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Patients are often treated with antifungal drugs such as amphotericin B (AmB) loaded into liposomes (AmB-LLs), but all antifungal drugs, including AmB-LLs, have serious limitations due to human toxicity and insufficient fungal cell killing. Even with the best current therapies, 1-year survival among patients with invasive aspergillosis is only 25 to 60%. Hence, there is a critical need for improved antifungal therapeutics. Dectin-1 is a mammalian protein that binds to beta-glucan polysaccharides found in nearly all fungal cell walls. We coated AmB-LLs with Dectin-1 to make DEC-AmB-LLs. DEC-AmB-LLs bound strongly to fungal cells, while AmB-LLs had little affinity. DEC-AmB-LLs killed or inhibited\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    10 times more efficiently than untargeted liposomes, decreasing the effective dose of AmB. Dectin-1-coated drug-loaded liposomes targeting fungal pathogens have the potential to greatly enhance antifungal therapeutics.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00025-19","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T06:30:10Z","timestamp":1549953010000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Dectin-1-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy"],"prefix":"10.1128","volume":"4","author":[{"given":"Suresh","family":"Ambati","sequence":"first","affiliation":[{"name":"Department of Genetics, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen R.","family":"Ferarro","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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