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The rise of drug-resistant parasites has created an urgent need to study their biology in hopes of uncovering new potential drug targets. It has been established that disrupting gene expression by interfering with lysine acetylation is detrimental to survival of apicomplexan (\n              <jats:named-content content-type=\"genus-species\">Toxoplasma gondii<\/jats:named-content>\n              and\n              <jats:named-content content-type=\"genus-species\">Plasmodium<\/jats:named-content>\n              spp.) and kinetoplastid (\n              <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n              spp. and\n              <jats:named-content content-type=\"genus-species\">Trypanosoma<\/jats:named-content>\n              spp.) parasites. As \u201creaders\u201d of lysine acetylation, bromodomain proteins have emerged as key gene expression regulators and a promising new class of drug target. Here we review recent studies that demonstrate the essential roles played by bromodomain-containing proteins in parasite viability, invasion, and stage switching and present work showing the efficacy of bromodomain inhibitors as novel antiparasitic agents. In addition, we performed a phylogenetic analysis of bromodomain proteins in representative pathogens, some of which possess unique features that may be specific to parasite processes and useful in future drug development.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/mmbr.00047-16","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T02:00:57Z","timestamp":1484186457000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development"],"prefix":"10.1128","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-1088","authenticated-orcid":false,"given":"Victoria","family":"Jeffers","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, 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