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Most\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    species, including\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    , have long been thought to be \u201cimperfect\u201d due to the lack of a complete sexual reproduction cycle. Since the discovery of the mating type-like locus in\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    in 1999, the regulation of (para)sexual reproduction has been intensively investigated in this organism as well as in several phylogenetically closely related species. The (para)sexual cycle is not only critical for the generation of genetic and phenotypic diversity but is also involved in the regulation of other biological processes, such as morphological transitions, biofilm development, and virulence in pathogenic fungi. In this review article, we focus on the unique characteristics and genetic and environmental regulatory mechanisms of parasexual reproduction in the pathogenic\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    species. We discuss the relationship between the white-opaque switching and mating in the\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    species, particularly in\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    . We describe recent findings on environmental factors, genetic regulators, and key signaling pathways involved in sexual mating in\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    and related species. Finally, we discuss the mating potential and associated regulatory machinery in several\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    species, where parasexual reproduction has not been observed and bring to light some open-ended questions regarding the unique features of parasexual reproduction that should be addressed in future studies in the field.\n                  <\/jats:p>","DOI":"10.1128\/mmbr.00002-25","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:00:28Z","timestamp":1759323628000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Genetic and environmental control of parasexual reproduction in the pathogenic\n                    <i>Candida<\/i>\n                    species"],"prefix":"10.1128","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6814-6338","authenticated-orcid":true,"given":"Chengjun","family":"Cao","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00ydy7x73","id-type":"ROR","asserted-by":"publisher"}],"name":"College of Pharmaceutical Sciences, Southwest University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-3480","authenticated-orcid":true,"given":"Li","family":"Tao","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Infectious Disease and Biosecurity, Department of Infectious Diseases, Huashan Hospital, and State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Fudan University","place":["Shanghai, 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School of Medicine, Tongji University","place":["Shanghai, China"]},{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin M.","family":"Perry","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00d9ah105","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular and Cell Biology, University of California, Merced","place":["Merced, USA"]},{"id":[{"id":"https:\/\/ror.org\/00d9ah105","id-type":"ROR","asserted-by":"publisher"}],"name":"Quantitative and Systems Biology Graduate Program, University of California, Merced","place":["Merced, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-6499","authenticated-orcid":true,"given":"Clarissa 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