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The principle virulence factor associated with clinical symptoms is a large protein toxin known as lethal toxin. The mechanism of lethal-toxin intoxication is assumed to be similar to that of the homologous toxins from\n            <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n            , but very few studies have been done in the context of endothelial cells, a relevant target in\n            <jats:italic>C. sordellii<\/jats:italic>\n            infections. This study was designed to test the role of the lethal-toxin enzymatic activities and membrane localization in endothelial cell toxicity and host substrate modification.\n          <\/jats:p>","DOI":"10.1128\/msphere.00012-15","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T17:49:53Z","timestamp":1447782593000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in Endothelial Cells"],"prefix":"10.1128","volume":"1","author":[{"given":"Ryan","family":"Craven","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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