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During each stage of the enzootic cycle,\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    is exposed to environments that differ in temperature, pH, small molecules, and most important, nutrient sources.\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    has a highly restricted metabolic capacity because it does not contain a tricarboxylic acid cycle, oxidative phosphorylation, or any pathways for\n                    <jats:italic>de novo<\/jats:italic>\n                    biosynthesis of carbohydrates, amino acids, or lipids. Thus,\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    relies solely on glycolysis for ATP production and is completely dependent on the transport of nutrients and cofactors from extracellular sources. Herein, pathways for carbohydrate uptake and utilization in\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    are described. Regulation of these pathways during the different phases of the enzootic cycle is discussed. In addition, a model for differential control of nutrient flux through the glycolytic pathway as the spirochete transits through the enzootic cycle is presented.\n                  <\/jats:p>","DOI":"10.1128\/microbiolspec.mbp-0011-2014","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T08:01:30Z","timestamp":1435305690000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["<i>Borrelia burgdorferi<\/i>\n                    : Carbon Metabolism and the Tick-Mammal Enzootic Cycle"],"prefix":"10.1128","volume":"3","author":[{"given":"Arianna","family":"Corona","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, New York Medical College, Valhalla, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, New York Medical College, Valhalla, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Bacon RM Kugeler KJ Mead PS. 2008. 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