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Our recent clinical trial in human volunteers indicated that an RpoS\n            <jats:sup>+<\/jats:sup>\n            derivative of Ty2 was better at inducing immune responses than its RpoS\n            <jats:sup>\u2212<\/jats:sup>\n            counterpart. In this study, we demonstrate that a functional RpoS allele is beneficial for developing effective live attenuated vaccines against\n            <jats:italic>S<\/jats:italic>\n            . Typhi or in using\n            <jats:italic>S<\/jats:italic>\n            . Typhi as a recombinant attenuated vaccine vector to deliver other protective antigens.\n          <\/jats:p>","DOI":"10.1128\/msphere.00006-18","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T12:37:49Z","timestamp":1520858269000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Conversion of RpoS\n            <sup>\u2212<\/sup>\n            Attenuated Salmonella enterica Serovar Typhi Vaccine Strains to RpoS\n            <sup>+<\/sup>\n            Improves Their Resistance to Host Defense Barriers"],"prefix":"10.1128","volume":"3","author":[{"given":"Whittney N.","family":"Burda","sequence":"first","affiliation":[{"name":"Department of Infectious Disease and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen E.","family":"Brenneman","sequence":"additional","affiliation":[{"name":"The Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Gonzales","sequence":"additional","affiliation":[{"name":"The Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Roy","family":"Curtiss","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA"},{"name":"The Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"World health statistics 2014","author":"World Health Organization","year":"2013","unstructured":"World Health Organization. 2013. 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