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The high prevalence of associated morbidity and mortality, together with an increased emergence of multidrug-resistant strains, is a current global health issue that has prompted the development of vaccination strategies that confer protection against most serovars. Currently available systemic vaccine approaches have major limitations, including a reduced effectiveness in young children and a lack of cross-protection among different strains. Having studied host-pathogen interactions, microbiologists and immunologists argue in favor of topical gastrointestinal administration for improvement in vaccine efficacy. Here, recent advances in this field are summarized, including mechanisms of bacterial uptake at the intestinal epithelium, the assessment of protective host immunity, and improved animal models that closely mimic infection in humans. The pros and cons of existing vaccines are presented, along with recent progress made with novel formulations. Finally, new candidate antigens and their relevance in the refined design of anti-<jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>vaccines are discussed, along with antigen vectorization strategies such as nanoparticles or secretory immunoglobulins, with a focus on potentiating mucosal vaccine efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1128\/mmbr.00007-17","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:20:14Z","timestamp":1497486014000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["Vaccination against Salmonella Infection: the Mucosal Way"],"prefix":"10.1128","volume":"81","author":[{"given":"R\u00e9mi","family":"Gayet","sequence":"first","affiliation":[{"name":"Groupe Immunit\u00e9 des Muqueuses et Agents Pathog\u00e8nes, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Bioley","sequence":"additional","affiliation":[{"name":"R&amp;D Laboratory, Division of Immunology and Allergy, CHUV, Centre des Laboratoires d'Epalinges, Epalinges, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Rochereau","sequence":"additional","affiliation":[{"name":"Groupe Immunit\u00e9 des Muqueuses et Agents Pathog\u00e8nes, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Paul","sequence":"additional","affiliation":[{"name":"Groupe Immunit\u00e9 des Muqueuses et Agents Pathog\u00e8nes, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaise","family":"Corth\u00e9sy","sequence":"additional","affiliation":[{"name":"R&amp;D Laboratory, Division of Immunology and Allergy, CHUV, Centre des Laboratoires d'Epalinges, Epalinges, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"WHO Collaborating Centre for Reference and Research on Salmonella","author":"Patrick ADG","year":"2007","unstructured":"Patrick ADG Rimont F-XW . 2007. 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