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Beyond their roles in translation, deazaguanine modifications contribute to cellular stress resistance, self-nonself discrimination mechanisms, and host evasion defenses, directly modulating the adaptability of living organisms. Deazaguanine moieties extend beyond nucleic acid modifications, manifesting in the structural diversity of biologically active natural products. Their roles in fundamental cellular processes and their presence in biologically active natural products underscore their versatility and pivotal contributions to the intricate web of molecular interactions within living organisms. Here, we discuss the current understanding of the biosynthesis and multifaceted functions of deazaguanines, shedding light on their diverse and dynamic roles in the molecular landscape of life.<\/jats:p>","DOI":"10.1128\/mmbr.00199-23","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T15:00:22Z","timestamp":1709218822000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages"],"prefix":"10.1128","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-3785","authenticated-orcid":true,"given":"Val\u00e9rie","family":"de Cr\u00e9cy-Lagard","sequence":"first","affiliation":[{"name":"Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA"},{"name":"University of Florida Genetics Institute, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1269-6127","authenticated-orcid":false,"given":"Geoffrey","family":"Hutinet","sequence":"additional","affiliation":[{"name":"Department of Biology, Haverford College, Haverford, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6496-2071","authenticated-orcid":false,"given":"Jos\u00e9 D. 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