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As many pathogenic species of this genus can survive inside the host but also persist in environmental water, mostly forming biofilms, identifying the molecular basis of this capacity can impact the understanding of how leptospires are able to fulfill a complete life cycle that alternates between adaptation to the host and adaptation to hostile external environmental conditions. We identified several genes and regulatory networks that can be the kickoff for deepening understanding of the molecular mechanisms involving bacterial persistence via biofilm formation; understanding this is important for the future development of tools for controlling leptospirosis.\n          <\/jats:p>","DOI":"10.1128\/msphere.00042-16","type":"journal-article","created":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T05:26:49Z","timestamp":1460006809000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Transcriptome Sequencing Reveals Wide Expression Reprogramming of Basal and Unknown Genes in Leptospira biflexa Biofilms"],"prefix":"10.1128","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6516-3404","authenticated-orcid":false,"given":"Gregorio","family":"Iraola","sequence":"first","affiliation":[{"name":"Unidad de Bioinform\u00e1tica, Institut Pasteur, Montevideo, Montevideo, Uruguay"},{"name":"Secci\u00f3n Gen\u00e9tica Evolutiva, Facultad de Ciencias, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Spangenberg","sequence":"additional","affiliation":[{"name":"Unidad de Bioinform\u00e1tica, Institut Pasteur, Montevideo, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lopes Bastos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bacteriologia e Sa\u00fade, Instituto de Biologia, Universidade Federal da Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Gra\u00f1a","sequence":"additional","affiliation":[{"name":"Unidad de Bioinform\u00e1tica, Institut Pasteur, Montevideo, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bacteriologia e Sa\u00fade, Instituto de Biologia, Universidade Federal da Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1urea","family":"Almeida","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bacteriologia e Sa\u00fade, Instituto de Biologia, Universidade Federal da Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Greif","sequence":"additional","affiliation":[{"name":"Unidad de Biolog\u00eda Molecular, Institut Pasteur, Montevideo, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Robello","sequence":"additional","affiliation":[{"name":"Unidad de Biolog\u00eda Molecular, Institut Pasteur, Montevideo, Montevideo, Uruguay"},{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ristow","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bacteriologia e Sa\u00fade, Instituto de Biologia, Universidade Federal da Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Naya","sequence":"additional","affiliation":[{"name":"Unidad de Bioinform\u00e1tica, Institut Pasteur, Montevideo, Montevideo, Uruguay"},{"name":"Departamento de Producci\u00f3n Animal y Pasturas, Facultad de Agronom\u00eda, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.06.012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001607"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-45059-8_1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens3020280"},{"key":"e_1_3_2_6_2","volume-title":"Leptospira and leptospirosis","author":"Faine S","year":"1999","unstructured":"Faine S Adler B Bolin C Perolat P . 1999. 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