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The asexual cycle can occur within any warm-blooded animal, but the sexual cycle is restricted to the feline intestinal epithelium.\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    is acquired through consumption of tissue cysts in undercooked meat as well as food and water contaminated with oocysts. Once ingested, it differentiates into a rapidly replicating asexual form and disseminates throughout the body during acute infection. After stimulation of the host immune response,\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    differentiates into a slow-growing, asexual cyst form that is the hallmark of chronic infection. One-third of the human population is chronically infected with\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    cysts, which can reactivate and are especially dangerous to individuals with reduced immune surveillance. Serious complications can also occur in healthy individuals if infected with certain\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    strains or if infection is acquired congenitally. No drugs are available to clear the cyst form during the chronic stages of infection. This therapeutic gap is due in part to an incomplete understanding of both host and pathogen responses during the progression of\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    infection. While many individual aspects of\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    infection are well understood, viewing the interconnections between host and parasite during acute and chronic infection may lead to better approaches for future treatment. The aim of this review is to provide an overview of what is known and unknown about the complex relationship between the host and parasite during the progression of\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    infection, with the ultimate goal of bridging these events.\n                  <\/jats:p>","DOI":"10.1128\/mmbr.00027-15","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T13:26:18Z","timestamp":1450877178000},"page":"387-401","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":120,"title":["Long-Term Relationships: the Complicated Interplay between the Host and the Developmental Stages of Toxoplasma gondii during Acute and Chronic Infections"],"prefix":"10.1128","volume":"79","author":[{"given":"Kelly J.","family":"Pittman","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Knoll","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"In Weiss LM, Kim K (ed), Toxoplasma gondii: the model apicomplexan","author":"Lindsay DS","year":"2014","unstructured":"Lindsay DS, Dubey JP. 2014. 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