{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:59:45Z","timestamp":1790787585978,"version":"4.1.0"},"reference-count":115,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2019,5,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    is an ancient master of the art of causing human disease. One important weapon within its fully loaded arsenal is the type VII secretion system.\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    has five of them: ESAT-6 secretion systems (ESX) 1 to 5. ESX-1 has long been recognized as a major cause of attenuation of the FDA-licensed vaccine\n                    <jats:italic>Mycobacterium bovis<\/jats:italic>\n                    BCG, but its importance in disease progression and transmission has recently been elucidated in more detail. This review summarizes the recent advances in (i) the understanding of the ESX-1 structure and components, (ii) our knowledge of ESX-1\u2019s role in hijacking macrophage function to set a path for infection and dissemination, and (iii) the development of interventions that utilize ESX-1 for diagnosis, drug interventions, host-directed therapies, and vaccines.\n                  <\/jats:p>","DOI":"10.1128\/microbiolspec.bai-0024-2019","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T08:45:18Z","timestamp":1559897118000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["Infect and Inject: How\n                    <i>Mycobacterium tuberculosis<\/i>\n                    Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1"],"prefix":"10.1128","volume":"7","author":[{"given":"Sangeeta","family":"Tiwari","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalyn","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Microbial Sciences, School of Biosciences and Medicine, University of Surrey, Guilford, Surrey, GU27XH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia W.","family":"Goulding","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology &amp; Biochemistry and Department of Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzie","family":"Hingley-Wilson","sequence":"additional","affiliation":[{"name":"Department of Microbial Sciences, School of Biosciences and Medicine, University of Surrey, Guilford, Surrey, GU27XH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William R.","family":"Jacobs, Jr.","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization. 2018. 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