{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:06:03Z","timestamp":1793142363969,"version":"4.5.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,4,24]]},"abstract":"<jats:p>\n            The importance of this work relies on exploring the impact of multidrug-resistant bacterial infections such as those with carbapenem-resistant\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            (CRE) on sepsis mortality. These infections are growing at alarming rates worldwide and are now among the most frequent and difficult-to-treat bacteria due to the very few options for susceptible antimicrobials available. This study examined 1,190 sepsis episodes, and the main findings were as follows: (i) the prevalence of CRE infections significantly increased over time, (ii) CRE infection was associated with higher 30-day mortality than that of patients with other infections (63.8% versus 33.4%), and (iii) the effect of CRE on mortality was probably influenced by the fact that those patients received lower rates of empirical therapy with active antibiotics and were also diagnosed in more advanced stages of sepsis (septic shock). Those findings point to the need for rapid diagnostic methods to identify these bacteria and the need to adjust therapeutic guidelines to this worrisome epidemiological scenario.\n          <\/jats:p>","DOI":"10.1128\/msphere.00052-19","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T10:39:16Z","timestamp":1554806356000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["A Cohort Study of the Impact of Carbapenem-Resistant\n            <i>Enterobacteriaceae<\/i>\n            Infections on Mortality of Patients Presenting with Sepsis"],"prefix":"10.1128","volume":"4","author":[{"given":"Sabrina","family":"Sabino","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, Hospital S\u00e3o Lucas da PUCRS, Porto Alegre, Brazil"},{"name":"Medical Sciences Post-Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, 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