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The ability to produce a clinical-grade vector at high yields remains a critical issue. One possible obstacle could be cellular factors known to inhibit human immunodeficiency virus (HIV). To date, five HIV restriction factors have been identified, although it is likely that more factors are involved in the complex HIV-cell interaction. Inhibitory factors that have an adverse effect but do not abolish virus production are much less well described. Therefore, a gap exists in the knowledge of inhibitory factors acting late in the HIV life cycle (from transcription to infection of a new cell), which are relevant to the lentiviral vector production process. The objective was to review the HIV literature to identify cellular factors previously implicated as inhibitors of the late stages of lentivirus production. A search for publications was conducted on MEDLINE via the PubMed interface, using the keyword sequence \u201cHIV restriction factor\u201d or \u201cHIV restriction\u201d or \u201cinhibit HIV\u201d or \u201crepress HIV\u201d or \u201crestrict HIV\u201d or \u201csuppress HIV\u201d or \u201cblock HIV,\u201d with a publication date up to 31 December 2016. Cited papers from the identified records were investigated, and additional database searches were performed. A total of 260 candidate inhibitory factors were identified. These factors have been identified in the literature as having a negative impact on HIV replication. This study identified hundreds of candidate inhibitory factors for which the impact of modulating their expression in lentiviral vector production could be beneficial.<\/jats:p>","DOI":"10.1128\/mmbr.00051-17","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T10:38:17Z","timestamp":1515407897000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature"],"prefix":"10.1128","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3454-5781","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"G\u00e9linas","sequence":"first","affiliation":[{"name":"Gene Medicine Research Group, NDCLS, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah 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