{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:57:47Z","timestamp":1778032667857,"version":"3.51.4"},"reference-count":96,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI130128"],"award-info":[{"award-number":["1R01AI130128"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM008704"],"award-info":[{"award-number":["T32GM008704"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"MCTI | Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"HHS | NIH | National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["T32 AT008938"],"award-info":[{"award-number":["T32 AT008938"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","award":["Discovery Grant"],"award-info":[{"award-number":["Discovery Grant"]}],"id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008982","name":"MoSTR | National Science Foundation","doi-asserted-by":"publisher","award":["DEB-1442113"],"award-info":[{"award-number":["DEB-1442113"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,2,27]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n                    is the primary cause of aspergillosis, a devastating ensemble of diseases associated with severe morbidity and mortality worldwide.\n                    <jats:named-content content-type=\"genus-species\">A. fischeri<\/jats:named-content>\n                    is a close relative of\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    but is not generally observed to cause human disease. To gain insights into the underlying causes of this remarkable difference in pathogenicity, we compared two representative strains (one from each species) for a range of pathogenesis-relevant biological and chemical characteristics. We found that disease progression in multiple\n                    <jats:italic>A. fischeri<\/jats:italic>\n                    mouse models was slower and caused less mortality than\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    . Remarkably, the observed differences between\n                    <jats:italic>A. fischeri<\/jats:italic>\n                    and\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    strains examined here closely resembled those previously described for two commonly studied\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    strains, AF293 and CEA10.\n                    <jats:italic>A. fischeri<\/jats:italic>\n                    and\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    exhibited different growth profiles when placed in a range of stress-inducing conditions encountered during infection, such as low levels of oxygen and the presence of chemicals that induce the production of reactive oxygen species. We also found that the vast majority of\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    genes known to be involved in virulence are conserved in\n                    <jats:italic>A. fischeri<\/jats:italic>\n                    , whereas the two species differ significantly in their secondary metabolic pathways. These similarities and differences that we report here are the first step toward understanding the evolutionary origin of a major fungal pathogen.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00018-19","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T05:28:40Z","timestamp":1550554120000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Characterizing the Pathogenic, Genomic, and Chemical Traits of\n                    <i>Aspergillus fischeri<\/i>\n                    , a Close Relative of the Major Human Fungal Pathogen\n                    <i>Aspergillus fumigatus<\/i>"],"prefix":"10.1128","volume":"4","author":[{"given":"Matthew E.","family":"Mead","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja L.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huzefa A.","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah R.","family":"Beattie","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin H.","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8436-595X","authenticated-orcid":false,"given":"Jacob L.","family":"Steenwyk","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculdade de Ciencias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Chiaratto","sequence":"additional","affiliation":[{"name":"Faculdade de Ciencias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure N. A.","family":"Ries","sequence":"additional","affiliation":[{"name":"Faculdade de Ciencias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2986-350X","authenticated-orcid":false,"given":"Gustavo H.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Faculdade de Ciencias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas H.","family":"Oberlies","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-6551","authenticated-orcid":false,"given":"Antonis","family":"Rokas","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00683"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.06.017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.8.4731-4740.2004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00221-08"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002145"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000200"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0121-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0075-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1286"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0023"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00140-07"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.9.1574-1582.2005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01070-09"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00383-13"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2106.140717"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000046"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"Steenwyk JL Shen X-X Lind AL Goldman GG Rokas A. 2018. A robust phylogenomic timetree for biotechnologically and medically important fungi from Aspergillaceae (Eurotiomycetes. Ascomycota). bioRxiv doi:10.1101\/370429.","DOI":"10.1101\/370429"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4489\/MYCO.2010.38.1.001"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.agron.2015.02.003"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep39606"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.6.1580-1582.1992"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700715"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/60.6.861"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00151712"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02487-12"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01582-14"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu006"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw036"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006340"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01515-16"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005566"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00495-12"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-016-5510-4"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnv236"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018755"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2010.10.003"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715954115"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.07249-11"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2010.06.003"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx319"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005096"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2003583"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2005.05.046"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01485"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1313258110"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/np500497r"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2014.04.006"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.11.059"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11557-017-1282-4"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1039\/c7ra09602j"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2np00084a"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/1439-7633(20020703)3:7<619::AID-CBIC619>3.0.CO;2-9"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/2191-0855-3-71"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2017.21"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycres.2007.08.018"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2013.07.078"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)86791-X"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja509893s"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00963a024"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.28.245"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b07154"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac198254112219"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-005-0122-y"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201200523"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00828a054"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2012.701210"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.3.2.527-535.2004"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00077-10"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07263.x"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2013.12.010"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.2.310"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00055-08"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08283.x"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5493-5503.2005"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05726.x"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328348b159"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00536-15"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05178-11"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01556-09"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.3767\/persoonia.2018.41.08"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.120"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.1.6.12985"},{"key":"e_1_3_2_84_2","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council","year":"1996","unstructured":"National Research Council. 1996. Guide for the care and use of laboratory animals. National Academies Press, Washington, DC."},{"key":"e_1_3_2_85_2","volume-title":"The NCBI handbook","author":"Madden T","year":"2013","unstructured":"Madden T. 2013. The BLAST sequence analysis tool. In The NCBI handbook, 2nd ed. National Center for Biotechnology Information, Bethesda, MD. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK153387\/.","edition":"2"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101717"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.092759.109"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-2-r12"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr039"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1021\/np4004307"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2016.145"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601456103"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-539-8_7"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00340712"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.1.34-48.2003"},{"key":"e_1_3_2_96_2","volume-title":"Molecular cloning","author":"Sambrook J","year":"2001","unstructured":"Sambrook J, Russell DW. 2001. Molecular cloning, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.","edition":"3"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807606200"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00018-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00018-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T23:18:15Z","timestamp":1646695095000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00018-19"}},"subtitle":[],"editor":[{"given":"Aaron P.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2,27]]}},"alternative-id":["10.1128\/mSphere.00018-19"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00018-19","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/430728","asserted-by":"object"}]},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"assertion":[{"value":"2019-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00018-19"}}