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In recent decades, the treatment of staphylococcal infections has become increasingly difficult as the prevalence of multi-drug resistant strains continues to rise. With increasing mortality rates and medical costs associated with drug resistant strains, there is an urgent need for alternative therapeutic options. Many innovative strategies for alternative drug development are being pursued, including disruption of biofilms, inhibition of virulence factor production, bacteriophage-derived antimicrobials, anti-staphylococcal vaccines, and light-based therapies. While many compounds and methods still need further study to determine their feasibility, some are quickly approaching clinical application and may be available in the near future.\n                  <\/jats:p>","DOI":"10.1128\/microbiolspec.gpp3-0047-2018","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T07:49:25Z","timestamp":1544773765000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Nonconventional Therapeutics against\n                    <i>Staphylococcus aureus<\/i>"],"prefix":"10.1128","volume":"6","author":[{"given":"Caroline M.","family":"Grunenwald","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232"},{"name":"Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique R.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Graduate Program in Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric P.","family":"Skaar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232"},{"name":"Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","unstructured":"Kirby WM. 1944. 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