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Type V secretion systems (T5SS) use \u03b2-barrel transporter domains to export passenger domains across the outer membranes of Gram-negative bacteria. Distinct among T5SS are type Vb or two-partner secretion (TPS) systems in which the transporter and passenger are separate proteins, necessitating a mechanism for passenger-translocator recognition in the periplasm and providing the potential for reuse of the translocator. This review describes current knowledge of the TPS translocation mechanism, using<jats:italic>Bordetella<\/jats:italic>filamentous hemagglutinin (FHA) and its transporter FhaC as a model. We present the hypothesis that the TPS pathway may be a general mechanism for contact-dependent delivery of toxins to target cells.<\/jats:p>","DOI":"10.1128\/microbiolspec.psib-0024-2018","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T12:45:18Z","timestamp":1553949918000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["<i>Bordetella<\/i>Filamentous Hemagglutinin, a Model for the Two-Partner Secretion Pathway"],"prefix":"10.1128","volume":"7","author":[{"given":"Zachary M.","family":"Nash","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina\u2014Chapel Hill, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy A.","family":"Cotter","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina\u2014Chapel Hill, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","unstructured":"Leo JC Grin I Linke D. 2012. 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