{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:34:17Z","timestamp":1785425657805,"version":"3.56.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2025,8,26]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Lei Chen works in the field of clinical diagnosis of antifungal tolerance and persistence. In this mSphere of Influence, he reflects on how the papers \u201cAntifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia\u201d by A. Rosenberg, I. V. Ene, M. Bibi, S. Zakin, et al. (Nat Commun 9:2470, 2018,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1038\/s41467-018-04926-x\" xlink:type=\"simple\">https:\/\/doi.org\/10.1038\/s41467-018-04926-x<\/jats:ext-link>\n                      ) and \u201cMacrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance\u201d by A. Arastehfar, F. Daneshnia, N. Cabrera, S. Penalva-Lopez, et al. (Nat Commun 14:1183, 2023,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1038\/s41467-023-36882-6\" xlink:type=\"simple\">https:\/\/doi.org\/10.1038\/s41467-023-36882-6<\/jats:ext-link>\n                      ) impacted his work on the development of diagnostic methods for antifungal tolerance and persistence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/msphere.00029-25","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:00:19Z","timestamp":1753707619000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["mSphere of Influence: Diagnosis of antifungal tolerance and persistence"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-9312","authenticated-orcid":false,"given":"Lei","family":"Chen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_3_2_4_2","unstructured":"World Health Organization. 2022. WHO fungal priority pathogens list to guide research development and public health action 2022. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240060241"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00511-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7999"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-030117-020345"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01112-22"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0322-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-016-0613-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04926-x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36882-6"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01172-24"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-023-01561-1"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.34"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.e02529-18"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41513-6"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay3041"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaj2191"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090817-062139"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2018.06.008"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13712"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51254"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.08.019"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00029-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00029-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T13:01:37Z","timestamp":1756213297000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msphere.00029-25"}},"subtitle":[],"editor":[{"given":"Bing","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,26]]}},"alternative-id":["10.1128\/msphere.00029-25"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00029-25","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"2025-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00029-25"}}