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This bacterium is able to cope with high levels of DNA lesions generated by exposure to extreme doses of ionizing radiation and to reconstruct a functional genome from hundreds of radiation-induced chromosomal fragments. Here, we identified partners of PprA, a radiation-induced\n            <jats:italic>Deinococcus<\/jats:italic>\n            -specific protein, previously shown to be required for radioresistance. Our study leads to three main findings: (i) PprA interacts with DNA gyrase after irradiation, (ii) treatment of cells with novobiocin results in defects in chromosome segregation that are aggravated by the absence of PprA, and (iii) PprA stimulates the decatenation activity of DNA gyrase. Our results extend the knowledge of how\n            <jats:named-content content-type=\"genus-species\">D. radiodurans<\/jats:named-content>\n            cells survive exposure to extreme doses of gamma irradiation and point out the link between DNA repair, chromosome segregation, and DNA gyrase activities in the radioresistant\n            <jats:named-content content-type=\"genus-species\">D. radiodurans<\/jats:named-content>\n            bacterium.\n          <\/jats:p>","DOI":"10.1128\/msphere.00036-15","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T15:07:46Z","timestamp":1452524866000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["PprA Protein Is Involved in Chromosome Segregation via Its Physical and Functional Interaction with DNA Gyrase in Irradiated Deinococcus radiodurans Bacteria"],"prefix":"10.1128","volume":"1","author":[{"given":"Alice","family":"Devigne","sequence":"first","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud, Universit\u00e9 Paris-Saclay, Gif-sur-Yvette cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"CEA, DSV, IBiTec-S, SPI, Li2D, Laboratory Innovative Technologies for Detection and Diagnostics, Bagnols-sur-C\u00e8ze, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Lisboa","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud, Universit\u00e9 Paris-Saclay, Gif-sur-Yvette cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Quevillon-Cheruel","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud, Universit\u00e9 Paris-Saclay, Gif-sur-Yvette cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Armengaud","sequence":"additional","affiliation":[{"name":"CEA, DSV, IBiTec-S, SPI, Li2D, Laboratory Innovative Technologies for Detection and Diagnostics, Bagnols-sur-C\u00e8ze, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Sommer","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud, Universit\u00e9 Paris-Saclay, Gif-sur-Yvette cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bouthier de la Tour","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud, Universit\u00e9 Paris-Saclay, Gif-sur-Yvette cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Servant","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud, Universit\u00e9 Paris-Saclay, Gif-sur-Yvette cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1264"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00015-10"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012765"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2011.10.024"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/261\/1\/012005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2015.05.010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05160"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Daly\nMJ\nMinton\nKW\n. 1995. 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Genome Res7:986\u2013995.","DOI":"10.1101\/gr.7.10.986"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.184.4.1003-1009.2002"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00036-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00036-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:51:28Z","timestamp":1646711488000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00036-15"}},"subtitle":[],"editor":[{"given":"Grant R.","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,25]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2,25]]}},"alternative-id":["10.1128\/mSphere.00036-15"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00036-15","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,25]]},"assertion":[{"value":"2015-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00036-15"}}