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Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in the treatment of emerging infections and noninfective diseases. Procedures for in vivo and in vitro genetic manipulations in<jats:italic>S. rimosus<\/jats:italic>have been developed since the 1950s and applied to study the genetic instability of<jats:italic>S. rimosus<\/jats:italic>strains and for the molecular cloning and characterization of genes involved in oxytetracycline biosynthesis. Recent advances in the methodology of genome sequencing bring the realistic prospect of obtaining the genome sequence of<jats:italic>S. rimosus<\/jats:italic>in the near term.<\/jats:p><\/jats:sec>","DOI":"10.1128\/mmbr.00004-06","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T19:08:22Z","timestamp":1157656102000},"page":"704-728","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":96,"title":["Genetics of<i>Streptomyces rimosus<\/i>, the Oxytetracycline Producer"],"prefix":"10.1128","volume":"70","author":[{"given":"Hrvoje","family":"Petkovic\u0301","sequence":"first","affiliation":[{"name":"Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Cullum","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Kaiserslautern, Kaiserslautern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daslav","family":"Hranueli","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain S.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Royal College, University of Strathclyde, Glasgow, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natas\u030ca","family":"Peric\u0301-Concha","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of London, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasenka","family":"Pigac","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ru\u00f0er Bos\u030ckovic\u0301 Institute, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arinthip","family":"Thamchaipenet","sequence":"additional","affiliation":[{"name":"Faculty of Science, Kasetsart University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dus\u030cica","family":"Vujaklija","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ru\u00f0er Bos\u030ckovic\u0301 Institute, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Long","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of London, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"13","volume":"1","year":"1987","unstructured":"Ackermann, H.-W., and M. 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