{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:48:11Z","timestamp":1793040491372,"version":"4.5.0"},"reference-count":275,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Fundaci\u00f3n S\u00e9neca","award":["21969\/PI\/22"],"award-info":[{"award-number":["21969\/PI\/22"]}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["PGC2018-097452-B-I00"],"award-info":[{"award-number":["PGC2018-097452-B-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["PID2021-124674NB-I00"],"award-info":[{"award-number":["PID2021-124674NB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Mol Biol Rev"],"published-print":{"date-parts":[[2024,3,27]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>The World Health Organization has established a fungal priority pathogens list that includes species critical or highly important to human health. Among them is the order Mucorales, a fungal group comprising at least 39 species responsible for the life-threatening infection known as mucormycosis. Despite the continuous rise in cases and the poor prognosis due to innate resistance to most antifungal drugs used in the clinic, Mucorales has received limited attention, partly because of the difficulties in performing genetic manipulations. The COVID-19 pandemic has further escalated cases, with some patients experiencing the COVID-19-associated mucormycosis, highlighting the urgent need to increase knowledge about these fungi. This review addresses significant challenges in treating the disease, including delayed and poor diagnosis, the lack of accurate global incidence estimation, and the limited treatment options. Furthermore, it focuses on the most recent discoveries regarding the mechanisms and genes involved in the development of the disease, antifungal resistance, and the host defense response. Substantial advancements have been made in identifying key fungal genes responsible for invasion and tissue damage, host receptors exploited by the fungus to invade tissues, and mechanisms of antifungal resistance. This knowledge is expected to pave the way for the development of new antifungals to combat mucormycosis. In addition, we anticipate significant progress in characterizing Mucorales biology, particularly the mechanisms involved in pathogenesis and antifungal resistance, with the possibilities offered by CRISPR-Cas9 technology for genetic manipulation of the previously intractable Mucorales species.<\/jats:p>","DOI":"10.1128\/mmbr.00188-22","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T08:19:41Z","timestamp":1709713181000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Molecular mechanisms that govern infection and antifungal resistance in Mucorales"],"prefix":"10.1128","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2059-303X","authenticated-orcid":false,"given":"Carlos","family":"Lax","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica y Microbiolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3762-5971","authenticated-orcid":false,"given":"Francisco E.","family":"Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica y Microbiolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3091-4378","authenticated-orcid":false,"given":"Eusebio","family":"Navarro","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica y Microbiolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-1726","authenticated-orcid":false,"given":"Victoriano","family":"Garre","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica y Microbiolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30312-3"},{"key":"e_1_3_2_3_2","unstructured":"WHO fungal priority pathogens list to guide research development and public health action. World Health Organization (WHO). Available from: https:\/\/www.who.int\/publications\/ i\/item\/9789240060241"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00861-x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/432579"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.556-569.2005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/599039"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.08.003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-023-00463-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2019.01.002"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073454"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-023-00464-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2023.101393"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040265"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.07.011"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5010026"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof9060659"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx017"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.11.021"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir880"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13123"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283165fd1"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03456.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01496.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/605445"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2020.05.008"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-316430"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2021.05.019"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2901.220926"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204781"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5030057"},{"key":"e_1_3_2_32_2","unstructured":"National Centre for Disease Control. 2021. CD alert: Covid-19 associated mucormycosis. Available from: https:\/\/ncdc.mohfw.gov.in\/WriteReadData\/l892s\/20590398661627904360.pdf"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07844-y"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13578"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.953750"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2022.01.016"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myz031"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00573-18"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049989"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000473"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir868"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.23"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00053-10"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab1066"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myaa036"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03976.x"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000560"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00746-18"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.12.006"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof8050457"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5040113"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.05.051"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01409-22"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5030056"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx162.124"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir866"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.2.236"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1177\/11206721211009450"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.083063"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir867"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0272-5231(02)00019-9"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.4081\/pr.2011.e18"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof8020194"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.110.6.845"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.01.005"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1220775"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.14740\/gr1662"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01390-14"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01112-0"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12550"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5040106"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01172-2"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1534\/g3.118.200235"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12228"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9030523"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000549"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01087-20"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12218"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evad046"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11071830"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.08.010"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01919-15"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04435-14"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.09.024"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17118-2"},{"key":"e_1_3_2_86_2","first-page":"221","volume-title":"Methods in molecular biology","author":"Nicol\u00e1s FE","year":"2018","unstructured":"Nicol\u00e1s FE, Navarro-Mendoza MI, P\u00e9rez-Arques C, L\u00f3pez-Garc\u00eda S, Navarro E, Torres-Mart\u00ednez S, Garre V. 2018. Molecular tools for carotenogenesis analysis in the mucoral Mucor circinelloides, p 221\u2013237. In Methods in molecular biology. Humana Press, New York, NY."},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c03307"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.4103\/cytojournal.cytojournal_35_17"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.2174\/978160805364311201010087"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5864175"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01230-21"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.14752"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1011900630987"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5020027"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1607787113"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3034-3042.2003"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.11.032"},{"key":"e_1_3_2_98_2","first-page":"29","article-title":"Experimental cerebral mucormycosis in rabbits with alloxan diabetes","volume":"28","author":"Bauer H","year":"1955","unstructured":"Bauer H, Flanagan JF, Sheldon WH. 1955. Experimental cerebral mucormycosis in rabbits with alloxan diabetes. Yale J Biol Med 28:29\u201336.","journal-title":"Yale J Biol Med"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3199-7_14"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof9030307"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3045"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.02.011"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2017.1360460"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00313-13"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362178185380421"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(73)90026-1"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.06.002"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.108.1.171"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.112.6.1069"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis767"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2021.100124"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.019992"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30754-6"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040908"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14515-0"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00434-19"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-017-0798-0"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141615"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-539-8_32"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709578105"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01414-20"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03386-22"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70686-7"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof4040118"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy042"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof4040128"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006150"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5010003"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71349"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00837-0"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05820-2"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02765-18"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01384-18"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42164"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.2.778-783.2005"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02949-19"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof7090738"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.26"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00140-18"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.12601"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.22.100168.000511"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00469"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00329"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.04.027"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.31.12.1109"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.89"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myaa104"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.38.3.1123-1129.1982"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111395"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.11.4489-4494.1995"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.51270.2"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.01.003"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.010"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02848-23"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3983214.x"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.48.2.458-463.1985"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02010-17"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.3.483"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1086\/428503"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12101"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.03.029"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012955"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00040-21"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2019-0246"},{"key":"e_1_3_2_165_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-021-00598-2"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002086"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13071"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011148"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003625"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226682"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07234.x"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26051-x"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004842"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008611"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13236"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052282"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9020459"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605917113"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2921"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14562"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.04.022"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.087445"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw1327"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23567"},{"key":"e_1_3_2_185_2","first-page":"76","article-title":"Attachment of spores of the human pathogenic fungus Rhizopus oryzae to extracellular matrix components","volume":"70","author":"Bouchara JP","year":"1996","unstructured":"Bouchara JP, Oumeziane NA, Lissitzky JC, Larcher G, Tronchin G, Chabasse D. 1996. Attachment of spores of the human pathogenic fungus Rhizopus oryzae to extracellular matrix components. Eur J Cell Biol 70:76\u201383.","journal-title":"Eur J Cell Biol"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbplus.2020.100037"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036952"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117676109"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.211"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.005991-0"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.863133"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-phyto-080508-081729"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-phyto-080417-045914"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003857117"},{"key":"e_1_3_2_195_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02052-8"},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.126"},{"key":"e_1_3_2_197_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03997"},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja062953o"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01784-06"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1086\/591461"},{"key":"e_1_3_2_201_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2007.01477.x"},{"key":"e_1_3_2_202_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.01.028"},{"key":"e_1_3_2_203_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.11.008"},{"key":"e_1_3_2_204_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2836"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82744"},{"key":"e_1_3_2_206_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.05.008"},{"key":"e_1_3_2_207_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2017.06.005"},{"key":"e_1_3_2_208_2","doi-asserted-by":"publisher","DOI":"10.1039\/c9mt00199a"},{"key":"e_1_3_2_209_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.13.7628"},{"key":"e_1_3_2_210_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004496"},{"key":"e_1_3_2_211_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1097(92)90579-d"},{"key":"e_1_3_2_212_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof6020089"},{"key":"e_1_3_2_213_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90314-x"},{"key":"e_1_3_2_214_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116419"},{"key":"e_1_3_2_215_2","doi-asserted-by":"publisher","DOI":"10.1128\/br.27.3.293-304.1963"},{"key":"e_1_3_2_216_2","volume-title":"Etudes sur la biere","author":"Pasteur L","year":"1876","unstructured":"Pasteur L. 1876. Etudes sur la biere"},{"key":"e_1_3_2_217_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.55.2.234-258.1991"},{"key":"e_1_3_2_218_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2002.tb00085.x"},{"key":"e_1_3_2_219_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.84.4.841-858.1962"},{"key":"e_1_3_2_220_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.84.4.829-840.1962"},{"key":"e_1_3_2_221_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(62)90314-1"},{"key":"e_1_3_2_222_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-82-1-15"},{"key":"e_1_3_2_223_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-82-1-1"},{"key":"e_1_3_2_224_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.116.2.972-980.1973"},{"key":"e_1_3_2_225_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.141.2.699-706.1980"},{"key":"e_1_3_2_226_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00444661"},{"key":"e_1_3_2_227_2","doi-asserted-by":"publisher","DOI":"10.1016\/0147-5975(87)90017-X"},{"key":"e_1_3_2_228_2","doi-asserted-by":"publisher","DOI":"10.1016\/0147-5975(87)90015-6"},{"key":"e_1_3_2_229_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.152.2.880-887.1982"},{"key":"e_1_3_2_230_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.152"},{"key":"e_1_3_2_231_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03396.x"},{"key":"e_1_3_2_232_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000828"},{"key":"e_1_3_2_233_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3485-3490.2000"},{"key":"e_1_3_2_234_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017046"},{"key":"e_1_3_2_235_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuv035"},{"key":"e_1_3_2_236_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00026-09"},{"key":"e_1_3_2_237_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2019.04.011"},{"key":"e_1_3_2_238_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00835-15"},{"key":"e_1_3_2_239_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2014.06.005"},{"key":"e_1_3_2_240_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05291.x"},{"key":"e_1_3_2_241_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00072-08"},{"key":"e_1_3_2_242_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084223"},{"key":"e_1_3_2_243_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2018.09.008"},{"key":"e_1_3_2_244_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof7040271"},{"key":"e_1_3_2_245_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199005020-00003"},{"key":"e_1_3_2_246_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104240"},{"key":"e_1_3_2_247_2","doi-asserted-by":"publisher","DOI":"10.2165\/11596540-000000000-00000"},{"key":"e_1_3_2_248_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(89)91792-0"},{"key":"e_1_3_2_249_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab1070"},{"key":"e_1_3_2_250_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02107-15"},{"key":"e_1_3_2_251_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02301-13"},{"key":"e_1_3_2_252_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12371"},{"key":"e_1_3_2_253_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06133-11"},{"key":"e_1_3_2_254_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02984.x"},{"key":"e_1_3_2_255_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00452-07"},{"key":"e_1_3_2_256_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1606-7"},{"key":"e_1_3_2_257_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.7.1488"},{"key":"e_1_3_2_258_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.2.241"},{"key":"e_1_3_2_259_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00905-16"},{"key":"e_1_3_2_260_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01382"},{"key":"e_1_3_2_261_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16123-9"},{"key":"e_1_3_2_262_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep26213"},{"key":"e_1_3_2_263_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06917-6"},{"key":"e_1_3_2_264_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00315-23"},{"key":"e_1_3_2_265_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf045"},{"key":"e_1_3_2_266_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00686-22"},{"key":"e_1_3_2_267_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt075"},{"key":"e_1_3_2_268_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2016-0050"},{"key":"e_1_3_2_269_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12611"},{"key":"e_1_3_2_270_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01751-17"},{"key":"e_1_3_2_271_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.660347"},{"key":"e_1_3_2_272_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13575"},{"key":"e_1_3_2_273_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006686"},{"key":"e_1_3_2_274_2","first-page":"164","volume-title":"Methods in enzymology","author":"Boeke JD","year":"1987","unstructured":"Boeke JD, Trueheart J, Natsoulis G, Fink GR. 1987. 5-fluoroorotic acid as a selective agent in yeast molecular genetics, p 164\u2013175. In Methods in enzymology"},{"key":"e_1_3_2_275_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007957"},{"key":"e_1_3_2_276_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02579-19"}],"container-title":["Microbiology and Molecular Biology Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mmbr.00188-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mmbr.00188-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T19:19:08Z","timestamp":1715800748000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mmbr.00188-22"}},"subtitle":[],"editor":[{"given":"Mark D.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,3,27]]},"references-count":275,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3,27]]}},"alternative-id":["10.1128\/mmbr.00188-22"],"URL":"https:\/\/doi.org\/10.1128\/mmbr.00188-22","relation":{},"ISSN":["1092-2172","1098-5557"],"issn-type":[{"value":"1092-2172","type":"print"},{"value":"1098-5557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,27]]},"assertion":[{"value":"2024-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00188-22"}}