachia curative treatments in preclinical models of filariasis. Proc Natl Acad Sci USA 114: E9712\u2013E9721 http:\/\/dx.doi.org\/10.1073\/pnas.1710845114.","DOI":"10.1073\/pnas.1710845114"},{"key":"e_1_3_2_123_2","doi-asserted-by":"crossref","unstructured":"Hansen RDE Trees AJ Bah GS Hetzel U Martin C Bain O Tanya VN Makepeace BL. 2011. A worm\u2019s best friend: recruitment of neutrophils by Wolbachia confounds eosinophil degranulation against the filarial nematode Onchocerca ochengi . Proc Biol Sci 278: 2293\u20132302 http:\/\/dx.doi.org\/10.1098\/rspb.2010.2367.","DOI":"10.1098\/rspb.2010.2367"},{"key":"e_1_3_2_124_2","doi-asserted-by":"crossref","unstructured":"Brattig NW Bazzocchi C Kirschning CJ Reiling N B\u00fcttner DW Ceciliani F Geisinger F Hochrein H Ernst M Wagner H Bandi C Hoerauf A. 2004. The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4. J Immunol 173: 437\u2013445 http:\/\/dx.doi.org\/10.4049\/jimmunol.173.1.437.","DOI":"10.4049\/jimmunol.173.1.437"},{"key":"e_1_3_2_125_2","doi-asserted-by":"crossref","unstructured":"Darby AC Armstrong SD Bah GS Kaur G Hughes MA Kay SM Koldkj\u00e6r P Rainbow L Radford AD Blaxter ML Tanya VN Trees AJ Cordaux R Wastling JM Makepeace BL. 2012. Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis. Genome Res 22: 2467\u20132477 http:\/\/dx.doi.org\/10.1101\/gr.138420.112.","DOI":"10.1101\/gr.138420.112"},{"key":"e_1_3_2_126_2","doi-asserted-by":"crossref","unstructured":"Chagas-Moutinho VA Silva R de Souza W Motta MCM. 2015. Identification and ultrastructural characterization of the Wolbachia symbiont in Litomosoides chagasfilhoi . Parasit Vectors 8: 74 http:\/\/dx.doi.org\/10.1186\/s13071-015-0668-x.","DOI":"10.1186\/s13071-015-0668-x"},{"key":"e_1_3_2_127_2","doi-asserted-by":"crossref","unstructured":"Fischer K Beatty WL Weil GJ Fischer PU. 2014. High pressure freezing\/freeze substitution fixation improves the ultrastructural assessment of Wolbachia endosymbiont-filarial nematode host interaction. PLoS One 9: e86383 http:\/\/dx.doi.org\/10.1371\/journal.pone.0086383.","DOI":"10.1371\/journal.pone.0086383"},{"key":"e_1_3_2_128_2","doi-asserted-by":"crossref","unstructured":"White PM Serbus LR Debec A Codina A Bray W Guichet A Lokey RS Sullivan W. 2017. Reliance of Wolbachia on high rates of host proteolysis revealed by a genome-wide RNAi screen of Drosophila cells. Genetics 205: 1473\u20131488 http:\/\/dx.doi.org\/10.1534\/genetics.116.198903.","DOI":"10.1534\/genetics.116.198903"},{"key":"e_1_3_2_129_2","doi-asserted-by":"crossref","unstructured":"White PM Pietri JE Debec A Russell S Patel B Sullivan W. 2017. Mechanisms of horizontal cell-to-cell transfer of Wolbachia spp. in Drosophila melanogaster . Appl Environ Microbiol 83: e03425-16 http:\/\/dx.doi.org\/10.1128\/AEM.03425-16.","DOI":"10.1128\/AEM.03425-16"},{"key":"e_1_3_2_130_2","doi-asserted-by":"crossref","unstructured":"Serbus LR White PM Silva JP Rabe A Teixeira L Albertson R Sullivan W. 2015. The impact of host diet on Wolbachia titer in Drosophila . PLoS Pathog 11: e1004777.","DOI":"10.1371\/journal.ppat.1004777"},{"key":"e_1_3_2_131_2","doi-asserted-by":"crossref","unstructured":"Fallon AM Witthuhn BA. 2009. Proteasome activity in a na\u00efve mosquito cell line infected with Wolbachia pipientis wAlbB. In Vitro Cell Dev Biol Anim 45: 460\u2013466.","DOI":"10.1007\/s11626-009-9193-6"},{"key":"e_1_3_2_132_2","doi-asserted-by":"crossref","unstructured":"Xi Z Gavotte L Xie Y Dobson SL. 2008. Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila host. BMC Genomics 9: 1\u201312 http:\/\/dx.doi.org\/10.1186\/1471-2164-9-1.","DOI":"10.1186\/1471-2164-9-1"},{"key":"e_1_3_2_133_2","doi-asserted-by":"crossref","unstructured":"Grobler Y Yun CY Kahler DJ Bergman CM Lee H Oliver B Lehmann R. 2018. Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation. PLoS Pathog 14: e1007445 http:\/\/dx.doi.org\/10.1371\/journal.ppat.1007445.","DOI":"10.1371\/journal.ppat.1007445"},{"key":"e_1_3_2_134_2","unstructured":"Lefoulon E. 2015. L\u2019association tripartie Wolbachia - n\u00e9matode Onchocercidae - vert\u00e9br\u00e9: de l\u2019histoire \u00e9volutive au dialogue mol\u00e9culaire entre les trois partenaires. Thesis National museum of natural history Paris France."}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/microbiolspec.BAI-0018-2019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/microbiolspec.BAI-0018-2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T08:18:54Z","timestamp":1646727534000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/microbiolspec.BAI-0018-2019"}},"subtitle":[],"editor":[{"given":"Pascale","family":"Cossart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Craig R.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Philippe","family":"Sansonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,12]]},"references-count":133,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4,12]]}},"alternative-id":["10.1128\/microbiolspec.BAI-0018-2019"],"URL":"https:\/\/doi.org\/10.1128\/microbiolspec.bai-0018-2019","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,12]]},"assertion":[{"value":"2018-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7.2.25"}}