{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:52:31Z","timestamp":1794329551082,"version":"4.9.0"},"reference-count":137,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2019,4,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Shigella<\/jats:italic>\n                    is a genus of Gram-negative enteropathogens that have long been, and continue to be, an important public health concern worldwide. Over the past several decades,\n                    <jats:italic>Shigella<\/jats:italic>\n                    spp. have also served as model pathogens in the study of bacterial pathogenesis, and\n                    <jats:italic>Shigella flexneri<\/jats:italic>\n                    has become one of the best-studied pathogens on a molecular, cellular, and tissue level. In the arms race between\n                    <jats:italic>Shigella<\/jats:italic>\n                    and the host immune system,\n                    <jats:italic>Shigella<\/jats:italic>\n                    has developed highly sophisticated mechanisms to subvert host cell processes in order to promote infection, escape immune detection, and prevent bacterial clearance. Here, we give an overview of\n                    <jats:italic>Shigella<\/jats:italic>\n                    pathogenesis while highlighting innovative techniques and methods whose application has significantly advanced our understanding of\n                    <jats:italic>Shigella<\/jats:italic>\n                    pathogenesis in recent years.\n                  <\/jats:p>","DOI":"10.1128\/microbiolspec.bai-0023-2019","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T08:30:17Z","timestamp":1554539417000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":174,"title":["<i>Shigella<\/i>\n                    Pathogenesis: New Insights through Advanced Methodologies"],"prefix":"10.1128","volume":"7","author":[{"given":"Pamela","family":"Schnupf","sequence":"first","affiliation":[{"name":"Institut Imagine, Laboratory of Intestinal Immunity, INSERM UMR1163; Institut Necker Enfants Malades, Laboratory of Host-Microbiota Interaction, INSERM U1151; and Universit\u00e9 Paris Descartes-Sorbonne, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe J.","family":"Sansonetti","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Pathog\u00e9nie Microbienne Mol\u00e9culaire, INSERM U1202, and College de France, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Trofa AF Ueno-Olsen H Oiwa R Yoshikawa M. 1999. 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