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This includes necrotizing pneumonia, necrotizing fasciitis, and to some extent toxic shock syndrome and infective endocarditis. In the three former diseases, toxin production plays a major role whereas in the latter (fulminant presentation of infective endocarditis), association with any particular toxinic profile has never been demonstrated. This article reviews the clinical, pathophysiological, and therapeutic aspects of these diseases.<\/jats:p>","DOI":"10.1128\/microbiolspec.gpp3-0036-2018","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T12:45:12Z","timestamp":1538829912000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Fulminant Staphylococcal Infections"],"prefix":"10.1128","volume":"6","author":[{"given":"Yves","family":"Gillet","sequence":"first","affiliation":[{"name":"Department of Pediatric Emergency, Hospices Civils de Lyon, H\u00f4pital Femme M\u00e8re Enfant, F-69677, Bron, France"},{"name":"CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon, University of Lyon, F-69007, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Henry","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon, University of Lyon, F-69007, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Vandenesch","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon, University of Lyon, F-69007, Lyon, France"},{"name":"IAI, Institut des Agents Infectieux, National Reference Center for Staphylococci, Hospices Civils de Lyon, H\u00f4pital de la Croix Rousse, F-69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","unstructured":"Patterson CM Loebinger MR. 2012. 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