{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:56:47Z","timestamp":1784642207947,"version":"3.55.0"},"reference-count":102,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2019,7,19]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cell-mediated immunity seems to be critical for prevention and resolution of invasive<jats:italic>S. aureus<\/jats:italic>infections, but an imbalance in this immunity may also produce SIRS and death or an inadequate protective response with prolonged bacteremia and death. This dysregulation is likely at the heart of mortality and severe disease in humans. Anti-toxin antibodies may also come into play in reducing the severity of<jats:italic>S. aureus<\/jats:italic>infections, but these antibodies might also address superantigen-induced immune dysregulation. Thus, while changing intrinsic T cell responses may be therapeutically difficult, monoclonal antibodies against superantigens may have utility in addressing dysfunctional immune responses to<jats:italic>S. aureus<\/jats:italic>. The models above are hypotheses for examining, and potentially dramatically improving immune response to and safety of<jats:italic>S. aureus<\/jats:italic>vaccines.<\/jats:p>","DOI":"10.1128\/microbiolspec.gpp3-0037-2018","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T12:45:26Z","timestamp":1562935526000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Immunity to<i>Staphylococcus aureus<\/i>: Implications for Vaccine Development"],"prefix":"10.1128","volume":"7","author":[{"given":"Richard A.","family":"Proctor","sequence":"first","affiliation":[{"name":"University of Wisconsin, Medical Microbiology\/Immunology, Madison, WI 53705"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","unstructured":"Fowler VG Jr Proctor RA. 2014. Where does a Staphylococcus aureus vaccine stand? Clin Microbiol Infect 20 (Suppl 5) : 66\u201375 http:\/\/dx.doi.org\/10.1111\/1469-0691.12570. [PubMed]","DOI":"10.1111\/1469-0691.12570"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","unstructured":"Proctor RA. 2012. Is there a future for a Staphylococcus aureus vaccine? Vaccine 30: 2921\u20132927 http:\/\/dx.doi.org\/10.1016\/j.vaccine.2011.11.006. [PubMed]","DOI":"10.1016\/j.vaccine.2011.11.006"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","unstructured":"Proctor RA. 2012. Challenges for a universal Staphylococcus aureus vaccine. Clin Infect Dis 54: 1179\u20131186 http:\/\/dx.doi.org\/10.1093\/cid\/cis033. [PubMed]","DOI":"10.1093\/cid\/cis033"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","unstructured":"Proctor RA. 2015. Recent developments for Staphylococcus aureus vaccines: clinical and basic science challenges. Eur Cell Mater 30: 315\u2013326 http:\/\/dx.doi.org\/10.22203\/eCM.v030a22. [PubMed]","DOI":"10.22203\/eCM.v030a22"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","unstructured":"Kolata JB K\u00fchbandner I Link C Normann N Vu CH Steil L Weidenmaier C Br\u00f6ker BM. 2015. The fall of a dogma? Unexpected high T-cell memory response to Staphylococcus aureus in humans. J Infect Dis 212: 830\u2013838 http:\/\/dx.doi.org\/10.1093\/infdis\/jiv128. [PubMed]","DOI":"10.1093\/infdis\/jiv128"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","unstructured":"Salgado-Pab\u00f3n W Schlievert PM. 2014. Models matter: the search for an effective Staphylococcus aureus vaccine. Nat Rev Microbiol 12: 585\u2013591 http:\/\/dx.doi.org\/10.1038\/nrmicro3308. [PubMed]","DOI":"10.1038\/nrmicro3308"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","unstructured":"Daum RS Spellberg B. 2012. Progress toward a Staphylococcus aureus vaccine. Clin Infect Dis 54: 560\u2013567 http:\/\/dx.doi.org\/10.1093\/cid\/cir828. [PubMed]","DOI":"10.1093\/cid\/cir828"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","unstructured":"de Beaucoudrey L Puel A Filipe-Santos O Cobat A Ghandil P Chrabieh M Feinberg J von Bernuth H Samarina A Janni\u00e8re L Fieschi C St\u00e9phan JL Boileau C Lyonnet S Jondeau G Cormier-Daire V Le Merrer M Hoarau C Lebranchu Y Lortholary O Chandesris MO Tron F Gambineri E Bianchi L Rodriguez-Gallego C Zitnik SE Vasconcelos J Guedes M Vitor AB Marodi L Chapel H Reid B Roifman C Nadal D Reichenbach J Caragol I Garty BZ Dogu F Camcioglu Y G\u00fclle S Sanal O Fischer A Abel L Stockinger B Picard C Casanova JL. 2008. Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J Exp Med 205: 1543\u20131550 http:\/\/dx.doi.org\/10.1084\/jem.20080321. [PubMed]","DOI":"10.1084\/jem.20080321"},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","unstructured":"Joshi A Pancari G Cope L Bowman EP Cua D Proctor RA McNeely T. 2012. Immunization with Staphylococcus aureus iron regulated surface determinant B (IsdB) confers protection via Th17\/IL17 pathway in a murine sepsis model. Hum Vaccin Immunother 8: 336\u2013346 http:\/\/dx.doi.org\/10.4161\/hv.18946. [PubMed]","DOI":"10.4161\/hv.18946"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","unstructured":"Ma CS Chew GY Simpson N Priyadarshi A Wong M Grimbacher B Fulcher DA Tangye SG Cook MC. 2008. Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med 205: 1551\u20131557 http:\/\/dx.doi.org\/10.1084\/jem.20080218. [PubMed]","DOI":"10.1084\/jem.20080218"},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","unstructured":"Maher BM Mulcahy ME Murphy AG Wilk M O\u2019Keeffe KM Geoghegan JA Lavelle EC McLoughlin RM. 2013. Nlrp-3-driven interleukin 17 production by \u03b3\u03b4T cells controls infection outcomes during Staphylococcus aureus surgical site infection. Infect Immun 81: 4478\u20134489 http:\/\/dx.doi.org\/10.1128\/IAI.01026-13. [PubMed]","DOI":"10.1128\/IAI.01026-13"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","unstructured":"Miller LS Cho JS. 2011. Immunity against Staphylococcus aureus cutaneous infections. Nat Rev Immunol 11: 505\u2013518 http:\/\/dx.doi.org\/10.1038\/nri3010. [PubMed]","DOI":"10.1038\/nri3010"},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","unstructured":"Minegishi Y Saito M Nagasawa M Takada H Hara T Tsuchiya S Agematsu K Yamada M Kawamura N Ariga T Tsuge I Karasuyama H. 2009. Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J Exp Med 206: 1291\u20131301 http:\/\/dx.doi.org\/10.1084\/jem.20082767. [PubMed]","DOI":"10.1084\/jem.20082767"},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","unstructured":"Puel A Picard C Lorrot M Pons C Chrabieh M Lorenzo L Mamani-Matsuda M Jouanguy E Gendrel D Casanova JL. 2008. Recurrent staphylococcal cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6. J Immunol 180: 647\u2013654 http:\/\/dx.doi.org\/10.4049\/jimmunol.180.1.647. [PubMed]","DOI":"10.4049\/jimmunol.180.1.647"},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","unstructured":"Thomason J Rentsch C Stenehjem EA Hidron AI Rimland D. 2015. Association between vitamin D deficiency and methicillin-resistant Staphylococcus aureus infection. Infection 43: 715\u2013722 http:\/\/dx.doi.org\/10.1007\/s15010-015-0815-5. [PubMed]","DOI":"10.1007\/s15010-015-0815-5"},{"key":"e_1_3_1_17_2","doi-asserted-by":"crossref","unstructured":"Wang JW Hogan PG Hunstad DA Fritz SA. 2015. Vitamin D sufficiency and Staphylococcus aureus infection in children. Pediatr Infect Dis J 34: 544\u2013545 http:\/\/dx.doi.org\/10.1097\/INF.0000000000000667. [PubMed]","DOI":"10.1097\/INF.0000000000000667"},{"key":"e_1_3_1_18_2","doi-asserted-by":"crossref","unstructured":"van der Does AM Kenne E Koppelaar E Agerberth B Lindbom L. 2014. Vitamin D 3 and phenylbutyrate promote development of a human dendritic cell subset displaying enhanced antimicrobial properties. J Leukoc Biol 95: 883\u2013891 http:\/\/dx.doi.org\/10.1189\/jlb.1013549. [PubMed]","DOI":"10.1189\/jlb.1013549"},{"key":"e_1_3_1_19_2","doi-asserted-by":"crossref","unstructured":"O\u2019Keeffe KM Wilk MM Leech JM Murphy AG Laabei M Monk IR Massey RC Lindsay JA Foster TJ Geoghegan JA McLoughlin RM. 2015. Manipulation of autophagy in phagocytes facilitates Staphylococcus aureus bloodstream infection. Infect Immun 83: 3445\u20133457 http:\/\/dx.doi.org\/10.1128\/IAI.00358-15. [PubMed]","DOI":"10.1128\/IAI.00358-15"},{"key":"e_1_3_1_20_2","doi-asserted-by":"crossref","unstructured":"Hepburn L Prajsnar TK Klapholz C Moreno P Loynes CA Ogryzko NV Brown K Schiebler M Hegyi K Antrobus R Hammond KL Connolly J Ochoa B Bryant C Otto M Surewaard B Seneviratne SL Grogono DM Cachat J Ny T Kaser A T\u00f6r\u00f6k ME Peacock SJ Holden M Blundell T Wang L Ligoxygakis P Minichiello L Woods CG Foster SJ Renshaw SA Floto RA. 2014. Innate immunity. A Spaetzle-like role for nerve growth factor \u03b2 in vertebrate immunity to Staphylococcus aureus . Science 346: 641\u2013646 http:\/\/dx.doi.org\/10.1126\/science.1258705. [PubMed]","DOI":"10.1126\/science.1258705"},{"key":"e_1_3_1_21_2","doi-asserted-by":"crossref","unstructured":"Pacquelet S Johnson JL Ellis BA Brzezinska AA Lane WS Munafo DB Catz SD. 2007. Cross-talk between IRAK-4 and the NADPH oxidase. Biochem J 403: 451\u2013461 http:\/\/dx.doi.org\/10.1042\/BJ20061184. [PubMed]","DOI":"10.1042\/BJ20061184"},{"key":"e_1_3_1_22_2","doi-asserted-by":"crossref","unstructured":"Picard C von Bernuth H Ghandil P Chrabieh M Levy O Arkwright PD McDonald D Geha RS Takada H Krause JC Creech CB Ku CL Ehl S Mar\u00f3di L Al-Muhsen S Al-Hajjar S Al-Ghonaium A Day-Good NK Holland SM Gallin JI Chapel H Speert DP Rodriguez-Gallego C Colino E Garty BZ Roifman C Hara T Yoshikawa H Nonoyama S Domachowske J Issekutz AC Tang M Smart J Zitnik SE Hoarau C Kumararatne DS Thrasher AJ Davies EG Bethune C Sirvent N de Ricaud D Camcioglu Y Vasconcelos J Guedes M Vitor AB Rodrigo C Almaz\u00e1n F M\u00e9ndez M Ar\u00f3stegui JI Alsina L et al. 2010. Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore) 89: 403\u2013425 http:\/\/dx.doi.org\/10.1097\/MD.0b013e3181fd8ec3. [PubMed]","DOI":"10.1097\/MD.0b013e3181fd8ec3"},{"key":"e_1_3_1_23_2","doi-asserted-by":"crossref","unstructured":"Singh A Zarember KA Kuhns DB Gallin JI. 2009. Impaired priming and activation of the neutrophil NADPH oxidase in patients with IRAK4 or NEMO deficiency. J Immunol 182: 6410\u20136417 http:\/\/dx.doi.org\/10.4049\/jimmunol.0802512. [PubMed]","DOI":"10.4049\/jimmunol.0802512"},{"key":"e_1_3_1_24_2","doi-asserted-by":"crossref","unstructured":"van Bruggen R Drewniak A Tool AT Jansen M van Houdt M Geissler J van den Berg TK Chapel H Kuijpers TW. 2010. Toll-like receptor responses in IRAK-4-deficient neutrophils. J Innate Immun 2: 280\u2013287 http:\/\/dx.doi.org\/10.1159\/000268288. [PubMed]","DOI":"10.1159\/000268288"},{"key":"e_1_3_1_25_2","doi-asserted-by":"crossref","unstructured":"Tanaka T Narazaki M Kishimoto T. 2014. IL-6 in inflammation immunity and disease. Cold Spring Harb Perspect Biol 6: a016295 http:\/\/dx.doi.org\/10.1101\/cshperspect.a016295. [PubMed]","DOI":"10.1101\/cshperspect.a016295"},{"key":"e_1_3_1_26_2","doi-asserted-by":"crossref","unstructured":"Hunter CA Jones SA. 2015. IL-6 as a keystone cytokine in health and disease. Nat Immunol 16: 448\u2013457 http:\/\/dx.doi.org\/10.1038\/ni.3153. [PubMed]","DOI":"10.1038\/ni.3153"},{"key":"e_1_3_1_27_2","doi-asserted-by":"crossref","unstructured":"Lin L Ibrahim AS Xu X Farber JM Avanesian V Baquir B Fu Y French SW Edwards JE Jr Spellberg B. 2009. Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog 5: e1000703 http:\/\/dx.doi.org\/10.1371\/journal.ppat.1000703. [PubMed]","DOI":"10.1371\/journal.ppat.1000703"},{"key":"e_1_3_1_28_2","doi-asserted-by":"crossref","unstructured":"Kimura A Kishimoto T. 2010. IL-6: regulator of Treg\/Th17 balance. Eur J Immunol 40: 1830\u20131835 http:\/\/dx.doi.org\/10.1002\/eji.201040391. [PubMed]","DOI":"10.1002\/eji.201040391"},{"key":"e_1_3_1_29_2","doi-asserted-by":"crossref","unstructured":"Smigiel KS Srivastava S Stolley JM Campbell DJ. 2014. Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation. Immunol Rev 259: 40\u201359 http:\/\/dx.doi.org\/10.1111\/imr.12170. [PubMed]","DOI":"10.1111\/imr.12170"},{"key":"e_1_3_1_30_2","doi-asserted-by":"crossref","unstructured":"Lathrop SK Bloom SM Rao SM Nutsch K Lio CW Santacruz N Peterson DA Stappenbeck TS Hsieh CS. 2011. Peripheral education of the immune system by colonic commensal microbiota. Nature 478: 250\u2013254 http:\/\/dx.doi.org\/10.1038\/nature10434. [PubMed]","DOI":"10.1038\/nature10434"},{"key":"e_1_3_1_31_2","doi-asserted-by":"crossref","unstructured":"Bustamante J Boisson-Dupuis S Jouanguy E Picard C Puel A Abel L Casanova JL. 2008. Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases. Curr Opin Immunol 20: 39\u201348 http:\/\/dx.doi.org\/10.1016\/j.coi.2007.10.005. [PubMed]","DOI":"10.1016\/j.coi.2007.10.005"},{"key":"e_1_3_1_32_2","doi-asserted-by":"crossref","unstructured":"Mogensen TH. 2013. STAT3 and the hyper-IgE syndrome: clinical presentation genetic origin pathogenesis novel findings and remaining uncertainties. JAK-STAT 2: e23435 http:\/\/dx.doi.org\/10.4161\/jkst.23435. [PubMed]","DOI":"10.4161\/jkst.23435"},{"key":"e_1_3_1_33_2","doi-asserted-by":"crossref","unstructured":"Heyworth PG Cross AR Curnutte JT. 2003. Chronic granulomatous disease. Curr Opin Immunol 15: 578\u2013584 http:\/\/dx.doi.org\/10.1016\/S0952-7915(03)00109-2.","DOI":"10.1016\/S0952-7915(03)00109-2"},{"key":"e_1_3_1_34_2","doi-asserted-by":"crossref","unstructured":"Choi SM McAleer JP Zheng M Pociask DA Kaplan MH Qin S Reinhart TA Kolls JK. 2013. Innate Stat3-mediated induction of the antimicrobial protein Reg3\u03b3 is required for host defense against MRSA pneumonia. J Exp Med 210: 551\u2013561 http:\/\/dx.doi.org\/10.1084\/jem.20120260. [PubMed]","DOI":"10.1084\/jem.20120260"},{"key":"e_1_3_1_35_2","doi-asserted-by":"crossref","unstructured":"Crum-Cianflone N Weekes J Bavaro M. 2009. Recurrent community-associated methicillin-resistant Staphylococcus aureus infections among HIV-infected persons: incidence and risk factors. AIDS Patient Care STDS 23: 499\u2013502 http:\/\/dx.doi.org\/10.1089\/apc.2008.0240. [PubMed]","DOI":"10.1089\/apc.2008.0240"},{"key":"e_1_3_1_36_2","doi-asserted-by":"crossref","unstructured":"Manfredi R Calza L Chiodo F. 2002. Epidemiology and microbiology of cellulitis and bacterial soft tissue infection during HIV disease: a 10-year survey. J Cutan Pathol 29: 168\u2013172 http:\/\/dx.doi.org\/10.1034\/j.1600-0560.2002.290307.x. [PubMed]","DOI":"10.1034\/j.1600-0560.2002.290307.x"},{"key":"e_1_3_1_37_2","doi-asserted-by":"crossref","unstructured":"Ruiz-Irastorza G Olivares N Ruiz-Arruza I Martinez-Berriotxoa A Egurbide MV Aguirre C. 2009. Predictors of major infections in systemic lupus erythematosus. Arthritis Res Ther 11: R109 http:\/\/dx.doi.org\/10.1186\/ar2764. [PubMed]","DOI":"10.1186\/ar2764"},{"key":"e_1_3_1_38_2","doi-asserted-by":"crossref","unstructured":"Barrera-Vargas A G\u00f3mez-Mart\u00edn D Merayo-Chalico J Ponce-de-Le\u00f3n A Alcocer-Varela J. 2014. Risk factors for drug-resistant bloodstream infections in patients with systemic lupus erythematosus. J Rheumatol 41: 1311\u20131316 http:\/\/dx.doi.org\/10.3899\/jrheum.131261. [PubMed]","DOI":"10.3899\/jrheum.131261"},{"key":"e_1_3_1_39_2","doi-asserted-by":"crossref","unstructured":"Esp\u00edgol-Frigol\u00e9 G Corbera-Bellalta M Planas-Rigol E Lozano E Segarra M Garc\u00eda-Mart\u00ednez A Prieto-Gonz\u00e1lez S Hern\u00e1ndez-Rodr\u00edguez J Grau JM Rahman MU Cid MC. 2013. Increased IL-17A expression in temporal artery lesions is a predictor of sustained response to glucocorticoid treatment in patients with giant-cell arteritis. Ann Rheum Dis 72: 1481\u20131487 http:\/\/dx.doi.org\/10.1136\/annrheumdis-2012-201836. [PubMed]","DOI":"10.1136\/annrheumdis-2012-201836"},{"key":"e_1_3_1_40_2","doi-asserted-by":"crossref","unstructured":"Taylor AL Llewelyn MJ Rudak PT Memarnejadian A Szabo PA Tun-Abraham ME Rossjohn J Corbett AJ McCluskey J McCormick JK Lantz O Hernandez-Alejandro R Taylor AL Llewelyn MJ. 2010. Superantigen-induced proliferation of human CD4+CD25- T cells is followed by a switch to a functional regulatory phenotype. J Immunol 185: 6591\u20136598 http:\/\/dx.doi.org\/10.4049\/jimmunol.1002416. [PubMed]","DOI":"10.4049\/jimmunol.1002416"},{"key":"e_1_3_1_41_2","doi-asserted-by":"crossref","unstructured":"Ussher JE Klenerman P Willberg CB. 2014. Mucosal-associated invariant T-cells: new players in anti-bacterial immunity. Front Immunol 5: 450 http:\/\/dx.doi.org\/10.3389\/fimmu.2014.00450. [PubMed]","DOI":"10.3389\/fimmu.2014.00450"},{"key":"e_1_3_1_42_2","doi-asserted-by":"crossref","unstructured":"Gao Y Williams AP. 2015. Role of innate T cells in anti-bacterial immunity. Front Immunol 2: 302. [PubMed]","DOI":"10.3389\/fimmu.2015.00302"},{"key":"e_1_3_1_43_2","doi-asserted-by":"crossref","unstructured":"Napier RJ Adams EJ Gold MC Lewinsohn DM. 2015. The role of mucosal associated Invariant T cells in antimicrobial immunity. Front Immunol 6: 344 http:\/\/dx.doi.org\/10.3389\/fimmu.2015.00344. [PubMed]","DOI":"10.3389\/fimmu.2015.00344"},{"key":"e_1_3_1_44_2","doi-asserted-by":"crossref","unstructured":"Sandberg JK Norrby-Teglund A Leeansyah E. 2017. Bacterial deception of MAIT cells in a cloud of superantigen and cytokines. PLoS Biol 15: e2003167 http:\/\/dx.doi.org\/10.1371\/journal.pbio.2003167. [PubMed]","DOI":"10.1371\/journal.pbio.2003167"},{"key":"e_1_3_1_45_2","doi-asserted-by":"crossref","unstructured":"Xiao X Cai J. 2017. Mucosal-associated invariant T cells: new insights into antigen recognition and activation. Front Immunol 8: 1540 http:\/\/dx.doi.org\/10.3389\/fimmu.2017.01540. [PubMed]","DOI":"10.3389\/fimmu.2017.01540"},{"key":"e_1_3_1_46_2","unstructured":"Reantragoon R Boonpattanaporn N Corbett AJ McCluskey J. 2016. Mucosal-associated invariant T cells in clinical diseases. Asian Pac J Allergy Immunol 34: 3\u201310."},{"key":"e_1_3_1_47_2","doi-asserted-by":"crossref","unstructured":"Grimaldi D Le Bourhis L Sauneuf B Dechartres A Rousseau C Ouaaz F Milder M Louis D Chiche JD Mira JP Lantz O P\u00e8ne F. 2014. Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections. Intensive Care Med 40: 192\u2013201 http:\/\/dx.doi.org\/10.1007\/s00134-013-3163-x. [PubMed]","DOI":"10.1007\/s00134-013-3163-x"},{"key":"e_1_3_1_48_2","doi-asserted-by":"crossref","unstructured":"Shaler CR Choi J Rudak PT Memarnejadian A Szabo PA Tun-Abraham ME Rossjohn J Corbett AJ McCluskey J McCormick JK Lantz O Hernandez-Alejandro R Haeryfar SMM. 2017. MAIT cells launch a rapid robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: defining a novel mechanism of superantigen-induced immunopathology and immunosuppression. PLoS Biol 15: e2001930 http:\/\/dx.doi.org\/10.1371\/journal.pbio.2001930. [PubMed]","DOI":"10.1371\/journal.pbio.2001930"},{"key":"e_1_3_1_49_2","doi-asserted-by":"crossref","unstructured":"Balkhi MY Ma Q Ahmad S Junghans RP. 2015. T cell exhaustion and interleukin 2 downregulation. Cytokine 71: 339\u2013347 http:\/\/dx.doi.org\/10.1016\/j.cyto.2014.11.024. [PubMed]","DOI":"10.1016\/j.cyto.2014.11.024"},{"key":"e_1_3_1_50_2","doi-asserted-by":"crossref","unstructured":"Dusseaux M Martin E Serriari N P\u00e9guillet I Premel V Louis D Milder M Le Bourhis L Soudais C Treiner E Lantz O. 2011. Human MAIT cells are xenobiotic-resistant tissue-targeted CD161hi IL-17-secreting T cells. Blood 117: 1250\u20131259 http:\/\/dx.doi.org\/10.1182\/blood-2010-08-303339. [PubMed]","DOI":"10.1182\/blood-2010-08-303339"},{"key":"e_1_3_1_51_2","doi-asserted-by":"crossref","unstructured":"Lussow AR MacDonald HR. 1994. Differential effects of superantigen-induced \u201canergy\u201d on priming and effector stages of a T cell-dependent antibody response. Eur J Immunol 24: 445\u2013449 http:\/\/dx.doi.org\/10.1002\/eji.1830240227. [PubMed]","DOI":"10.1002\/eji.1830240227"},{"key":"e_1_3_1_52_2","doi-asserted-by":"crossref","unstructured":"White J Herman A Pullen AM Kubo R Kappler JW Marrack P. 1989. The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56: 27\u201335 http:\/\/dx.doi.org\/10.1016\/0092-8674(89)90980-X.","DOI":"10.1016\/0092-8674(89)90980-X"},{"key":"e_1_3_1_53_2","doi-asserted-by":"crossref","unstructured":"Ramesh N Horner A Ahern D Geha RS. 1995. Bacterial superantigens induce the proliferation of resting gamma\/delta receptor bearing T cells. Immunol Invest 24: 713\u2013724 http:\/\/dx.doi.org\/10.3109\/08820139509060700. [PubMed]","DOI":"10.3109\/08820139509060700"},{"key":"e_1_3_1_54_2","doi-asserted-by":"crossref","unstructured":"Cho SN Song CH Jin J Kim SH Rha KS Kim YM. 2014. Role of staphylococcal enterotoxin B on the differentiation of regulatory T cells in nasal polyposis. Am J Rhinol Allergy 28: e17\u2013e24 http:\/\/dx.doi.org\/10.2500\/ajra.2014.28.3995. [PubMed]","DOI":"10.2500\/ajra.2014.28.3995"},{"key":"e_1_3_1_55_2","doi-asserted-by":"crossref","unstructured":"Gagliani N Amezcua Vesely MC Iseppon A Brockmann L Xu H Palm NW de Zoete MR Licona-Lim\u00f3n P Paiva RS Ching T Weaver C Zi X Pan X Fan R Garmire LX Cotton MJ Drier Y Bernstein B Geginat J Stockinger B Esplugues E Huber S Flavell RA. 2015. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature 523: 221\u2013225 http:\/\/dx.doi.org\/10.1038\/nature14452. [PubMed]","DOI":"10.1038\/nature14452"},{"key":"e_1_3_1_56_2","doi-asserted-by":"crossref","unstructured":"Ouyang W Liao W Luo CT Yin N Huse M Kim MV Peng M Chan P Ma Q Mo Y Meijer D Zhao K Rudensky AY Atwal G Zhang MQ Li MO. 2012. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature 491: 554\u2013559 http:\/\/dx.doi.org\/10.1038\/nature11581. [PubMed]","DOI":"10.1038\/nature11581"},{"key":"e_1_3_1_57_2","doi-asserted-by":"crossref","unstructured":"Pandiyan P Zhu J. 2015. Origin and function of pro-inflammaory regulatory T cells. Cytokine 76: 13\u201324 http:\/\/dx.doi.org\/10.1016\/j.cyto.2015.07.005. [PubMed]","DOI":"10.1016\/j.cyto.2015.07.005"},{"key":"e_1_3_1_58_2","doi-asserted-by":"crossref","unstructured":"Zeng WP McFarland MM Zhou B Holtfreter S Flesher S Cheung A Mallick A. 2017. Staphylococcal enterotoxin A-activated regulatory T cells promote allergen-specific T H 2 response to intratracheal allergen inoculation. J Allergy Clin Immunol 139: 508\u2013518.e4 http:\/\/dx.doi.org\/10.1016\/j.jaci.2016.04.033. [PubMed]","DOI":"10.1016\/j.jaci.2016.04.033"},{"key":"e_1_3_1_59_2","doi-asserted-by":"crossref","unstructured":"Fritz SA Tiemann KM Hogan PG Epplin EK Rodriguez M Al-Zubeidi DN Bubeck Wardenburg J Hunstad DA. 2013. A serologic correlate of protective immunity against community-onset Staphylococcus aureus infection. Clin Infect Dis 56: 1554\u20131561 http:\/\/dx.doi.org\/10.1093\/cid\/cit123. [PubMed]","DOI":"10.1093\/cid\/cit123"},{"key":"e_1_3_1_60_2","doi-asserted-by":"crossref","unstructured":"Seok J Warren HS Cuenca AG Mindrinos MN Baker HV Xu W Richards DR McDonald-Smith GP Gao H Hennessy L Finnerty CC L\u00f3pez CM Honari S Moore EE Minei JP Cuschieri J Bankey PE Johnson JL Sperry J Nathens AB Billiar TR West MA Jeschke MG Klein MB Gamelli RL Gibran NS Brownstein BH Miller-Graziano C Calvano SE Mason PH Cobb JP Rahme LG Lowry SF Maier RV Moldawer LL Herndon DN Davis RW Xiao W Tompkins RG. 2013. In ammation and host response to injury large scale collaborative research program. Genomic responses in mouse models poorly mimic human in ammatory diseases. Proc Natl Acad Sci U S A 110: 3507\u20133512 http:\/\/dx.doi.org\/10.1073\/pnas.1222878110. [PubMed]","DOI":"10.1073\/pnas.1222878110"},{"key":"e_1_3_1_61_2","doi-asserted-by":"crossref","unstructured":"Spaulding AR Lin YC Merriman JA Brosnahan AJ Peterson ML Schlievert PM. 2012. Immunity to Staphylococcus aureus secreted proteins protects rabbits from serious illnesses. Vaccine 30: 5099\u20135109 http:\/\/dx.doi.org\/10.1016\/j.vaccine.2012.05.067. [PubMed]","DOI":"10.1016\/j.vaccine.2012.05.067"},{"key":"e_1_3_1_62_2","doi-asserted-by":"crossref","unstructured":"Rasigade JP Sicot N Laurent F Lina G Vandenesch F Etienne J. 2011. A history of Panton-Valentine leukocidin (PVL)-associated infection protects against death in PVL-associated pneumonia. Vaccine 29: 4185\u20134186 http:\/\/dx.doi.org\/10.1016\/j.vaccine.2011.04.033. [PubMed]","DOI":"10.1016\/j.vaccine.2011.04.033"},{"key":"e_1_3_1_63_2","doi-asserted-by":"crossref","unstructured":"Fowler VG Allen KB Moreira ED Moustafa M Isgro F Boucher HW Corey GR Carmeli Y Betts R Hartzel JS Chan ISF McNeely TB Kartsonis NA Guris D Onorato MT Smugar SS DiNubile MJ Sobanjo-ter Meulen A. 2013. Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery. JAMA 309: 1368\u20131378 http:\/\/dx.doi.org\/10.1001\/jama.2013.3010. [PubMed]","DOI":"10.1001\/jama.2013.3010"},{"key":"e_1_3_1_64_2","doi-asserted-by":"crossref","unstructured":"McNeely TB Shah NA Fridman A Joshi A Hartzel JS Keshari RS Lupu F DiNubile MJ. 2014. Mortality among recipients of the Merck V710 Staphylococcus aureus vaccine after postoperative S. aureus infections: an analysis of possible contributing host factors. Hum Vaccin Immunother 10: 3513\u20133516 http:\/\/dx.doi.org\/10.4161\/hv.34407. [PubMed]","DOI":"10.4161\/hv.34407"},{"key":"e_1_3_1_65_2","doi-asserted-by":"crossref","unstructured":"Humrich JY Riemekasten G. 2016. Restoring regulation: IL-2 therapy in systemic lupus erythematosus. Expert Rev Clin Immunol 12: 1153\u20131160 http:\/\/dx.doi.org\/10.1080\/1744666X.2016.1199957. [PubMed]","DOI":"10.1080\/1744666X.2016.1199957"},{"key":"e_1_3_1_66_2","doi-asserted-by":"crossref","unstructured":"Gupta DL Bhoi S Mohan T Galwnkar S Rao DN. 2016. Coexistence of Th1\/Th2 and Th17\/Treg imbalances in patients with post traumatic sepsis. Cytokine 88: 214\u2013221 http:\/\/dx.doi.org\/10.1016\/j.cyto.2016.09.010. [PubMed]","DOI":"10.1016\/j.cyto.2016.09.010"},{"key":"e_1_3_1_67_2","doi-asserted-by":"crossref","unstructured":"Minejima E Bensman J She RC Mack WJ Tuan Tran M Ny P Lou M Yamaki J Nieberg P Ho J Wong-Beringer A. 2016. A dysregulated balance of proinflammatory and anti-inflammatory host cytokine response early during therapy predicts persistence and mortality in Staphylococcus aureus bacteremia. Crit Care Med 44: 671\u2013679. [PubMed]","DOI":"10.1097\/CCM.0000000000001465"},{"key":"e_1_3_1_68_2","doi-asserted-by":"crossref","unstructured":"van Dissel JT van Langevelde P Westendorp RG Kwappenberg K Fr\u00f6lich M. 1998. Anti-inflammatory cytokine profile and mortality in febrile patients. Lancet 351: 950\u2013953 http:\/\/dx.doi.org\/10.1016\/S0140-6736(05)60606-X.","DOI":"10.1016\/S0140-6736(05)60606-X"},{"key":"e_1_3_1_69_2","doi-asserted-by":"crossref","unstructured":"Rose WE Eickhoff JC Shukla SK Pantrangi M Rooijakkers S Cosgrove SE Nizet V Sakoulas G. 2012. Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia. J Infect Dis 206: 1604\u20131611 http:\/\/dx.doi.org\/10.1093\/infdis\/jis552. [PubMed]","DOI":"10.1093\/infdis\/jis552"},{"key":"e_1_3_1_70_2","doi-asserted-by":"crossref","unstructured":"Rose WE Shukla SK Berti AD Hayney MS Henriquez KM Ranzoni A Cooper MA Proctor RA Nizet V Sakoulas G. 2017. Increased endovascular Staphylococcus aureus inoculum is the link between elevated serum interleukin 10 concentrations and mortality in patients with bacteremia. Clin Infect Dis 64: 1406\u20131412 http:\/\/dx.doi.org\/10.1093\/cid\/cix157. [PubMed]","DOI":"10.1093\/cid\/cix157"},{"key":"e_1_3_1_71_2","doi-asserted-by":"crossref","unstructured":"Zielinski CE Mele F Aschenbrenner D Jarrossay D Ronchi F Gattorno M Monticelli S Lanzavecchia A Sallusto F. 2012. Pathogen-induced human TH17 cells produce IFN-\u03b3 or IL-10 and are regulated by IL-1\u03b2. Nature 484: 514\u2013518 http:\/\/dx.doi.org\/10.1038\/nature10957. [PubMed]","DOI":"10.1038\/nature10957"},{"key":"e_1_3_1_72_2","doi-asserted-by":"crossref","unstructured":"Crisp\u00edn JC Tsokos GC. 2009. Transcriptional regulation of IL-2 in health and autoimmunity. Autoimmun Rev 8: 190\u2013195 http:\/\/dx.doi.org\/10.1016\/j.autrev.2008.07.042. [PubMed]","DOI":"10.1016\/j.autrev.2008.07.042"},{"key":"e_1_3_1_73_2","unstructured":"Boyman O Kolios AG Raeber ME. 2015. Modulation of T cell responses by IL-2 and IL-2 complexes. Clin Exp Rheumatol 33 (Suppl 92) : S54\u2013S57."},{"key":"e_1_3_1_74_2","doi-asserted-by":"crossref","unstructured":"Chapman NM Bilal MY Cruz-Orcutt N Knudson C Madinaveitia S Light J Houtman JC. 2013. Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells. Cell Signal 25: 639\u2013650 http:\/\/dx.doi.org\/10.1016\/j.cellsig.2012.11.026. [PubMed]","DOI":"10.1016\/j.cellsig.2012.11.026"},{"key":"e_1_3_1_75_2","doi-asserted-by":"crossref","unstructured":"Chau TA McCully ML Brintnell W An G Kasper KJ Vin\u00e9s ED Kubes P Haeryfar SM McCormick JK Cairns E Heinrichs DE Madrenas J. 2009. Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nat Med 15: 641\u2013648 http:\/\/dx.doi.org\/10.1038\/nm.1965. [PubMed]","DOI":"10.1038\/nm.1965"},{"key":"e_1_3_1_76_2","doi-asserted-by":"crossref","unstructured":"Li Z Levast B Madrenas J. 2017. Staphylococcus aureus downregulates IP-10 production and prevents Th1 cell recruitment. J Immunol 198: 1865\u20131874 http:\/\/dx.doi.org\/10.4049\/jimmunol.1601336. [PubMed]","DOI":"10.4049\/jimmunol.1601336"},{"key":"e_1_3_1_77_2","doi-asserted-by":"crossref","unstructured":"Li Z Peres AG Damian AC Madrenas J. 2015. Immunomodulation and disease tolerance to Staphylococcus aureus . Pathogens 4: 793\u2013815 http:\/\/dx.doi.org\/10.3390\/pathogens4040793. [PubMed]","DOI":"10.3390\/pathogens4040793"},{"key":"e_1_3_1_78_2","doi-asserted-by":"crossref","unstructured":"Andrade EB Alves J Madureira P Oliveira L Ribeiro A Cordeiro-da-Silva A Correia-Neves M Trieu-Cuot P Ferreira P. 2013. TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis. J Immunol 191: 4759\u20134768 http:\/\/dx.doi.org\/10.4049\/jimmunol.1301752. [PubMed]","DOI":"10.4049\/jimmunol.1301752"},{"key":"e_1_3_1_79_2","doi-asserted-by":"crossref","unstructured":"Leech JM Lacey KA Mulcahy ME Medina E McLoughlin RM. 2017. IL-10 plays opposing roles during Staphylococcus aureus systemic and localized infections. J Immunol 198: 2352\u20132365 http:\/\/dx.doi.org\/10.4049\/jimmunol.1601018. [PubMed]","DOI":"10.4049\/jimmunol.1601018"},{"key":"e_1_3_1_80_2","doi-asserted-by":"crossref","unstructured":"Martire-Greco D Rodriguez-Rodrigues N Landoni VI Rearte B Isturiz MA Fern\u00e1ndez GC. 2013. Interleukin-10 controls human peripheral PMN activation triggered by lipopolysaccharide. Cytokine 62: 426\u2013432 http:\/\/dx.doi.org\/10.1016\/j.cyto.2013.03.025. [PubMed]","DOI":"10.1016\/j.cyto.2013.03.025"},{"key":"e_1_3_1_81_2","doi-asserted-by":"crossref","unstructured":"Shibata Y Foster LA Kurimoto M Okamura H Nakamura RM Kawajiri K Justice JP Van Scott MR Myrvik QN Metzger WJ. 1998. Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-gamma-inducing factors but enhances NK cell production of IFN-gamma. J Immunol 161: 4283\u20134288.","DOI":"10.4049\/jimmunol.161.8.4283"},{"key":"e_1_3_1_82_2","doi-asserted-by":"crossref","unstructured":"Wang JE J\u00f8rgensen PF Alml\u00f6f M Thiemermann C Foster SJ Aasen AO Solberg R. 2000. Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha interleukin 6 (IL-6) and IL-10 production in both T cells and monocytes in a human whole blood model. Infect Immun 68: 3965\u20133970 http:\/\/dx.doi.org\/10.1128\/IAI.68.7.3965-3970.2000. [PubMed]","DOI":"10.1128\/IAI.68.7.3965-3970.2000"},{"key":"e_1_3_1_83_2","doi-asserted-by":"crossref","unstructured":"Brown AF Leech JM Rogers TR McLoughlin RM. 2014. Staphylococcus aureus colonization: modulation of host immune response and impact on human vaccine design. Front Immunol 4: 507 http:\/\/dx.doi.org\/10.3389\/fimmu.2013.00507. [PubMed]","DOI":"10.3389\/fimmu.2013.00507"},{"key":"e_1_3_1_84_2","doi-asserted-by":"crossref","unstructured":"Brown AF Murphy AG Lalor SJ Leech JM O\u2019Keeffe KM Mac Aog\u00e1in M O\u2019Halloran DP Lacey KA Tavakol M Hearnden CH Fitzgerald-Hughes D Humphreys H Fennell JP van Wamel WJ Foster TJ Geoghegan JA Lavelle EC Rogers TR McLoughlin RM. 2015. Memory Th1 cells are protective in invasive Staphylococcus aureus infection. PLoS Pathog 11: e1005226 http:\/\/dx.doi.org\/10.1371\/journal.ppat.1005226. [PubMed]","DOI":"10.1371\/journal.ppat.1005226"},{"key":"e_1_3_1_85_2","doi-asserted-by":"crossref","unstructured":"S\u00f6derquist B Sundqvist KG Vikerfors T. 1992. Kinetics of serum levels of interleukin-6 in Staphylococcus aureus septicemia. Scand J Infect Dis 24: 607\u2013612 http:\/\/dx.doi.org\/10.3109\/00365549209054646. [PubMed]","DOI":"10.3109\/00365549209054646"},{"key":"e_1_3_1_86_2","doi-asserted-by":"crossref","unstructured":"McNicholas S Talento AF O\u2019Gorman J Hannan MM Lynch M Greene CM Humphreys H Fitzgerald-Hughes D. 2014. Cytokine responses to Staphylococcus aureus bloodstream infection differ between patient cohorts that have different clinical courses of infection. BMC Infect Dis 14: 580 http:\/\/dx.doi.org\/10.1186\/s12879-014-0580-6. [PubMed]","DOI":"10.1186\/s12879-014-0580-6"},{"key":"e_1_3_1_87_2","doi-asserted-by":"crossref","unstructured":"Chantratita N Tandhavanant S Seal S Wikraiphat C Wongsuvan G Ariyaprasert P Suntornsut P Teerawattanasook N Jutrakul Y Srisurat N Chaimanee P Mahavanakul W Srisamang P Phiphitaporn S Mokchai M Anukunananchai J Wongratanacheewin S Chetchotisakd P Emond MJ Peacock SJ West TE. 2017. TLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis. Clin Microbiol Infect 23: 47.e1\u201347.e10 http:\/\/dx.doi.org\/10.1016\/j.cmi.2016.08.028. [PubMed]","DOI":"10.1016\/j.cmi.2016.08.028"},{"key":"e_1_3_1_88_2","doi-asserted-by":"crossref","unstructured":"Jin JO Zhang W Du JY Yu Q. 2014. BDCA1-positive dendritic cells (DCs) represent a unique human myeloid DC subset that induces innate and adaptive immune responses to Staphylococcus aureus infection. Infect Immun 82: 4466\u20134476 http:\/\/dx.doi.org\/10.1128\/IAI.01851-14. [PubMed]","DOI":"10.1128\/IAI.01851-14"},{"key":"e_1_3_1_89_2","doi-asserted-by":"crossref","unstructured":"Karauzum H Haudenschild CC Moore IN Mahmoudieh M Barber DL Datta SK. 2017. Lethal CD4 T cell responses induced by vaccination against Staphylococcus aureus bacteremia. J Infect Dis 215: 1231\u20131239 http:\/\/dx.doi.org\/10.1093\/infdis\/jix096. [PubMed]","DOI":"10.1093\/infdis\/jix096"},{"key":"e_1_3_1_90_2","doi-asserted-by":"crossref","unstructured":"Koymans KJ Feitsma LJ Brondijk TH Aerts PC Lukkien E L\u00f6ssl P van Kessel KP de Haas CJ van Strijp JA Huizinga EG. 2015. Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3). Proc Natl Acad Sci U S A 112: 11018\u201311023 http:\/\/dx.doi.org\/10.1073\/pnas.1502026112. [PubMed]","DOI":"10.1073\/pnas.1502026112"},{"key":"e_1_3_1_91_2","doi-asserted-by":"crossref","unstructured":"Koymans KJ Vrieling M Gorham RD Jr van Strijp JAG. 2017. Staphylococcal immune evasion proteins: structure function and host adaptation. Curr Top Microbiol Immunol 409: 441\u2013489 http:\/\/dx.doi.org\/10.1007\/82_2015_5017. [PubMed]","DOI":"10.1007\/82_2015_5017"},{"key":"e_1_3_1_92_2","doi-asserted-by":"crossref","unstructured":"Nagelkerken L Gollob KJ Tielemans M Coffman RL. 1993. Role of transforming growth factor-beta in the preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B. Eur J Immunol 23: 2306\u20132310 http:\/\/dx.doi.org\/10.1002\/eji.1830230938. [PubMed]","DOI":"10.1002\/eji.1830230938"},{"key":"e_1_3_1_93_2","doi-asserted-by":"crossref","unstructured":"Niedergang F H\u00e9mar A Hewitt CR Owen MJ Dautry-Varsat A Alcover A. 1995. The Staphylococcus aureus enterotoxin B superantigen induces specific T cell receptor down-regulation by increasing its internalization. J Biol Chem 270: 12839\u201312845 http:\/\/dx.doi.org\/10.1074\/jbc.270.21.12839. [PubMed]","DOI":"10.1074\/jbc.270.21.12839"},{"key":"e_1_3_1_94_2","doi-asserted-by":"crossref","unstructured":"Stach CS Herrera A Schlievert PM. 2014. Staphylococcal superantigens interact with multiple host receptors to cause serious diseases. Immunol Res 59: 177\u2013181 http:\/\/dx.doi.org\/10.1007\/s12026-014-8539-7. [PubMed]","DOI":"10.1007\/s12026-014-8539-7"},{"key":"e_1_3_1_95_2","doi-asserted-by":"crossref","unstructured":"Szabo PA Goswami A Mazzuca DM Kim K O\u2019Gorman DB Hess DA Welch ID Young HA Singh B McCormick JK Haeryfar SM. 2017. Rapid and rigorous IL-17A production by a distinct subpopulation of effector memory T lymphocytes constitutes a novel mechanism of toxic shock syndrome immunopathology. J Immunol 198: 2805\u20132818 http:\/\/dx.doi.org\/10.4049\/jimmunol.1601366. [PubMed]","DOI":"10.4049\/jimmunol.1601366"},{"key":"e_1_3_1_96_2","doi-asserted-by":"crossref","unstructured":"Takahashi N Hasegawa H Komiyama M Ohki T Yada Y Koike Y Kawamata R Honma Y Momoi M. 2009. Selective excretion of anti-inflammatory cytokine interleukin-10 in a superantigen-inducing neonatal infectious disease. Cytokine 45: 39\u201343 http:\/\/dx.doi.org\/10.1016\/j.cyto.2008.10.015. [PubMed]","DOI":"10.1016\/j.cyto.2008.10.015"},{"key":"e_1_3_1_97_2","doi-asserted-by":"crossref","unstructured":"Tuffs SW James DBA Bestebroer J Richards AC Goncheva MI O\u2019Shea M Wee BA Seo KS Schlievert PM Lengeling A van Strijp JA Torres VJ Fitzgerald JR. 2017. The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function. PLoS Pathog 13: e1006461 http:\/\/dx.doi.org\/10.1371\/journal.ppat.1006461. [PubMed]","DOI":"10.1371\/journal.ppat.1006461"},{"key":"e_1_3_1_98_2","doi-asserted-by":"crossref","unstructured":"Stolz SJ Davis JP Vergeront JM Crass BA Chesney PJ Wand PJ Bergdoll MS. 1985. Development of serum antibody to toxic shock toxin among individuals with toxic shock syndrome in Wisconsin. J Infect Dis 151: 883\u2013889 http:\/\/dx.doi.org\/10.1093\/infdis\/151.5.883. [PubMed]","DOI":"10.1093\/infdis\/151.5.883"},{"key":"e_1_3_1_99_2","doi-asserted-by":"crossref","unstructured":"Iwakura Y Ishigame H Saijo S Nakae S. 2011. Functional specialization of interleukin-17 family members. Immunity 34: 149\u2013162 http:\/\/dx.doi.org\/10.1016\/j.immuni.2011.02.012. [PubMed]","DOI":"10.1016\/j.immuni.2011.02.012"},{"key":"e_1_3_1_100_2","unstructured":"Iwasaka H Noguchi T. 2004. Th1\/Th2 balance in systemic inflammatory response syndrome (SIRS). Nihon Rinsho 62: 2237\u20132243. (In Japanese.)"},{"key":"e_1_3_1_101_2","doi-asserted-by":"crossref","unstructured":"Lacey KA Geoghegan JA McLoughlin RM. 2016. The role of Staphylococcus aureus virulence factors in skin infection and their potential as vaccine antigens. Pathogens 17: E22. [PubMed]","DOI":"10.3390\/pathogens5010022"},{"key":"e_1_3_1_102_2","doi-asserted-by":"crossref","unstructured":"Frodermann V Chau TA Sayedyahossein S Toth JM Heinrichs DE Madrenas J. 2011. A modulatory interleukin-10 response to staphylococcal peptidoglycan prevents Th1\/Th17 adaptive immunity to Staphylococcus aureus . J Infect Dis 204: 253\u2013262 http:\/\/dx.doi.org\/10.1093\/infdis\/jir276. [PubMed]","DOI":"10.1093\/infdis\/jir276"},{"key":"e_1_3_1_103_2","doi-asserted-by":"crossref","unstructured":"Donabedian H Gallin JI. 1983. The hyperimmunoglobulin E recurrent-infection (Job\u2019s) syndrome. A review of the NIH experience and the literature. Medicine (Baltimore) 62: 195\u2013208 http:\/\/dx.doi.org\/10.1097\/00005792-198307000-00001. [PubMed]","DOI":"10.1097\/00005792-198307000-00001"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/microbiolspec.GPP3-0037-2018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/microbiolspec.GPP3-0037-2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:44:59Z","timestamp":1695019499000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/microbiolspec.GPP3-0037-2018"}},"subtitle":[],"editor":[{"given":"Vincent A.","family":"Fischetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Richard P.","family":"Novick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Joseph J.","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Daniel A.","family":"Portnoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Miriam","family":"Braunstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Julian I.","family":"Rood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,7,19]]},"references-count":102,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7,19]]}},"alternative-id":["10.1128\/microbiolspec.GPP3-0037-2018"],"URL":"https:\/\/doi.org\/10.1128\/microbiolspec.gpp3-0037-2018","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,19]]},"assertion":[{"value":"2018-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7.4.8"}}